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Inhibition of actin polymerization by latrunculin A
Abstract
Latrunculin A, a toxin purified from the red sea sponge Latrunculia magnifica, was found previously to induce striking reversible changes in the morphology of mammalian cells in culture and to disrupt the organization of their microfilaments. We now provide evidence that latrunculin A affects the polymerization of pureactin in vitro in a manner consistent with the formation of a 1:1 molar complex between latrunculin A and G‐actin. The equilibrium dissociation constant (K d) for the reaction in vitro is about 0.2 μM whereas the effects of the drug on cultured cells are detectable at concentrations in the medium of 0.1–1 μM.
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Citations
Cites
Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured Cells
Spector, I., Shochet, N. R., Kashman, Y., & Groweiss, A. (1983) · Science · doi:10.1126/science.6681676 · Cited by 750
Self-citation
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Tanner, K. D. (2012) · CBE—Life Sciences Education · doi:10.1187/cbe.12-03-0033 · Cited by 618
Spector, I., Shochet, N. R., Blasberger, D., & Kashman, Y. (1989) · Cell Motility · doi:10.1002/cm.970130302 · Cited by 580
Self-citationLatrunculin alters the actin-monomer subunit interface to prevent polymerization
Morton, W. M., Ayscough, K. R., & McLaughlin, P. J. (2000) · Nature Cell Biology · doi:10.1038/35014075 · Cited by 523
The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines
Honkura, N., Matsuzaki, M., Noguchi, J., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.013 · Cited by 490
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Yarar, D., Waterman-Storer, C. M., & Schmid, S. L. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-09-0774 · Cited by 408
Metadata
- Authors
- Coué, M., Brenner, S. L., Spector, I., & Korn, E. D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1987-03-23
- Volume
- 213
- Issue
- 2
- Pages
- 316-318
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1984210761
- Cited by
- 822
- References
- 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Coué, M., Brenner, S. L., Spector, I., & Korn, E. D. (1987). Inhibition of actin polymerization by latrunculin A. FEBS Letters. https://doi.org/10.1016/0014-5793(87)81513-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
