Tissue‐specific expression of mRNAs encoding α‐ and β‐catalytic subunits of protein phosphatase 2A
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The mRNAs encoding the catalytic subunits of the type 1 phosphatase and the alpha and beta forms of phosphatase 2A (termed 2A alpha and 2A beta) were detected in all the porcine tissues examined (brain, heart, muscle, liver, kidney and ovaries). Total phosphatase 2A transcripts were about 10 times more abundant in brain and heart than in the other tissues while the distribution of phosphatase 1 mRNA showed significantly less variation. Phosphatase 2A alpha mRNA was about 10 times more abundant than phosphatase 2A beta mRNA in most tissues. Similarly, both the alpha and beta forms of the mRNA of the catalytic subunit of the phosphatase 2A were present in all the rat tissues examined. In addition to the 2 kb mRNA generally expressed, rat tissues also express a 2.8 kb mRNA related to 2A alpha and a 1.3 kb mRNA related to 2A beta.
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Cα (Ppp2ca) is expressed about 10-fold higher than Cβ (Ppp2cb) in most tissues, mainly due to the more active promoter region of Ppp2ca.
“In general, Cα (Ppp2ca) is expressed to a 10-fold higher extent than Cβ (Ppp2cb), mainly due to the more active promotor region of Ppp2ca in most tissues [33] (Fig. 2).”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [33]
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- Authors
- Khew-Goodall, Y., & Hemmings, B. A.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Hemmings, Brian A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1988-10-10
- Volume
- 238
- Issue
- 2
- Pages
- 265-268
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2022075010
- Cited by
- 102
- References
- 13
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- protein phosphatase 2A, tissue-specific gene expression, mRNA isoforms, porcine tissue, rat tissues, brain, heart
- MeSH terms
- Animals, Brain, DNA, Female, Gene Expression Regulation, Kidney, Liver, Muscles, Myocardium, Nucleic Acid Hybridization, Ovary, Phosphoprotein Phosphatases, RNA, Messenger, Swine, Tissue Distribution, Transcription, Genetic, Rats, Protein Phosphatase 1, Protein Phosphatase 2
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