Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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The ancient regulatory-protein family of WD-repeat proteins

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/bj3530417 · Cited by 1,392 · see citing works

Regulation of protein kinase cascades by protein phosphatase 2A

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Expansion of a novel CAG trinucleotide repeat in the 5′ region of PPP2R2B is associated with SCA12

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Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration.

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Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

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The B56 Family of Protein Phosphatase 2A (PP2A) Regulatory Subunits Encodes Differentiation-induced Phosphoproteins That Target PP2A to Both Nucleus and Cytoplasm

McCright, B., Rivers, A. M., Audlin, S., & Virshup, D. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22081 · Cited by 382 · see citing works

Tau domains, phosphorylation, and interactions with microtubules

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Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules

Sontag, E., Nunbhakdi‐Craig, V., Lee, G. S., Brandt, R., Kamibayashi, C., Kuret, J., White, C. L., Mumby, M. C., & Bloom, G. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25490 · Cited by 305 · see citing works

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

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Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin

Kins, S., Betz, H., & Kirsch, J. (2000) · Nature Neuroscience · doi:10.1038/71096 · Cited by 281 · see citing works

PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus

Vogelsberg-Ragaglia, V., Schuck, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7630 · Cited by 281 · see citing works

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

Silverstein, A. M., Barrow, C. A., Davis, A. J., & Mumby, M. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072071699 · Cited by 276 · see citing works

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

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Identification of a New Family of Protein Phosphatase 2A Regulatory Subunits

McCright, B., & Virshup, D. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26123 · Cited by 222 · see citing works

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

Götz, J., Probst, A., Ehler, E., Hemmings, B., & Kues, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12370 · Cited by 220 · see citing works

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase

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Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

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Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

Kins, S., Crameri, A., Evans, D. R. H., Hemmings, B. A., Nitsch, R. M., & Götz, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102621200 · Cited by 203 · see citing works

Inhibition of Protein Phosphatase 2A Overrides Tau Protein Kinase I/Glycogen Synthase Kinase 3β and Cyclin-dependent Kinase 5 Inhibition and Results in Tau Hyperphosphorylation in the Hippocampus of Starved Mouse

Planel, E., Yasutake, K., Fujita, S. C., & Ishiguro, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102780200 · Cited by 197 · see citing works

Brain protein phosphatase 2A: Developmental regulation and distinct cellular and subcellular localization by B subunits

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High Complexity in the Expression of the B′ Subunit of Protein Phosphatase 2A0

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Tau and transgenic animal models

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Diversity in the Regulatory B-Subunits of Protein Phosphatase 2A: Identification of a Novel Isoform Highly Expressed in Brain

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Brain protein serine/threonine phosphatases

Price, N. E., & Mumby, M. C. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80049-x · Cited by 109 · see citing works

Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments

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Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2

Mayer-Jaekel, R. E., Ohkura, H., Ferrigno, P. K., Andjelković, N., Shiomi, K., Uemura, T., Glover, D. M., & Hemmings, B. A. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.9.2609 · Cited by 107 · see citing works

Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discs.Preprint

Uemura, T., Shiomi, K., Togashi, S., et al. (1993) · Genes & Development · doi:10.1101/gad.7.3.429 · Cited by 106 · see citing works

Tissue‐specific expression of mRNAs encoding α‐ and β‐catalytic subunits of protein phosphatase 2A

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Dephosphorylation of microtubule‐associated protein tau by protein phosphatase‐1 and ‐2C and its implication in Alzheimer disease

Gong, C., Grundke, I., Damuni, Z., & Iqbal, K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80247-5 · Cited by 96 · see citing works

Interaction of Autophosphorylated Ca2+/Calmodulin-dependent Protein Kinase II with Neuronal Cytoskeletal Proteins

McNeill, R. B., & Colbran, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10043 · Cited by 89 · see citing works

Distinct role of protein phosphatase 2A subunit Cα in the regulation of E-cadherin and β-catenin during development

Götz, J., Probst, A., Mistl, C., Nitsch, R. M., & Ehler, E. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00267-7 · Cited by 88 · see citing works

Glial Cells Under Physiologic and Pathologic Conditions

Kurosinski, P., & Götz, J. (2002) · Archives of Neurology · doi:10.1001/archneur.59.10.1524 · Cited by 88 · see citing works

Diversity and phylogeny of gephyrin: Tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins

Ramming, M., Kins, S., Werner, N., Hermann, A., Betz, H., & Kirsch, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.10266 · Cited by 84 · see citing works

Neurofilament-associated protein phosphatase 2A: Its possible role in preserving neurofilaments in filamentous states

Saito, T., Shima, H., Osawa, Y., Nagao, M., Hemmings, B. A., Kishimoto, T., & Hisanaga, S.-I. (1995) · Biochemistry · doi:10.1021/bi00022a010 · Cited by 83 · see citing works

Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A

Strack, S., Chang, D., Zaucha, J. A., Colbran, R. J., & Wadzinski, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01377-0 · Cited by 83 · see citing works

Disruption of the cytoskeleton in Alzheimer's disease

Lee, V. M. ‐. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80073-5 · Cited by 75 · see citing works

Abnormal anaphase resolution (aar): a locus required for progression through mitosis in Drosophila

Gomes, R., Karess, R. E., Ohkura, H., et al. (1993) · Journal of Cell Science · doi:10.1242/jcs.104.2.583 · Cited by 45 · see citing works

An anchoring factor targets protein phosphatase 2A to brain microtubules

Price, N. E., Wadzinski, B. E., & Mumby, M. C. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00237-5 · Cited by 32 · see citing works

The Role of Protein Phosphatase 2A Catalytic Subunit Cα in Embryogenesis: Evidence from Sequence Analysis and Localization Studies

Götz, J., & Kues, W. A. (1999) · Biological Chemistry · doi:10.1515/bc.1999.139 · Cited by 16 · see citing works

Altered Expression Levels of the Protein Phosphatase 2A ABαC Enzyme Are Associated with Alzheimer Disease Pathology

Sontag, E., Luangpirom, A., Hladik, C., Mudrak, I., Ogris, E., Speciale, S., & White, C. L. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.4.287 · Cited by 228 · see citing works

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

Sents, W., Ivanova, E., Lambrecht, C., Haesen, D., & Janssens, V. (2013) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08579.x · Cited by 204 · see citing works

Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

Kins, S., Kurosinski, P., Nitsch, R. M., & Götz, J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63444-x · Cited by 155 · see citing works

The broken “Off” switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance

Ruvolo, P. P. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.08.002 · Cited by 143 · see citing works

Structure, Regulation, and Pharmacological Modulation of PP2A Phosphatases

Lambrecht, C., Haesen, D., Sents, W., Ivanova, E., & Janssens, V. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-562-0_17 · Cited by 140 · see citing works

Physiologic functions of PP2A: Lessons from genetically modified mice

Reynhout, S., & Janssens, V. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.07.010 · Cited by 124 · see citing works

Mice lacking phosphatase PP2A subunit PR61/B’δ ( <i>Ppp2r5d</i> ) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

Louis, J. V., Martens, E., Borghgraef, P., Lambrecht, C., Sents, W., Longin, S., Zwaenepoel, K., Pijnenborg, R., Landrieu, I., Lippens, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018777108 · Cited by 112 · see citing works

PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling

Hein, A. L., Seshacharyulu, P., Rachagani, S., Sheinin, Y. M., Ouellette, M. M., Ponnusamy, M. P., Mumby, M. C., Batra, S. K., & Yan, Y. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2119 · Cited by 66 · see citing works

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B′ regulatory subunits of protein phosphatase 2A in mice

Martens, E., Stevens, I., Janssens, V., Vermeesch, J., Götz, J., Goris, J., & Van Hoof, C. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.12.047 · Cited by 57 · see citing works

Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice

Schild, A., Ittner, L. M., & Götz, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.066 · Cited by 38 · see citing works

Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B″ subunits of protein phosphatase 2A

Zwaenepoel, K., Louis, J. V., Goris, J., & Janssens, V. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-393 · Cited by 30 · see citing works

Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice

Schild, A., Isenmann, S., Tanimoto, N., Tonagel, F., Seeliger, M. W., Ittner, L. M., Kretz, A., Ogris, E., & Götz, J. (2006) · Mechanisms of Development · doi:10.1016/j.mod.2006.03.003 · Cited by 17 · see citing works

Phosphatase Control by Methylation

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Generation of Active Protein Phosphatase 2A Is Coupled to Holoenzyme Assembly

Hombauer, H., Weismann, D., Mudrak, I., Stanzel, C., Fellner, T., Lackner, D. H., & Ogris, E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050155 · Cited by 88 · see citing works

Structural Basis of PP2A Inhibition by Small t Antigen

Cho, U., Morrone, S. R., Sablina, A. A., Arroyo, J. D., Hahn, W. C., & Xu, W. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050202 · Cited by 124 · see citing works

Overexpression of the PP2A-C5 gene confers increased salt tolerance in Arabidopsis thaliana

Hu, R., Zhu, Y., Shen, G., et al. (2017) · Plant Signaling & Behavior · doi:10.1080/15592324.2016.1276687 · Cited by 12 · see citing works

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

Xing, Y., Xu, Y., Chen, Y., Jeffrey, P. D., Chao, Y., Lin, Z., Li, Z., Strack, S., Stock, J. B., & Shi, Y. (2006) · Cell · doi:10.1016/j.cell.2006.09.025 · Cited by 334 · see citing works