The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation
Abstract
Several ion channels are reportedly redox responsive, but the molecular basis for the changes in activity is not known. The mechanism of nitric oxide action on the cardiac calcium release channel (ryanodine receptor) (CRC) in canines was explored. This tetrameric channel contains ∼84 free thiols and is S-nitrosylated in vivo. S-Nitrosylation of up to 12 sites (3 per CRC subunit) led to progressive channel activation that was reversed by denitrosylation. In contrast, oxidation of 20 to 24 thiols per CRC (5 or 6 per subunit) had no effect on channel function. Oxidation of additional thiols (or of another class of thiols) produced irreversible activation. The CRC thus appears to be regulated by poly-S-nitrosylation (multiple covalent attachments), whereas oxidation can lead to loss of control. These results reveal that ion channels can differentiate nitrosative from oxidative signals and indicate that the CRC is regulated by posttranslational chemical modification(s) of sulfurs.
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Cites
Nitric oxide synthases: Roles, tolls, and controls
Nathan, C., & Xie, Q.-W. (1994) · Cell · doi:10.1016/0092-8674(94)90266-6 · Cited by 2,918
Peroxynitrite oxidation of sulfhydryls.
Radi, R., Beckman, J. S., Bush, K. M., & Freeman, B. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,490
Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., & Stamler, J. S. (1993) · Nature · doi:10.1038/364626a0 · Cited by 2,433
Self-citationCalcium-induced release of calcium from the cardiac sarcoplasmic reticulum
Fabiato, A. (1983) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1983.245.1.c1 · Cited by 1,911
Redox signaling: Nitrosylation and related target interactions of nitric oxide
Stamler, J. S. (1994) · Cell · doi:10.1016/0092-8674(94)90269-0 · Cited by 1,723
Self-citationBlood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050
Self-citationNitric oxide in skeletal muscle
Kobzik, L., Reid, M. B., Bredt, D. S., & Stamler, J. S. (1994) · Nature · doi:10.1038/372546a0 · Cited by 965
Self-citationBrenman, J. E., Chao, D. S., Xia, H., Aldape, K., & Bredt, D. S. (1995) · Cell · doi:10.1016/0092-8674(95)90471-9 · Cited by 961
Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors
Meissner, G. (1994) · Annual Review of Physiology · doi:10.1146/annurev.ph.56.030194.002413 · Cited by 928
Self-citationMolecular and Cellular Aspects of Thiol–Disulfide Exchange
Gilbert, H. F. (1990) · Advances in Enzymology - and Related Areas of Molecular Biology · doi:10.1002/9780470123096.ch2 · Cited by 758
Cited by
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., & Sheu, S.-S. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2004 · Cited by 2,575
Protein S-nitrosylation: Purview and parameters
Hess, D. T., Matsumoto, A., Kim, S.-O., Marshall, H. E., & Stamler, J. S. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1569 · Cited by 2,153
Self-citationReactive Oxygen Species (Ros-Induced) Ros Release
Zorov, D. B., Filburn, C. R., Klotz, L.-O., Zweier, J. L., & Sollott, S. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1001 · Cited by 1,412
Physiology of Nitric Oxide in Skeletal Muscle
Stamler, J. S., & Meissner, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.209 · Cited by 1,080
Self-citationGuanylate cyclase and the ⋅NO/cGMP signaling pathway
Denninger, J. W., & Marletta, M. A. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00024-9 · Cited by 1,040
Metadata
- Authors
- Xu, L., Eu, J. P., Meissner, G., & Stamler, J. S.
- Venue
- Science
- Published
- 1998-01-09
- Volume
- 279
- Issue
- 5348
- Pages
- 234-237
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005591501
- Cited by
- 990
- References
- 36
- FWCI
- 23.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, L., Eu, J. P., Meissner, G., & Stamler, J. S. (1998). Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation. Science. https://doi.org/10.1126/science.279.5348.234
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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