The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
Induction of the peroxisome proliferator activated receptor by fenofibrate in rat liver
Open accessAbstract
The process of peroxisome proliferation in rodent liver by hypolipidemic compounds and related substances has recently been shown to be receptor‐madiated. In the present study, we have examined the effect of oral administration of the strong peroxisome proliferator fenofibrate on the hepatic expression level of the peroxisome proliferator activated receptor (PPAR) in rats. Immunoblots of rat liver cytosols and nuclear extracs using antibodies raised against recombinant PPAR/β‐galactosidase fusion proteins revealed a pronounced increase in the amount of PPAR protein in response to fenofibrate treatment. This induction could also be confirmed at the level or RNA by Northern blotting. A time‐course investigation showed a delayed accumulation of mRNA in response to the treatment, starting on day 2 after a latency period of at least one day. Thus, induction of the PPAR as a response to peroxisome proliferators represents one important dimension of the pleiotropic effects of peroxisome proliferators.
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“Although FF’s basic mechanism of action is known to involve PPAR-α agonist activity resulting in altered transcription of several genes, the actual genetic bases for variability in lipid response is poorly understood.”
From Fenofibrate and metabolic syndrome (2010) · cites this paper as [17]
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Metadata
- Authors
- Gebel, T., Arand, M., & Oesch, F.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Arand, Michael
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1992-08-31
- Volume
- 309
- Issue
- 1
- Pages
- 37-40
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2094123336
- Cited by
- 106
- References
- 19
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Keywords
- peroxisome proliferator-activated receptors, fenofibrate, peroxisome proliferation, lipid-lowering drugs, pleiotropy, rat liver
- MeSH terms
- Animals, Base Sequence, Cell Nucleus, Cytosol, Immune Sera, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Microbodies, Molecular Sequence Data, Oligodeoxyribonucleotides, Fenofibrate, Receptors, Cell Surface, Transcription Factors, Blotting, Northern, Polymerase Chain Reaction, Receptors, Cytoplasmic and Nuclear, Mice, Rats
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