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Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA
Abstract
Melanocytes and melanoma cells are known to possess receptors for melanocyte stimulating hormone (MSH). A cDNA clone, designated IID, has been isolated from human melanoma cells and encodes a MSH receptor. The cloned cDNA encodes a 317 amino acid protein with transmembrane topography characteristics of a G‐protein‐coupled receptor, but it does not show striking similarity to already published sequences of other G‐protein‐coupled receptors. When IID cDNA is expressed in COS‐7 cells, it binds an 125 I‐labelled MSH analogue (NDP‐MSH) in a specific manner. The bound ligand could be displaced by melanotropic peptides, α‐MSH, β‐MSH, γ‐MSH and ACTH (adrenocorticotropic hormone), but not by the non‐melanotropic peptide, β‐endorphine. This is the first report of the cloning of a receptor gene of the melanotropin receptor family.
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Cited by
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
Melanin pigmentation in mammalian skin and its hormonal regulation
Slominski, A., Tobin, D. J., Shibahara, S., & Wortsman, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00044.2003 · Cited by 2,015
Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776
Studies on the Physiological Functions of the Melanocortin System
Cone, R. D. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0034 · Cited by 615
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
Tao, Y.-X. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0037 · Cited by 531
Metadata
- Authors
- Chhajlani, V., & Wikberg, J. E. S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1992-09-14
- Volume
- 309
- Issue
- 3
- Pages
- 417-420
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2144969564
- Cited by
- 593
- References
- 0
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chhajlani, V., & Wikberg, J. E. S. (1992). Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Letters. https://doi.org/10.1016/0014-5793(92)80820-7
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