The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I
Open accessAbstract
We have analysed phosphorylation of the synthetic peptide AMARAASAAALARRR, and 23 variants, by mammalian, higher plant and yeast members of the SNF1 protein kinase subfamily (AMP‐activated protein kinase (AMPK), HMG‐CoA reductase kinase (HRK‐A), and SNF1 itself), and by mammalian calmodulin‐dependent protein kinase I (CaMKI). These four kinases recognize motifs which are very similar, although distinguishable. Our studies define the following recognition motifs: AMPK: Φ(X,β)XXS/TXXXΦ; HRK‐A: Φ(X,β)XXSXXXΦ; Snf1: ΦXRXXSXXXΦ; CaMKI: ΦXRXXS/TXXXΦ; where Φ is a hydrophobic residue (M, V, L, I or F) and β is a basic residue (R, K or H).
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
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Metadata
- Authors
- Dale, S., Wilson, W. A., Edelman, A. M., & Hardie, D. G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-03-20
- Volume
- 361
- Issue
- 2-3
- Pages
- 191-195
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2077821403
- Cited by
- 323
- References
- 25
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dale, S., Wilson, W. A., Edelman, A. M., & Hardie, D. G. (1995). Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I. FEBS Letters. https://doi.org/10.1016/0014-5793(95)00172-6
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