The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Formation of 8‐nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination
Abstract
Peroxynitrite is a strong oxidant formed by reaction of nitric oxide with superoxide in inflamed tissues. We have demonstrated that 8‐nitroguanine is formed dose‐dependently in calf thymus DNA incubated with low concentrations of peroxynitrite in vitro. 8‐Nitroguanine in acid‐hydrolyzed DNA was chemically reduced into 8‐aminoguanine, which was analyzed using high performance liquid chromatography with electrochemical detection. Only peroxynitrite, but not nitrite, tetranitromethane nor NO‐releasing compounds, formed 8‐nitroguanine. Antioxidants and desferrioxamine inhibited the reaction. 8‐Nitroguanine was depurinated from DNA incubated at pH 7.4, 37°C (). Peroxynitrite did not increase 8‐oxoguanine levels in DNA.
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Cites
The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511
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Halliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238
Oxidative Nucleobase Modifications Leading to Strand Scission
Burrows, C. J., & Muller, J. G. (1998) · Chemical Reviews · doi:10.1021/cr960421s · Cited by 1,736
Free radicals, oxidative stress, and antioxidants in human health and disease
Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
Metadata
- Authors
- Yermilov, V., Rubio, J., & Ohshima, H.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1995-12-04
- Volume
- 376
- Issue
- 3
- Pages
- 207-210
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1983400389
- Cited by
- 357
- References
- 1
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yermilov, V., Rubio, J., & Ohshima, H. (1995). Formation of 8‐nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination. FEBS Letters. https://doi.org/10.1016/0014-5793(95)01281-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
