Cited by 213Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and TreatmentsLiver physiology and pathology

Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis

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Nakanuma, Yasuni, Ohta, Goroku·1979·Gastroenterology

Abstract

Histometric examinations, based on the assumption that hepatic arterial branches and bile ducts run parallel within the portal tracts, suggest that in primary biliary cirrhosis bile ducts with a lumen (the smallest diameter between the subepithelial basal membranes) below 70--80 micron are destroyed. The smaller the ducts, the more they destroyed. Extensive destruction of the ducts was seen more frequently in the nonfibrotic stage of primary biliary cirrhosis than in later stages. Serial sections of the intrahepatic bile ducts in primary biliary cirrhosis revealed three types of periductal lesions preceding the disappearance of bile ducts: (A) periductal cellular reaction including features of chronic nonsuppurative destructive cholangitis, (B) periductal edema, and (C) periductal fibrosis. In the nonfibrotic stage, types A and C were frequent, whereas in the fibrotic stage types A and B were increased, and type C was predominant in the cirrhotic stage.

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Crossref · 10.1016/0016-5085(79)90396-2

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  • The characteristic histopathological lesion in primary biliary cholangitis, chronic non-suppurative destructive cholangitis, involves lymphocytic infiltration and destruction of the biliary epithelia of small-calibre to medium-calibre interlobular bile ducts, ultimately leading to bile duct destruction (ductopenia) and cholestasis.

    “The characteristic histopathological lesion in primary biliary cholangitis, chronic non-suppurative destructive cholangitis, involves lymphocytic infiltration and destruction of the biliary epithelia of small-calibre to medium-calibre interlobular bile ducts (figure 1), 6 ultimately leading to bile duct destruction (ductopenia) and cholestasis.”

    From Primary biliary cholangitis. (2024) · cites this paper as [6]

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Authors
Nakanuma, Y., & Ohta, G.
Affiliations
Kanazawa University (JP)
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1979-06
Volume
76
Issue
6
Pages
1326-1332
ISSN
0016-5085 (ISSN-L)
OpenAlex
W1503866127
Cited by
213
References
18
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 3
FWCI
3.28
Type
journal article
Language
en
Open access
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
primary biliary cirrhosis, intrahepatic bile ducts, bile duct destruction, periductal fibrosis, portal tract, histomorphometry, disease stage
MeSH terms
Adult, Aged, Arteries, Bile Ducts, Intrahepatic, Female, Humans, Hyperplasia, Japan, Liver, Liver Circulation, Liver Cirrhosis, Biliary, Male, Middle Aged

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