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Cited by 281

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum

Open access
Pothoulakis, Charalabos, Kelly, Ciaran P., Joshi, Manher A., Gao, Ning, O'Keane, Connor J., Castagliuolo, Ignazio, Lamont, J.Thomas·1993·Gastroenterology
DOI 10.1016/0016-5085(93)90280-p
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Abstract

BACKGROUND: Saccharomyces boulardii is a nonpathogenic yeast used for the prevention and treatment of Clostridium difficile-associated diarrhea and colitis. However, the mechanism by which S. boulardii exerts its protective effects remains unclear. METHODS: The binding of [3H]toxin A to its brush border receptor preincubated with S. boulardii-cultured suspension or filtered conditioned medium was measured in vitro. The effect of toxin A on secretion, epithelial permeability, and morphology in rat ileal loops in vivo was also examined in rats pretreated with S. boulardii. RESULTS: S. boulardii reduced [3H]toxin A-receptor binding in a dose-dependent fashion. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of ileal brush border exposed to S. boulardii-conditioned medium revealed a diminution of all brush border proteins. Treatment of rats with S. boulardii suspension reduced fluid secretion and mannitol permeability caused by toxin A. CONCLUSIONS: S. boulardii may reduce some of the enterotoxic effects of toxin A by inhibiting toxin A-receptor binding. This effect appears to be manifested by a secreted product of the yeast, possibly a protease.

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Metadata

Authors
Pothoulakis, C., Kelly, C. P., Joshi, M. A., Gao, N., O'Keane, C. J., Castagliuolo, I., & Lamont, J. T.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1993-04
Volume
104
Issue
4
Pages
1108-1115
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/0016-5085(93)90280-p
OpenAlex
W1502286186
Cited by
281
References
30
FWCI
6.79
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum. https://app.cochat.ai/papers/10.1016/0016-5085(93)90280-p
The paper
Pothoulakis, C., Kelly, C. P., Joshi, M. A., Gao, N., O'Keane, C. J., Castagliuolo, I., & Lamont, J. T. (1993). Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum. Gastroenterology. https://doi.org/10.1016/0016-5085(93)90280-p

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.