The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Clostridium difficile Infection
Abstract
Clostridium difficile infection is associated with broad-spectrum antibiotic therapy and is the most common cause of infectious diarrhea in hospital patients. Pathogenic strains of C. difficile produce two protein exotoxins, toxin A and toxin B, which cause colonic mucosal injury and inflammation. Infection may be asymptomatic, cause mild diarrhea, or result in severe pseudomembranous colitis. Diagnosis depends on the demonstration of C. difficile toxins in the stool. The first step in management is to discontinue the antibiotic that caused diarrhea. If diarrhea and colitis are severe or persistent, oral metronidazole is the treatment of choice. Oral vancomycin is also effective, but it is more expensive than metronidazole and its widespread use may encourage the proliferation of vancomycin-resistant nosocomial bacteria. Diarrhea and colitis usually improve within three days after a patient starts taking metronidazole or vancomycin, but 20% suffer a relapse of diarrhea when these agents are discontinued.
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Cites
Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia
Bartlett, J. G., Chang, T. W., Gurwith, M., Gorbach, S. L., & Onderdonk, A. B. (1978) · New England Journal of Medicine · doi:10.1056/nejm197803092981003 · Cited by 1,374
Nosocomial Acquisition of Clostridium difficile Infection
McFarland, L. V., Mulligan, M. E., Kwok, R. Y. Y., & Stamm, W. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901263200402 · Cited by 1,326
Kelly, C. P., Pothoulakis, C., & LaMont, J. T. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401273300406 · Cited by 1,321
Self-citationGlucosylation of Rho proteins by Clostridium difficile toxin B
Just, I., Selzer, J., Wilm, M., Eichel-Streiber, C. V., Mann, M., & Aktories, K. (1995) · Nature · doi:10.1038/375500a0 · Cited by 1,032
McFarland, L. V. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510480037031 · Cited by 857
Teasley, D., Olson, M., Gebhard, R., Gerding, D., Peterson, L., Schwartz, M., & Lee, J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91036-x · Cited by 785
HALL, I. C. (1935) · American Journal of Diseases of Children · doi:10.1001/archpedi.1935.01970020105010 · Cited by 772
CLOSTRIDIUM DIFFICILE AND THE ÆTIOLOGY OF PSEUDOMEMBRANOUS COLITIS
Larson, H. E., Price, A. B., Honour, P., & Borriello, S. P. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90912-1 · Cited by 652
Clindamycin-Associated Colitis: A Prospective Study
TEDESCO, F. J., BARTON, R. W., & ALPERS, D. H. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-4-429 · Cited by 606
Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: A prospective study
Surawicz, C. M., Elmer, G. W., Speelman, P., McFarland, L. V., Chinn, J., & Van Belle, G. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)91613-2 · Cited by 573
Cited by
Buffie, C. G., Jarchum, I., Equinda, M., Lipuma, L., Gobourne, A., Viale, A., Ubeda, C., Xavier, J., & Pamer, E. G. (2012) · Infection and Immunity · doi:10.1128/iai.05496-11 · Cited by 596
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614
Hickson, M., D'Souza, A. L., Muthu, N., Rogers, T. R., Want, S., Rajkumar, C., & Bulpitt, C. J. (2007) · BMJ · doi:10.1136/bmj.39231.599815.55 · Cited by 599
S-layers: principles and applications
Sleytr, U. B., Schuster, B., Egelseer, E.-M., & Pum, D. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12063 · Cited by 408
The physiology and collective recalcitrance of microbial biofilm communities
(2002) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(02)46005-5 · Cited by 370
Metadata
- Authors
- Kelly, C. P., & LaMont, J. T.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1998-02
- Volume
- 49
- Issue
- 1
- Pages
- 375-390
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2393115371
- Cited by
- 420
- References
- 56
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kelly, C. P., & LaMont, J. T. (1998). Clostridium difficile Infection. Annual Review of Medicine. https://doi.org/10.1146/annurev.med.49.1.375
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
