Cited by 119Gut microbiota and healthPeroxisome Proliferator-Activated ReceptorsGastrointestinal motility and disorders

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Kinetic studies on the metabolism of short-chain fatty acids and glucose by isolated rat colonocytes

Clausen, Mette Rye, Mortensen, Per Brøbech·1994·Gastroenterology

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Abstract

Background/aims Although the interest in colonic mucosal metabolism of short-chain fatty acids is steadily increasing, the kinetic parameters Vmax (maximum velocity) and Km (Michaelis constant) of the complete oxidation of these acids into CO2 by colonic epithelial cells have not previously been determined. Methods Isolated rat colonocytes were incubated in the presence of a concentration range of 14C-labeled acetate, propionate, butyrate, and glucose. Oxidation rates were obtained by quantifying the production of 14CO2. Vmax and Km were calculated by computer-fitting of the data to a Michaelis-Menten plot. Results The apparent Vmax values were similar comparing acetate, propionate, and butyrate (1.114 +/- 0.061, 0.991 +/- 0.072, and 1.007 +/- 0.070 mumol/min.g, respectively), but significantly lower for glucose (0.339 +/- 0.022 mumol/min.g). The corresponding Km values were all different and in the order of butyrate (0.184 +/- 0.017 mmol/L) Conclusions Colonic epithelial cells seem to utilize short-chain fatty acids in a preferential order of butyrate > propionate > acetate. Oxidation of propionate or acetate, however, may provide the energy needed for cellular functions if the metabolism of butyrate is impaired or the luminal supply is limited.

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Authors: Clausen, M. R., & Mortensen, P. B.
Affiliations: University of Copenhagen (DK)
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1994-02
Volume: 106
Issue: 2
Pages: 423-432
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/0016-5085(94)90601-7
OpenAlex: W1697601431
Cited by: 119
References: 41
Citations by year: 2026: 7 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 2
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: short-chain fatty acids, colonic epithelial cells, colonic mucosa, butyrate, propionate, acetate, glucose oxidation, Michaelis-Menten kinetics, substrate competition, non-competitive inhibition, mixed-type inhibition
MeSH terms: Adenosine Triphosphate, Animals, Carbon Dioxide, Coenzyme A, Colon, Fatty Acids, Volatile, Glucose, Ketone Bodies, Lactates, Male, Pectins, Triglycerides, Rats, Sprague-Dawley, Lactic Acid, Rats, In Vitro Techniques

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Kinetic studies on the metabolism of short-chain fatty acids and glucose by isolated rat colonocytes

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