High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

Inflammatory Bowel Disease

Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183 · see citing works

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne-Roussel, A., Thomas, G. D., Philpott, D. J., & Sansonetti, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200651200 · Cited by 2,397 · see citing works

Predictability of the postoperative course of Crohn's disease

Rutgeerts, P., Geboes, K., Vantrappen, G., Beyls, J., Kerremans, R., & Hiele, M. I. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90613-6 · Cited by 1,814 · see citing works

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K., Inamura, S., Kusumoto, S., Hashimoto, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200673200 · Cited by 1,694 · see citing works

Mucosal flora in inflammatory bowel disease

Swidsinski, A. V., Ladhoff, A., Pernthaler, A., Swidsinski, S., Loening-Baucke, V. A., Ortner, M., Weber, J., Hoffmann, U., Schreiber, S., Dietel, M., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.30294 · Cited by 1,344 · see citing works

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

Darfeuille–Michaud, A., Neut, C., Barnich, N., Lederman, E., Martino, P. D., Desreumaux, P., Gambiez, L. P., Joly, B., Cortot, A., & Colombel, J.-F. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70019-8 · Cited by 859 · see citing works

Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum

Rutgeerts, P., Peeters, M., Hiele, M. I., Vantrappen, G. R., Pennincx, F., Aerts, R., Kerremans, R., & Goboes, K. (1991) · The Lancet · doi:10.1016/0140-6736(91)90663-a · Cited by 758 · see citing works

Controlled trial of metronidazole treatment for prevention of crohn's recurrence after ileal resection

Rutgeerts, P., Hiele, M., Geboes, K., Peeters, M., Penninckx, F., Aerts, R., & Kerremans, R. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90121-3 · Cited by 743 · see citing works

Dysbiosis in inflammatory bowel disease

Tamboli, C. P., Neut, C., Desreumaux, P., & Colombel, J. F. (2004) · Gut · doi:10.1136/gut.53.1.1 · Cited by 743 · see citing works

Plasmid-controlled colonization factor associated with virulence in Esherichia coli enterotoxigenic for humans

Evans, D. G., Silver, R. P., Evans, D. J., Chase, D. G., & Gorbach, S. L. (1975) · Infection and Immunity · doi:10.1128/iai.12.3.656-667.1975 · Cited by 698 · see citing works

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

Hisamatsu, T., Suzuki, M., Reinecker, H., Nadeau, W. J., McCormick, B. A., & Podolsky, D. K. (2003) · Gastroenterology · doi:10.1053/gast.2003.50153 · Cited by 632 · see citing works

Epithelial cells as sensors for microbial infection.

Kagnoff, M. F., & Eckmann, L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119522 · Cited by 619 · see citing works

Crohn’s disease and the NOD2 gene: a role for paneth cells

Lala, S. G., Ogura, Y., Osborne, C., Hor, S. Y., Bromfield, A., Davies, S. E., Ogunbiyi, O. A., Núñez, G., & Keshav, S. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00661-9 · Cited by 528 · see citing works

Double blind, placebo controlled trial of metronidazole in Crohn's disease.

Sutherland, L. R., Singleton, J., Sessions, J. T., Hanauer, S., Krawitt, E. L., Rankin, G. B., Summers, R. J., Mekhjian, H. S., Greenberger, N. J., & Kelly, M. (1991) · Gut · doi:10.1136/gut.32.9.1071 · Cited by 527 · see citing works

Crohn's disease

Shanahan, F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07284-7 · Cited by 478 · see citing works

The Diarrheal Response of Humans to Some Classic Serotypes of Enteropathogenic Escherichia coli is Dependent on a Plasmid Encoding an Enteroadhesiveness Factor

Levine, M. M., Nataro, J. P., Karch, H., Baldini, M. M., Kaper, J. B., Black, R. E., Clements, M. L., & O’Brien, A. D. (1985) · The Journal of Infectious Diseases · doi:10.1093/infdis/152.3.550 · Cited by 472 · see citing works

Adherent Invasive Escherichia coli Strains from Patients with Crohn's Disease Survive and Replicate within Macrophages without Inducing Host Cell Death

Glasser, A.-L., Boudeau, J., Barnich, N., Perruchot, M.-H., Colombel, J., & Darfeuille–Michaud, A. (2001) · Infection and Immunity · doi:10.1128/iai.69.9.5529-5537.2001 · Cited by 465 · see citing works

Invasive Ability of an Escherichia coli Strain Isolated from the Ileal Mucosa of a Patient with Crohn’s Disease

Boudeau, J., Glasser, A.-L., Masseret, E., Joly, B., & Darfeuille–Michaud, A. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4499-4509.1999 · Cited by 449 · see citing works

Bacterial adhesins: function and structure

Klemm, P., & Schembri, M. A. (2000) · International Journal of Medical Microbiology · doi:10.1016/s1438-4221(00)80102-2 · Cited by 417 · see citing works

Entry of Shigella flexneri into HeLa cells: evidence for directed phagocytosis involving actin polymerization and myosin accumulation

Clerc, P., & Sansonetti, P. J. (1987) · Infection and Immunity · doi:10.1128/iai.55.11.2681-2688.1987 · Cited by 332 · see citing works

An antibiotic regimen for the treatment of active Crohn's disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin.

Prantera, C., Zannoni, F., Scribano, M. L., Berto, E., Andreoli, A., Kohn, A., & Luzi, C. (1996) · PubMed · Cited by 309 · see citing works

[Crohn's disease].

(2005) · PubMed · Cited by 298 · see citing works

Inducible and Constitutive β-Defensins Are Differentially Expressed in Crohn's Disease and Ulcerative Colitis

Wehkamp, J., Harder, J., Weichenthal, M., Mueller, O., Herrlinger, K. R., Fellermann, K., Schroeder, J. M., & Stange, E. F. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200307000-00001 · Cited by 295 · see citing works

Immunocytochemical evidence of Listeria, Escherichia coil, and Streptococcus antigens in Crohn's disease

Liu, Y., Kruiningen, H. J. V., West, A. B., Cartun, R. W., Cortot, A., & Colombel, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90687-8 · Cited by 290 · see citing works

Differential Induction of Colitis and Gastritis in HLA-B27 Transgenic Rats Selectively Colonized with Bacteroides vulgatus or Escherichia coli

Rath, H. C., Wilson, K. H., & Sartor, R. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.2969-2974.1999 · Cited by 276 · see citing works

Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease

Neut, C., Bulois, P., Desreumaux, P., Membré, J., Lederman, E., Gambiez, L. P., Cortot, A., Quandalle, P. A., Kruiningen, H. J. V., & Colombel, J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05613.x · Cited by 274 · see citing works

A Controlled Trial Comparing Ciprofloxacin With Mesalazine for The Treatment of Active Crohn's Disease

Colombel, J., Lémann, M., Cassagnou, M., Bouhnik, Y., Duclos, B., Dupas, J., Notteghem, B., & Mary, J. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.935_q.x · Cited by 253 · see citing works

Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA

Tieng, V., Bouguénec, C. L., du Merle, L., Bertheau, P., Desreumaux, P., Janin, A., Charron, D. J., & Toubert, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032668099 · Cited by 235 · see citing works

Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment

Dieleman, L. A., Goerres, M. S., Arends, A., Sprengers, D., Torrice, C., Hoentjen, F., Grenther, W. B., & Sartor, R. B. (2003) · Gut · doi:10.1136/gut.52.3.370 · Cited by 231 · see citing works

Long-term treatment of ulcerative colitis with ciprofloxacin: A prospective, double-blind, placebo-controlled study

Turunen, U., Färkkilä, M. A., HAKALA, K., Seppälä, K., Sivonen, K., OGREN, M., Vuoristo, M., Valtonen, V., & Miettinen, T. A. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70076-9 · Cited by 229 · see citing works

Granulomatous Infections: Etiology and Classification

Zumla, A. I., & James, D. G. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/23.1.146 · Cited by 219 · see citing works

Type 1 pili‐mediated adherence of Escherichia coli strain LF82 isolated from Crohn's disease is involved in bacterial invasion of intestinal epithelial cells

Boudeau, J., Barnich, N., & Darfeuille–Michaud, A. (2001) · Molecular Microbiology · doi:10.1111/j.1365-2958.2001.02315.x · Cited by 206 · see citing works

Clinical relevance of advances in genetics and pharmacogenetics of IBD

Ahmad, T., Tamboli, C., Jewell, D. P., & Colombel, J. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.061 · Cited by 180 · see citing works

Combination Ciprofloxacin and Metronidazole for Active Crohn’s Disease

Greenbloom, S., Steinhart, A. H., & Greenberg, G. R. (1998) · Canadian Journal of Gastroenterology · doi:10.1155/1998/349460 · Cited by 169 · see citing works

Adherent-invasive Escherichia coli: a putative new E. coli pathotype associated with Crohn's disease

Darfeuille–Michaud, A. (2002) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00201 · Cited by 158 · see citing works

Crohn's disease

Fellermann, K., Wehkamp, J., Herrlinger, K. R., & Stange, E. F. (2003) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200306000-00008 · Cited by 148 · see citing works

Pathogenesis of aphthoid ulcers in Crohn's disease: correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistry.

Fujimura, Y., Kamoi, R., & Iida, M. (1996) · Gut · doi:10.1136/gut.38.5.724 · Cited by 145 · see citing works

Unifying hypothesis for inflammatory bowel disease and associated colon cancer: sticking the pieces together with sugar

Rhodes, J. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91563-9 · Cited by 110 · see citing works

Virulence properties of Escherichia coli strains isolated from patients with inflammatory bowel disease.

Giaffer, M. H., Holdsworth, C. D., & Duerden, B. I. (1992) · Gut · doi:10.1136/gut.33.5.646 · Cited by 109 · see citing works

The “Early” Ulcerative Lesion of Crohnʼs Disease

Rickert, R. R., & Carter, H. W. (1980) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-198003000-00003 · Cited by 108 · see citing works

Characterization of plasmid-borne afa-3 gene clusters encoding afimbrial adhesins expressed by Escherichia coli strains associated with intestinal or urinary tract infections

Bouguénec, C. L., Garcia, M., Ouin, V., et al. (1993) · Infection and Immunity · doi:10.1128/iai.61.12.5106-5114.1993 · Cited by 96 · see citing works

Microbial factors in chronic intestinal inflammation

Sartor, R. B., Rath, H. C., & Sellon, R. K. (1996) · Current Opinion in Gastroenterology · doi:10.1097/00001574-199607000-00003 · Cited by 78 · see citing works

Increased incidence of faecal coliforms with in vitro adhesive and invasive properties in patients with ulcerative colitis.

Dickinson, R., Varian, S. A., Axon, A. T. R., et al. (1980) · Gut · doi:10.1136/gut.21.9.787 · Cited by 66 · see citing works

Probiotics in inflamatory bowel disease

Shanahan, F. (2001) · Gut · doi:10.1136/gut.48.5.609 · Cited by 60 · see citing works

Commensal bacteria as targets in Crohn's disease

Elson, C. O. (2000) · Gastroenterology · doi:10.1053/gast.2000.9159 · Cited by 59 · see citing works

A Molecular Strategy for the Study of Bacterial Invasion

Falkow, S., Small, P. L. C., Isberg, R. R., et al. (1987) · Clinical Infectious Diseases · doi:10.1093/clinids/9.supplement_5.s450 · Cited by 55 · see citing works

Comparative Value of Colonic Biopsy and Intraluminal Fluid Culture for Diagnosis of Bacterial Acute Colitis in Immunocompetent Patients

Barbut, F., Beaugerie, L., Delas, N., Fossati‐Marchal, S., Aygalenq, P., Petit, J., & the Infectious Colitis Study Group (1999) · Clinical Infectious Diseases · doi:10.1086/520215 · Cited by 39 · see citing works

Long-term treatment of ulcerative colitis with ciprofloxacin

Turunen, U., Färkkilä, M. A., & Valtonen, V. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70593-7 · Cited by 16 · see citing works

Crohn’s Disease

Kelvin, F. M., & Herlinger, H. (1999) · Springer eBooks · doi:10.1007/978-0-387-21565-5_15 · Cited by 16 · see citing works

Invasion of tissue culture cells by diarrhoeagenic strains of Escherichia coli which lack the enteroinvasive inv gene

Geyid, A., Fletcher, J. N., Gashe, B. A., & Ljungh, Å. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1996.tb00262.x · Cited by 14 · see citing works

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., Reyes, J. A., Shah, S. A., LeLeiko, N., Snapper, S. B., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-9-r79 · Cited by 2,713 · see citing works

Influence of diet on the gut microbiome and implications for human health

Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599 · see citing works

Inflammatory bowel disease: cause and immunobiology

Baumgart, D. C., & Carding, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60750-8 · Cited by 2,147 · see citing works

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works

Microbial Influences in Inflammatory Bowel Diseases

Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927 · see citing works

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works

Epidemiology and risk factors for IBD

Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741 · see citing works

Dysbiosis of the gut microbiota in disease

Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M., & Owen, L. J. (2015) · Microbial Ecology in Health & Disease · doi:10.3402/mehd.v26.26191 · Cited by 1,710 · see citing works

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699 · see citing works

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482 · see citing works

Low counts of Faecalibacterium prausnitzii in colitis microbiota

Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20903 · Cited by 1,275 · see citing works

Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

Kaplan, G. G., & Ng, S. C. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.020 · Cited by 1,224 · see citing works

The gut microbiota in IBD

Manichanh, C., Borruel, N., Casellas, F., & Guarner, F. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.152 · Cited by 1,160 · see citing works

A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes

Willing, B. P., Dicksved, J., Halfvarson, J., Andersson, A. F., Lucio, M., Zheng, Z., Järnerot, G., Tysk, C., Jansson, J. K., & Engstrand, L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.049 · Cited by 1,032 · see citing works

The genetics and immunopathogenesis of inflammatory bowel disease

Cho, J. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2340 · Cited by 940 · see citing works

Probiotics and the gut microbiota in intestinal health and disease

Gareau, M. G., Sherman, P. M., & Walker, W. A. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.117 · Cited by 907 · see citing works

IBD—what role do Proteobacteria play?

Mukhopadhya, I., Hansen, R., El-Omar, E. M., & Hold, G. L. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.14 · Cited by 810 · see citing works

Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches

Sartor, R. B., & Wu, G. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.012 · Cited by 808 · see citing works

The microbiome in infectious disease and inflammation

Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791 · see citing works

Intestinal microbiota in human health and disease: the impact of probiotics

Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724 · see citing works

The immune system and the gut microbiota: friends or foes?

Cerf-Bensussan, N., & Gaboriau-Routhiau, V. (2010) · Nature Reviews Immunology · doi:10.1038/nri2850 · Cited by 704 · see citing works

Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues

Lee, M., & Chang, E. B. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.09.056 · Cited by 645 · see citing works

The gut microbiota: a major player in the toxicity of environmental pollutants?

Claus, S. P., Guillou, H., & Ellero-Simatos, S. (2016) · npj Biofilms and Microbiomes · doi:10.1038/npjbiofilms.2016.3 · Cited by 678 · see citing works

Altered intestinal function in patients with chronic heart failure

Sandek, A., Bauditz, J., Swidsinski, A., Buhner, S., Weber-Eibel, J., von Haehling, S., Schroedl, W., Karhausen, T., Doehner, W., Rauchhaus, M., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.016 · Cited by 661 · see citing works

Effects of antibiotics on gut microbiota

Lange, K., Buerger, M., Stallmach, A., & Bruns, T. (2016) · Digestive Diseases · doi:10.1159/000443360 · Cited by 607 · see citing works

Review article: dietary fibre-microbiota interactions

Simpson, H. L., & Campbell, B. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13248 · Cited by 602 · see citing works

Differences in gut microbiota in patients with vs without inflammatory bowel diseases: A systematic review

Pittayanon, R., Lau, J. T., Leontiadis, G. I., Tse, F., Yuan, Y., Surette, M., & Moayyedi, P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.294 · Cited by 623 · see citing works

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Merad, M., Das, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.015 · Cited by 549 · see citing works

Western diet induces dysbiosis with increased <i>E coli</i> in CEABAC10 mice <i>,</i> alters host barrier function favouring AIEC colonisation

Martinez-Medina, M., Denizot, J., Dreux, N., Robin, F., Billard, E., Bonnet, R., Darfeuille-Michaud, A., & Barnich, N. (2014) · Gut · doi:10.1136/gutjnl-2012-304119 · Cited by 539 · see citing works

Gut inflammation can boost horizontal gene transfer between pathogenic and commensal <i>Enterobacteriaceae</i>

Stecher, B., Denzler, R., Maier, L., Bernet, F., Sanders, M. J., Pickard, D. J., Barthel, M., Westendorf, A. M., Krogfelt, K. A., Walker, A. W., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113246109 · Cited by 492 · see citing works

Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation

Iljazovic, A., Roy, U., Gálvez, E. J. C., Lesker, T. R., Zhao, B., Gronow, A., Amend, L., Will, S. E., Hofmann, J. D., Pils, M. C., et al. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-0296-4 · Cited by 454 · see citing works

Colonization of the Human Gut by <i>E. coli</i> and Colorectal Cancer Risk

Bonnet, M., Buc, E., Sauvanet, P., Darcha, C., Dubois, D., Pereira, B., Déchelotte, P., Bonnet, R., Pezet, D., & Darfeuille-Michaud, A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1343 · Cited by 475 · see citing works

Western diet induces a shift in microbiota composition enhancing susceptibility to adherent-invasive E. coli infection and intestinal inflammation

Agus, A., Denizot, J., Thévenot, J., Martinez-Medina, M., Massier, S., Sauvanet, P., Bernalier-Donadille, A., Denis, S., Hofman, P., Bonnet, R., et al. (2016) · Scientific Reports · doi:10.1038/srep19032 · Cited by 477 · see citing works

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

Schaubeck, M., Clavel, T., Calasan, J., Lagkouvardos, I., Haange, S. B., Jehmlich, N., Basic, M., Dupont, A., Hornef, M., Bergen, M. V., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309333 · Cited by 447 · see citing works

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy

de Souza, H. S. P., Fiocchi, C., & Iliopoulos, D. (2017) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2017.110 · Cited by 447 · see citing works

The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases

Chassaing, B., & Darfeuille–Michaud, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.054 · Cited by 443 · see citing works

Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa

Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414 · see citing works

Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease

Conte, M. P., Schippa, S., Zamboni, I., Penta, M., Chiarini, F., Seganti, L., Osborn, J., Falconieri, P., Borrelli, O., & Cucchiara, S. (2006) · Gut · doi:10.1136/gut.2005.078824 · Cited by 383 · see citing works

Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?

Hold, G. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i5.1192 · Cited by 365 · see citing works

Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease

Zhang, M., Sun, K., Wu, Y., Yang, Y., Tso, P., & Wu, Z. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00942 · Cited by 347 · see citing works

Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease

Collado, M. C., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.061366 · Cited by 354 · see citing works

Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice

Chassaing, B., Ley, R. E., & Gewirtz, A. T. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.033 · Cited by 326 · see citing works

Mining the microbiota for microbial and metabolite-based immunotherapies

Skelly, A. N., Sato, Y., Kearney, S., & Honda, K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0144-5 · Cited by 306 · see citing works

Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases

Packey, C. D., & Sartor, R. B. (2009) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32832a8a5d · Cited by 319 · see citing works

The commensal bacterium Faecalibacterium prausnitzii is protective in DNBS-induced chronic moderate and severe colitis models

Martín, R., Chain, F., Miquel, S., Lu, J., Gratadoux, J.-J., Sokol, H., Verdu, E. F., Bercik, P., Bermúdez-Humarán, L. G., & Langella, P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000440815.76627.64 · Cited by 284 · see citing works

Nutritional Basis for Colonization Resistance by Human Commensal Escherichia coli Strains HS and Nissle 1917 against E. coli O157:H7 in the Mouse Intestine

Maltby, R., Leatham-Jensen, M. P., Gibson, T., Cohen, P. S., & Conway, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053957 · Cited by 285 · see citing works

Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis

Werner, T., Wagner, S. J., Martínez, I., Walter, J., Chang, J.-S., Clavel, T., Kisling, S., Schuemann, K., & Haller, D. (2011) · Gut · doi:10.1136/gut.2010.216929 · Cited by 299 · see citing works

Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque

Yasuda, K., Oh, K., Ren, B., Tickle, T. L., Franzosa, E. A., Wachtman, L. M., Miller, A. D., Westmoreland, S. V., Mansfield, K. G., Vallender, E. J., et al. (2015) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2015.01.015 · Cited by 298 · see citing works

Biodiversity of the Mucosa-Associated Microbiota Is Stable Along the Distal Digestive Tract in Healthy Individuals and Patients With Ibd

Lepage, P., Seksik, P., Sutren, M., de la Cochetière, M.-F., Jian, R., Marteau, P., & Doré, J. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000159662.62651.06 · Cited by 270 · see citing works

Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified

Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258 · see citing works

Colonic mucosa-associated diffusely adherent <i>afaC+ Escherichia coli</i> expressing <i>lpfA</i> and <i>pks</i> are increased in inflammatory bowel disease and colon cancer

Prorok-Hamon, M., Friswell, M. K., Alswied, A., Roberts, C. L., Song, F., Flanagan, P. K., Knight, P., Codling, C., Marchesi, J. R., Winstanley, C., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-304739 · Cited by 236 · see citing works

The microbiota in inflammatory bowel disease: Current and therapeutic insights

Lane, E. R., Zisman, T., & Suskind, D. (2017) · Journal of Inflammation Research · doi:10.2147/jir.s116088 · Cited by 226 · see citing works

Race-dependent association of sulfidogenic bacteria with colorectal cancer

Yazici, C., Wolf, P. G., Kim, H., Cross, T.-W. L., Vermillion, K., Carroll, T., Augustus, G. J., Mutlu, E., Tussing-Humphreys, L., Braunschweig, C., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313321 · Cited by 215 · see citing works

Shift Towards Pro-inflammatory Intestinal Bacteria Aggravates Acute Murine Colitis via Toll-like Receptors 2 and 4

Heimesaat, M. M., Fischer, A., Siegmund, B., Kupz, A., Niebergall, J., Fuchs, D., Jahn, H.-K., Freudenberg, M., Loddenkemper, C., Batra, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000662 · Cited by 213 · see citing works

Intestinal Microbes in Inflammatory Bowel Diseases

Sartor, R. B., & Mazmanian, S. K. (2012) · The American Journal of Gastroenterology Supplements · doi:10.1038/ajgsup.2012.4 · Cited by 206 · see citing works

A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice

Caruso, R., Mathes, T., Martens, E. C., Kamada, N., Nusrat, A., Inohara, N., & Núñez, G. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw4341 · Cited by 185 · see citing works

Siderophore-mediated iron acquisition and modulation of host-bacterial interactions

Ellermann, M., & Arthur, J. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.489 · Cited by 186 · see citing works

Review article: probiotics and prebiotics in irritable bowel syndrome

SPILLER, R. (2008) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2008.03750.x · Cited by 190 · see citing works

Altered enteric microbiota ecology in interleukin 10-deficient mice during development and progression of intestinal inflammation

Maharshak, N., Packey, C. D., Ellermann, M., Manick, S., Siddle, J. P., Huh, E. Y., Plevy, S., Sartor, R. B., & Carroll, I. M. (2013) · Gut Microbes · doi:10.4161/gmic.25486 · Cited by 174 · see citing works

Lactoferrin in aseptic and septic inflammation

Lepanto, M. S., Rosa, L., Paesano, R., Valenti, P., & Cutone, A. (2019) · Molecules · doi:10.3390/molecules24071323 · Cited by 147 · see citing works

The Bacteriology of Pouchitis: A Molecular Phylogenetic Analysis Using 16S rRNA Gene Cloning and Sequencing

McLaughlin, S. D., Walker, A. W., Churcher, C., Clark, S. K., Tekkis, P. P., Johnson, M. W., Parkhill, J., Ciclitira, P. J., Dougan, G., Nicholls, R. J., et al. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181e3dc8b · Cited by 114 · see citing works

Healthy hosts rule within: ecological forces shaping the gut microbiota

Byndloss, M. X., Pernitzsch, S. R., & Bäumler, A. J. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0010-y · Cited by 109 · see citing works

A distinct gut microbiota composition in patients with ankylosing spondylitis is associated with increased levels of fecal calprotectin

Klingberg, E., Magnusson, M. K., Strid, H., Deminger, A., Ståhl, A., Sundin, J., Simrén, M., Carlsten, H., Öhman, L., & Forsblad-d’Elia, H. (2019) · Arthritis Research &amp; Therapy · doi:10.1186/s13075-019-2018-4 · Cited by 101 · see citing works

Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis

Imai, J., Kitamoto, S., Sugihara, K., Nagao-Kitamoto, H., Hayashi, A., Morhardt, T. L., Kuffa, P., Higgins, P. D. R., Barnich, N., & Kamada, N. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0138-4 · Cited by 91 · see citing works

Microbiota impact on the epigenetic regulation of colorectal cancer

Yang, T., Owen, J. L., Lightfoot, Y. L., Kladde, M. P., & Mohamadzadeh, M. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.08.005 · Cited by 90 · see citing works

Chronic intestinal inflammation induces stress-response genes in commensal Escherichia coli

Patwa, L. G., Fan, T., Tchaptchet, S., Liu, Y., Lussier, Y. A., Sartor, R. B., & Hansen, J. J. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.064 · Cited by 85 · see citing works

MicroRNA and Gut Microbiota: Tiny but Mighty—Novel Insights into Their Cross-talk in Inflammatory Bowel Disease Pathogenesis and Therapeutics

Casado-Bedmar, M., & Viennois, E. (2022) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjab223 · Cited by 77 · see citing works

Search for Localized Dysbiosis in Crohn's Disease Ulcerations by Temporal Temperature Gradient Gel Electrophoresis of 16S rRNA

Seksik, P., Lepage, P., de la Cochetière, M.-F., Bourreille, A., Sutren, M., Galmiche, J.-P., Doré, J., & Marteau, P. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.9.4654-4658.2005 · Cited by 77 · see citing works

Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response

Charlet, R., Pruvost, Y., Tumba, G., Istel, F., Poulain, D., Kuchler, K., Sendid, B., & Jawhara, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-21422-w · Cited by 74 · see citing works

<i>Lactobacillus gasseri</i>KS-13,<i>Bifidobacterium bifidum</i>G9-1, and<i>Bifidobacterium longum</i>MM-2 Ingestion Induces a Less Inflammatory Cytokine Profile and a Potentially Beneficial Shift in Gut Microbiota in Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Spaiser, S. J., Culpepper, T., Nieves, C., Ukhanova, M., Mai, V., Percival, S. S., Christman, M. C., & Langkamp-Henken, B. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2014.983249 · Cited by 66 · see citing works

Dietary Component-Induced Inflammation and Its Amelioration by Prebiotics, Probiotics, and Synbiotics

Bilal, M., Ashraf, S., & Zhao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931458 · Cited by 58 · see citing works

QseC inhibition as an antivirulence approach for colitis-associated bacteria

Rooks, M. G., Veiga, P., Reeves, A. Z., Lavoie, S., Yasuda, K., Asano, Y., Yoshihara, K., Michaud, M., Wardwell-Scott, L., Gallini, C. A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612836114 · Cited by 57 · see citing works

<i>Akkermansia muciniphila</i> strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice

Ring, C., Klopfleisch, R., Dahlke, K., Basic, M., Bleich, A., & Blaut, M. (2019) · Gut Microbes · doi:10.1080/19490976.2018.1511663 · Cited by 52 · see citing works

E. coli-mediated gut inflammation in genetically predisposed Crohn's disease patients

Barnich, N., Denizot, J., & Darfeuille-Michaud, A. (2013) · Pathologie Biologie · doi:10.1016/j.patbio.2010.01.004 · Cited by 34 · see citing works

Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation

Leifer, C. A., McConkey, C., Li, S., Chassaing, B., Gewirtz, A. T., & Ley, R. E. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.07.017 · Cited by 34 · see citing works

Discontinuous Variation in the Virulence of Bact. aertrycke Mutton

Wilson, G. S. (1928) · Journal of Hygiene · doi:10.1017/s0022172400009621 · Cited by 10 · see citing works

Mutator Natural Escherichia coli Isolates Have an Unusual Virulence Phenotype

Picard, B., Duriez, P., Gouriou, S., Matić, I., Denamur, É., & Taddéi, F. (2001) · Infection and Immunity · doi:10.1128/iai.69.1.9-14.2001 · Cited by 50 · see citing works

Virulence evolution

Schmid‐Hempel, P. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780198832140.003.0013 · Cited by 3 · see citing works

Exposure to pairs of Aeromonas strains enhances virulence in the Caenorhabditis elegans infection model

Mosser, T., Talagrand-Reboul, É., Colston, S. M., Graf, J., Figueras, M. J., Jumas‐Bilak, E., & Lamy, B. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01218 · Cited by 42 · see citing works

A Proteomics View of Virulence Factors of Staphylococcus aureus

Engelmann, S., & Hecker, M. (2009) · Genome dynamics · doi:10.1159/000235771 · Cited by 8 · see citing works