Cited by 349Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

Endometriosis and Infertility: Epidemiology and Evidence‐based Treatments

Ozkan, Sebiha, Murk, William, Arici, Aydin·2008·Annals of the New York Academy of Sciences

Abstract

Endometriosis is an estrogen‐dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5–5% in fertile and 25–40% in infertile women. The optimal choice of management for endometriosis‐associated infertility remains obscure. Removal or suppression of endometrial deposits by medical or surgical means constitutes the basis of endometriosis management. Current evidence indicates that suppressive medical treatment of endometriosis does not benefit fertility and should not be used for this indication alone. Surgery is probably efficacious for all stages of the disease. Controlled ovarian hyperstimulation with intrauterine insemination is recommended in early‐stage and surgically corrected endometriosis when pelvic anatomy is normal. In advanced cases, in vitro fertilization is a treatment of choice, and its success may be augmented with prolonged gonadotropin‐releasing hormone analog treatment. Further randomized clinical trials focusing on diverse etiopathogenic mechanisms and therapeutic innovation are necessary to find more conclusive, evidence‐based answers regarding this enigmatic disease.

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Registry

Crossref · 10.1196/annals.1434.007

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99 of 99 references verified0 citation errors · 0 not checkable

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Authors
Ozkan, S., Murk, W., & Arici, A.
Affiliations
Yale University (US)
Corresponding author
Arici, Aydin
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2008-04
Volume
1127
Issue
1
Pages
92-100
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2109367793
Cited by
347
References
100
Citations by year
2026: 9 · 2025: 22 · 2024: 25 · 2023: 15 · 2022: 27 · 2021: 12 · 2020: 30 · 2019: 33 · 2018: 14 · 2017: 17 · 2016: 24 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 22
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, infertility, endometriosis-associated infertility, endometriosis surgery, controlled ovarian stimulation, intrauterine insemination, in vitro fertilization, GnRH analogues, estrogen dependence, pelvic anatomy
MeSH terms
Endometriosis, Female, Fertilization in Vitro, Humans, Infertility, Infertility, Female, Male, Ovulation Induction, Pregnancy, Prevalence, Treatment Outcome, Evidence-Based Medicine, Reproductive Techniques, Assisted

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