Endometriosis and Infertility: Epidemiology and Evidence‐based Treatments
Abstract
Endometriosis is an estrogen‐dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5–5% in fertile and 25–40% in infertile women. The optimal choice of management for endometriosis‐associated infertility remains obscure. Removal or suppression of endometrial deposits by medical or surgical means constitutes the basis of endometriosis management. Current evidence indicates that suppressive medical treatment of endometriosis does not benefit fertility and should not be used for this indication alone. Surgery is probably efficacious for all stages of the disease. Controlled ovarian hyperstimulation with intrauterine insemination is recommended in early‐stage and surgically corrected endometriosis when pelvic anatomy is normal. In advanced cases, in vitro fertilization is a treatment of choice, and its success may be augmented with prolonged gonadotropin‐releasing hormone analog treatment. Further randomized clinical trials focusing on diverse etiopathogenic mechanisms and therapeutic innovation are necessary to find more conclusive, evidence‐based answers regarding this enigmatic disease.
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Up to 80% of women with dysmenorrhea and up to 40% of infertile women have endometriosis.
“It is estimated that up to 80% of women with dysmenorrhea and up to 40% of infertile women have endometriosis (2,3).”
From Patients’ report on how endometriosis affects health, work, and daily life (2010) · cites this paper as [3]
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- Authors
- Ozkan, S., Murk, W., & Arici, A.
- Affiliations
- Yale University (US)
- Corresponding author
- Arici, Aydin
- ORCID
- Arici, Aydin
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2008-04
- Volume
- 1127
- Issue
- 1
- Pages
- 92-100
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W2109367793
- Cited by
- 347
- References
- 100
- Citations by year
- 2026: 9 · 2025: 22 · 2024: 25 · 2023: 15 · 2022: 27 · 2021: 12 · 2020: 30 · 2019: 33 · 2018: 14 · 2017: 17 · 2016: 24 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 22
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, infertility, endometriosis-associated infertility, endometriosis surgery, controlled ovarian stimulation, intrauterine insemination, in vitro fertilization, GnRH analogues, estrogen dependence, pelvic anatomy
- MeSH terms
- Endometriosis, Female, Fertilization in Vitro, Humans, Infertility, Infertility, Female, Male, Ovulation Induction, Pregnancy, Prevalence, Treatment Outcome, Evidence-Based Medicine, Reproductive Techniques, Assisted
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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