Cited by 681Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

Endometriosis and Infertility

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Macer, Matthew Latham, Taylor, Hugh S.·2012·Obstetrics and Gynecology Clinics of North America

Abstract

Endometriois has been associated with infertility; however, the mechanisms by which it affects fertility are still not fully understood. This article reviews the proposed mechanisms of endometriosis pathogenesis, its effects on fertility, and treatments of endometriosis-associated infertility. Theories on the cause of the disease include retrograde menstruation, coelomic metaplasia, altered immunity, stem cells, and genetics. Endometriosis affects gametes and embryos, the fallopian tubes and embryo transport, and the eutopic endometrium; these abnormalities likely all impact fertility. Current treatment options of endometriosis-associated infertility include surgery, superovulation with intrauterine insemination, and in vitro fertilization. We also discuss potential future treatments for endometriosis-related infertility.

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Authors
Macer, M. L., & Taylor, H. S.
Affiliations
Yale University (US)
Corresponding author
Taylor, Hugh S.
Venue
Obstetrics and Gynecology Clinics of North America
Publisher
Elsevier BV
Published
2012-12
Volume
39
Issue
4
Pages
535-549
ISSN
0889-8545 (ISSN-L)
OpenAlex
W1788063486
Cited by
681
References
89
Citations by year
2026: 44 · 2025: 84 · 2024: 92 · 2023: 65 · 2022: 83 · 2021: 65 · 2020: 58 · 2019: 48 · 2018: 29 · 2017: 28 · 2016: 27 · 2015: 22 · 2014: 26 · 2013: 9
FWCI
2.48
Type
journal article
Language
en
Open access
Locations
  • Obstetrics and Gynecology Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668, R01HD076422, R01HD036887)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, endometriosis-associated infertility, endometriosis pathogenesis, retrograde menstruation, stem cells, gametes, embryo transport, oviduct, eutopic endometrium, superovulation, intrauterine insemination, in vitro fertilization, surgical treatment
MeSH terms
Endometriosis, Female, Fertilization in Vitro, Humans, Infertility, Female, Insemination, Artificial, Pregnancy, Superovulation, Pelvic Pain, Reproductive Techniques, Assisted, Precision Medicine

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