Endometriosis and Infertility
Open accessAbstract
Endometriois has been associated with infertility; however, the mechanisms by which it affects fertility are still not fully understood. This article reviews the proposed mechanisms of endometriosis pathogenesis, its effects on fertility, and treatments of endometriosis-associated infertility. Theories on the cause of the disease include retrograde menstruation, coelomic metaplasia, altered immunity, stem cells, and genetics. Endometriosis affects gametes and embryos, the fallopian tubes and embryo transport, and the eutopic endometrium; these abnormalities likely all impact fertility. Current treatment options of endometriosis-associated infertility include surgery, superovulation with intrauterine insemination, and in vitro fertilization. We also discuss potential future treatments for endometriosis-related infertility.
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Women with EM are more likely to seek reproductive assistance.
“Women with EM are more likely to seek reproductive assistance [6].”
From Women with Endometriosis—Who Is at Risk for Complications Associated with Pregnancy and Childbirth? A Retrospective Case–Control Study (2024) · cites this paper as [6]
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Veth, V. B., van de Kar, M. M., Duffy, J. M., van Wely, M., Mijatovic, V., & Maas, J. W. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014788.pub2 · Cited by 39 · see citing works
BCL-6 Overexpression as a predictor for endometriosis in patients undergoing in vitro fertilization
Nezhat, C., Rambhatla, A., Miranda-Silva, C., Asiaii, A., Nguyen, K., Eyvazzadeh, A., Tazuke, S., Agarwal, S., Jun, S., Nezhat, A., et al. (2020) · JSLS : Journal of the Society of Laparoscopic & Robotic Surgeons · doi:10.4293/jsls.2020.00064 · Cited by 34 · see citing works
Pagano, F., Schwander, A., Vaineau, C., Knabben, L., Nirgianakis, K., Imboden, S., & Mueller, M. D. (2023) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2023.01.006 · Cited by 31 · see citing works
Naem, A., Andrikos, A., Constantin, A., Khamou, M., Andrikos, D., Laganà, A., De Wilde, R., & Krentel, H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206455 · Cited by 28 · see citing works
Naem, A., Krentel, H., Moawad, G., Naem, J., Venezia, R., Etrusco, A., Terzic, S., & Laganà, A. S. (2024) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2024.102500 · Cited by 15 · see citing works
The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis
Grigoriadis, G., Roman, H., Gkrozou, F., & Daniilidis, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13164817 · Cited by 10 · see citing works
The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis
Grigoriadis, G., & Daniilidis, A. (2024) · doi:10.20944/preprints202407.0446.v1 · Cited by 10 · see citing works
Gruber, T. M., Ortlieb, L., Henrich, W., & Mechsner, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020414 · Cited by 9 · see citing works
“Women with EM are more likely to seek reproductive assistance [6].”
Background
- Authors
- Macer, M. L., & Taylor, H. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Taylor, Hugh S.
- ORCID
- Taylor, Hugh S.
- Venue
- Obstetrics and Gynecology Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 39
- Issue
- 4
- Pages
- 535-549
- ISSN
- 0889-8545 (ISSN-L)
- PMC
- PMC3538128
- OpenAlex
- W1788063486
- Cited by
- 681
- References
- 89
- Citations by year
- 2026: 44 · 2025: 84 · 2024: 92 · 2023: 65 · 2022: 83 · 2021: 65 · 2020: 58 · 2019: 48 · 2018: 29 · 2017: 28 · 2016: 27 · 2015: 22 · 2014: 26 · 2013: 9
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Obstetrics and Gynecology Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668, R01HD076422, R01HD036887)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, endometriosis-associated infertility, endometriosis pathogenesis, retrograde menstruation, stem cells, gametes, embryo transport, oviduct, eutopic endometrium, superovulation, intrauterine insemination, in vitro fertilization, surgical treatment
- MeSH terms
- Endometriosis, Female, Fertilization in Vitro, Humans, Infertility, Female, Insemination, Artificial, Pregnancy, Superovulation, Pelvic Pain, Reproductive Techniques, Assisted, Precision Medicine
About these checks
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