The DOI matches its Crossref record.
Down's syndrome and atherosclerosis
Abstract
Necropsy findings in patients with Down's syndrome have suggested an absence of atherosclerosis throughout the cardiovascular system, but there are also contradictory results. We compared the left coronary arteries of 15 institutionalised Down's syndrome patients (5 males, 10 females, mean age 51 years) with those of 6 other institutionalised mentally retarded patients (4 males, 2 females, mean age 49) and 20 normal, free-living subjects (10 males, 10 females, mean age 48) by macroscopic inspection of the opened coronary arteries and by biochemical analysis of their intima-media. The arteries of Down patients contained a lower percentage of raised lesions and less calcium than the arteries of the control groups. Thus, even though the coronary arteries of mongoloids were not completely free of atherosclerosis, it was milder than in other mental patients and free-living subjects of the same age.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The serum cholesterol and lipid profiles of individuals with trisomy 21 are abnormal, yet they are protected against atherosclerosis.
“Interestingly, the serum cholesterol and lipid profiles of these individuals are abnormal, yet they are protected against atherosclerosis [55], [56].”
From LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease (2010) · cites this paper as [56]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 11
- Murdoch, 1977, Down's syndrome: an atheroma-free model?, Br. Med. J., 2, 226, 10.1136/bmj.2.6081.226 · DOI · Paper page
- Scoggin, 1982, Down's syndrome as a model disease, Arch. Intern. Med., 142, 462, 10.1001/archinte.142.3.462 · DOI
- Moss, 1980, Pre-atherosclerotic lesions in Down syndrome, J. Ment. Defic. Res., 24, 137
- Salo, 1979, Plasma lipids and lipoproteins in Down's syndrome, Scand. J. Clin. Invest., 39, 485, 10.3109/00365517909106135 · DOI
- Dörner, 1984, Cholesterol fractions and triglycerides in children and adults with Down's syndrome, Clin. Chim. Acta, 142, 307, 10.1016/0009-8981(84)90267-5 · DOI
- Ylä-Herttuala, 1986, Glycosarninoglycans in normal and atherosclerotic human coronary arteries, Lab. Invest., 54, 402
- Ylä-Herttuala, 1987, Atherosclerosis and biochemical composition of coronary arteries in Finnish men, Atherosclerosis, 65, 109, 10.1016/0021-9150(87)90012-8 · DOI
- Folch, 1957, A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem., 226, 497, 10.1016/S0021-9258(18)64849-5 · DOI · Paper page
- Steinberg, 1988, Metabolism of lipoproteins and their role in the pathogenesis of atherosclerosis, Vol. 18, 1
- Anneren, 1987, Lipid peroxidation and superoxide dismutase-1 and glutathione peroxidase activities in trisomy 16 fetal mice and human trisomy 21 fibroblasts, Pediatr. Res., 21, 88, 10.1203/00006450-198701000-00019 · DOI
- Sinet, 1979, Trisomy 21 (Down's syndrome). Glutathione peroxidase, hexose monophosphate shunt and I.Q., Life Sci., 24, 29, 10.1016/0024-3205(79)90276-5 · DOI
Cited by
Sorted by citations
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L. J., Fisher, E. M. C., & Strydom, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3983 · Cited by 562
Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology
Head, E., T. Lott, I., M. Wilcock, D., & A. Lemere, C. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666151020114607 · Cited by 289
Alzheimer disease and Down syndrome: factors in pathogenesis
Lott, I. T., & Head, E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.08.005 · Cited by 212
Cerebrovascular pathology in Down syndrome and Alzheimer disease
Head, E., Phelan, M. J., Doran, E., Kim, R. C., Poon, W. W., Schmitt, F. A., & Lott, I. T. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0499-4 · Cited by 105
Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome
Wilcock, D. M., Schmitt, F. A., & Head, E. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.007 · Cited by 56
Abisambra, J. F., Fiorelli, T., Padmanabhan, J., Neame, P., Wefes, I., & Potter, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008556 · Cited by 42
Metadata
- Authors
- Ylä-Herttuala, S., Luoma, J., Nikkari, T., & Kivimäki, T.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 1989-04
- Volume
- 76
- Issue
- 2-3
- Pages
- 269-272
- ISSN
- 0021-9150
- Cited by
- 85
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
