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Cited by 78

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Catabolism of lipoprotein(a) in familial hypercholesterolaemic subjects

Knight, Brian L., Perombelon, Y.F.Nicholas, Soutar, Anne K., Wade, David P., Seed, Mary·1991·Atherosclerosis
DOI 10.1016/0021-9150(91)90025-x
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Abstract

The in vivo turnover of autologous lipoprotein(a) (Lp(a)) was studied in four heterozygous familial hypercholesterolaemic (FH) subjects and four subjects who were hyperlipidaemic but not FH. Each of the FH subjects exhibited a much lower fractional catabolic rate (FCR) for LDL than each of the non-FH subjects. Lp(a) was purified by sequential density gradient centrifugations and was radio-iodinated. The labelled Lp(a) ran as a single band on electrophoresis in gradient polyacrylamide gels. Less than 5% of the label was in lipid, with about 40% of the remainder on apolipoprotein B (apo B) and 60% on apo(a). Labelled and unlabelled Lp(a) competed equally poorly with LDL for binding to LDL receptors on cultured fibroblasts. The FCR of Lp(a), calculated from the decay of the specific radioactivity of the Lp(a) isolated from the daily blood samples, was the same in FH subjects as in non-FH subjects. There was no consistent relationship between Lp(a) FCR and the plasma Lp(a) concentration or between FCR and the Lp(a) phenotype, at least within this sample of subjects. There was a strong association between Lp(a) concentration and production rate, with values for non-FH and FH subjects falling on the same line. The rate of decline of radioactivity in whole plasma was consistently slower than the fall in specific radioactivity of the isolated Lp(a). This difference was more marked in FH subjects than in non-FH subjects and resulted from the accumulation of radioactivity derived from…

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Crossref · 10.1016/0021-9150(91)90025-x

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Citations

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Research works printed but not linked: 16

  1. Koschinsky, 1990, Apolipoprotein(a) size heterogeneity is related to variable number of repeat sequences in its mRNA, Biochemistry, 29, 640, 10.1021/bi00455a007 · DOI
  2. Utermann, 1987, Lp(a) glycoprotein phenotypes, J. Clin. Invest., 80, 458, 10.1172/JCI113093 · DOI
  3. Krempler, 1980, Turnover of lipoprotein(a) in man, J. Clin. Invest., 65, 1483, 10.1172/JCI109813 · DOI
  4. Krempler, 1983, Studies on the role of specific cell surface receptors in the removal of lipoprotein (a) in man, J. Clin. Invest., 71, 1431, 10.1172/JCI110896 · DOI · Paper page
  5. Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
  6. Bilheimer, 1975, Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolaemia, J. Clin. Invest., 56, 1420, 10.1172/JCI108223 · DOI
  7. Laemmli, 1970, Cleavage of structural protein during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 · DOI · Paper page
  8. Kraft, 1988, Lp(a) phenotyping by immunoblotting with polyclonal and monoclonal antibodies, Arteriosclerosis, 8, 212, 10.1161/01.ATV.8.3.212 · DOI
  9. Soutar, 1986, Immunoprecipitation of the low-density-lipoprotein (LDL) receptor and its precursor from human monocyte-derived macrophages, Biochem. J., 233, 683, 10.1042/bj2330683 · DOI
  10. Knight, 1989, Defective processing and binding of low-density lipoprotein receptors in fibroblasts from a familial hypercholesterolaemic subject, Eur. J. Biochem., 179, 693, 10.1111/j.1432-1033.1989.tb14602.x · DOI
  11. Matthews, 1957, The theory of tracer experiments with 131I-labelled plasma proteins, Phys. Med. Biol., 2, 36, 10.1088/0031-9155/2/1/305 · DOI
  12. Armstrong, 1990, Heterogeneity of human lipoprotein Lp (a): cytochemical and biochemical studies on the interaction of two Lp(a) species with the LDL receptor, J. Lipid Res, 31, 429, 10.1016/S0022-2275(20)43165-7 · DOI
  13. Armstrong, 1985, Isolation, characterization, and uptake in human fibroblasts of an apo(a)-free lipoprotein obtained on reduction of lipoprotein(a), J. Lipid Res., 26, 1314, 10.1016/S0022-2275(20)34257-7 · DOI
  14. Hofmann, 1990, Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice, J. Clin. Invest., 85, 1542, 10.1172/JCI114602 · DOI · Paper page
  15. Thiery, 1988, Serum lipoprotein Lp(a) concentrations are not influenced by an HMG CoA reductase inhibitor, Klin. Wochenschr., 66, 462, 10.1007/BF01745519 · DOI
  16. Neven, 1990, Rhesus monkey model of familial hypercholesterolemia: relation between plasma Lp(a) levels, apo(a) isoforms, and LDL-receptor function, J. Lipid Res., 31, 633, 10.1016/S0022-2275(20)42831-7 · DOI

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Metadata

Authors
Knight, B. L., Perombelon, Y. F. N., Soutar, A. K., Wade, D. P., & Seed, M.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
1991-04
Volume
87
Issue
2-3
Pages
227-237
ISSN
0021-9150
DOI
10.1016/0021-9150(91)90025-x
Cited by
78
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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