Colestipol hydrochloride in hypercholesterolemic patients—Effect on serum cholesterol and mortality
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In the 8 trials of established nonstatin therapies that ultimately act predominantly via upregulation of LDL receptor expression, each 1-mmol/L reduction in LDL-C was associated with an RR of 0.75 (95% CI, 0.66-0.86; P = .002) for major vascular events.
“Specifically, each 1-mmol/L reduction in LDL-C was associated with an RR of 0.75 (95% CI, 0.66-0.86;P = .002)in major vascular events”
From Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis (2016) · cites this paper as [50]
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Silverman, M. G., Ference, B. A., Im, K., Wiviott, S. D., Giugliano, R. P., Grundy, S. M., Braunwald, E., & Sabatine, M. S. (2016) · JAMA · doi:10.1001/jama.2016.13985 · Cited by 1,483 · see citing works
Buchwald, H., Varco, R. L., Matts, J. P., Long, J. M., Fitch, L. L., Campbell, G. S., Pearce, M. B., Yellin, A. E., Edmiston, W. A., Smink, R. D., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010043231404 · Cited by 1,001 · see citing works
Muldoon, M. F., Manuck, S. B., & Matthews, K. A. (1990) · BMJ · doi:10.1136/bmj.301.6747.309 · Cited by 960 · see citing works
Cholesterol Reduction Yields Clinical Benefit: Impact of Statin Trials
Gould, A. L., Rossouw, J. E., Santanello, N. C., Heyse, J. F., & Furberg, C. D. (1998) · Circulation · doi:10.1161/01.cir.97.10.946 · Cited by 442 · see citing works
Cholesterol lowering trials in coronary heart disease: Frequency of citation and outcome.
Ravnskov, U. (1992) · BMJ · doi:10.1136/bmj.305.6844.15 · Cited by 313 · see citing works
Davidson, M. H., Dillon, M. A., Gordon, B., Jones, P., Samuels, J., Weiss, S., Isaacsohn, J., Toth, P., & Burke, S. K. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.16.1893 · Cited by 307 · see citing works
Cholesterol Reduction Yields Clinical Benefit: A New Look at Old Data
Gould, A. L., Rossouw, J. E., Santanello, N. C., Heyse, J. F., & Furberg, C. D. (1995) · Circulation · doi:10.1161/01.cir.91.8.2274 · Cited by 272 · see citing works
Drug Treatment of Hyperlipidemia in Women
Walsh, J. M. E. (2004) · JAMA · doi:10.1001/jama.291.18.2243 · Cited by 270 · see citing works
Efficacy of colesevelam on lowering glycemia and lipids
Aggarwal, S., Loomba, R. S., & Arora, R. R. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31823a109f · Cited by 30 · see citing works
- Authors
- Dorr, A. E., Gundersen, K., Schneider, J. C., Spencer, T. W., & Martin, W. B.
- Venue
- Journal of Chronic Diseases
- Publisher
- Elsevier BV
- Published
- 1978-01
- Volume
- 31
- Issue
- 1
- Pages
- 5-14
- ISSN
- 0021-9681 (ISSN-L)
- OpenAlex
- W1993181745
- Cited by
- 203
- References
- 0
- Citations by year
- 2026: 1 · 2023: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chronic Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- hypercholesterolemia, serum cholesterol lowering, coronary heart disease mortality, all-cause mortality, bile acid sequestrants, drug safety, sex differences in mortality
- MeSH terms
- Cholesterol, Clinical Trials as Topic, Colestipol, Coronary Disease, Female, Humans, Hypercholesterolemia, Male, Middle Aged, Placebos, Polyamines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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