Cited by 30Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

Efficacy of colesevelam on lowering glycemia and lipids

Aggarwal, Saurabh, Loomba, Rohit S., Arora, Rohit R.·2012·Journal of Cardiovascular Pharmacology

Abstract

A few trials have investigated the efficacy of colesevelam in the reduction of glycemic and lipid outcomes. These meta-analysis pooled data from 8 such trials and found that colesevelam is associated with significant reductions in plasma fasting glucose, hemoglobin A1c, and low-density lipoprotein. Insignificant reductions in high-density lipoprotein and total cholesterol were also noted along with significant increase in triglycerides. This analysis concludes that colesevelam may be of particular benefit in managing type 2 diabetic patients with hyperlipidemia in whom low-density lipoprotein levels are of particular concern. Caution should be taken in patients who have hypertriglyceridemia or low high-density lipoprotein levels before starting therapy.

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Crossref · 10.1097/fjc.0b013e31823a109f

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35 of 35 references verified0 citation errors · 0 not checkable

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Authors
Aggarwal, S., Loomba, R. S., & Arora, R. R.
Affiliations
  • Rosalind Franklin University of Medicine and Science (US)
  • Children's Hospital of Wisconsin (US)
  • Captain James A. Lovell Federal Health Care Center (US)
Corresponding author
Aggarwal, Saurabh
Venue
Journal of Cardiovascular Pharmacology
Published
2012-02
Volume
59
Issue
2
Pages
198-205
ISSN
0160-2446 (ISSN-L)
OpenAlex
W2009738913
Cited by
30
References
35
Citations by year
2025: 2 · 2023: 2 · 2022: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 1
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiovascular Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
colesevelam, glycemic control, lipid lowering, type 2 diabetes, hyperlipidemia, LDL cholesterol, HbA1c, fasting blood glucose, triglycerides, HDL cholesterol, bile acid sequestrants
MeSH terms
Colesevelam Hydrochloride, Allylamine, Animals, Anticholesteremic Agents, Blood Glucose, Cholesterol, Diabetes Mellitus, Type 2, Glycated Hemoglobin, Humans, Hypercholesterolemia, Cholesterol, LDL, Triglycerides

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