Efficacy of colesevelam on lowering glycemia and lipids
Abstract
A few trials have investigated the efficacy of colesevelam in the reduction of glycemic and lipid outcomes. These meta-analysis pooled data from 8 such trials and found that colesevelam is associated with significant reductions in plasma fasting glucose, hemoglobin A1c, and low-density lipoprotein. Insignificant reductions in high-density lipoprotein and total cholesterol were also noted along with significant increase in triglycerides. This analysis concludes that colesevelam may be of particular benefit in managing type 2 diabetic patients with hyperlipidemia in whom low-density lipoprotein levels are of particular concern. Caution should be taken in patients who have hypertriglyceridemia or low high-density lipoprotein levels before starting therapy.
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There is no evidence for benefit of bile acid sequestrant (BAS) in addition to statins in patients with clinical ASCVD.
“but there is no evidence for benefit of BAS in addition to statins in this population (21).”
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- Authors
- Aggarwal, S., Loomba, R. S., & Arora, R. R.
- Affiliations
- Rosalind Franklin University of Medicine and Science (US)
- Children's Hospital of Wisconsin (US)
- Captain James A. Lovell Federal Health Care Center (US)
- Corresponding author
- Aggarwal, Saurabh
- Venue
- Journal of Cardiovascular Pharmacology
- Published
- 2012-02
- Volume
- 59
- Issue
- 2
- Pages
- 198-205
- ISSN
- 0160-2446 (ISSN-L)
- OpenAlex
- W2009738913
- Cited by
- 30
- References
- 35
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- colesevelam, glycemic control, lipid lowering, type 2 diabetes, hyperlipidemia, LDL cholesterol, HbA1c, fasting blood glucose, triglycerides, HDL cholesterol, bile acid sequestrants
- MeSH terms
- Colesevelam Hydrochloride, Allylamine, Animals, Anticholesteremic Agents, Blood Glucose, Cholesterol, Diabetes Mellitus, Type 2, Glycated Hemoglobin, Humans, Hypercholesterolemia, Cholesterol, LDL, Triglycerides
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