The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Studies in prebiotic synthesis
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It has long been known for the purines, but not the pyrimidines, that simply heating the nucleobase with ribose or ribose-phosphate results in the synthesis of the corresponding ribonucleoside or ribonucleotide, but in low yield (Fuller et al. 1972).”
From Protocells and RNA Self-Replication (2018) · cites this paper as Fuller et al. 1972
Citations
Cites
Mechanism of ε15 conversion studied with bacteriophage mutants
Bray, D., & Robbins, P. W. (1967) · Journal of Molecular Biology · doi:10.1016/s0022-2836(67)80037-8 · Cited by 280
Cyanoacetylene in Prebiotic Synthesis
Sanchez, R. A., Ferris, J. P., & Orgel, L. E. (1966) · Science · doi:10.1126/science.154.3750.784 · Cited by 270
Self-citationPrebiotic Synthesis of Polypeptides by Heterogeneous Polycondensation of Amino-acid Adenylates
Paecht‐Horowitz, M., BERGER, J., & Katchalsky, A. (1970) · Nature · doi:10.1038/228636a0 · Cited by 266
Studies in prebiotic synthesis
Ferris, J. P., Sanchez, R. A., & Orgel, L. E. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90314-8 · Cited by 253
Self-citationStudies in prebiotic synthesis
Sanchez, R. A., & Orgel, L. E. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90320-7 · Cited by 250
Self-citationUrea-Inorganic Phosphate Mixtures as Prebiotic Phosphorylating Agents
Lohrmann, R., & Orgel, L. E. (1971) · Science · doi:10.1126/science.171.3970.490 · Cited by 245
Self-citationKimball (1962) · doi:10.1016/0003-9861(62)90412-5 · Cited by 230
LOWE, C. U., REES, M. W., & MARKHAM, R. (1963) · Nature · doi:10.1038/199219a0 · Cited by 208
Synthesis of Adenosine Triphosphate Under Possible Primitive Earth Conditions
Ponnamperuma, C., Sagan, C., & Mariner, R. (1963) · Nature · doi:10.1038/199222a0 · Cited by 172
An Unusual Photochemical Rearrangement in the Synthesis of Adenine from Hydrogen Cyanide1
Ferris, J. P., & Orgel, L. E. (1966) · Journal of the American Chemical Society · doi:10.1021/ja00957a050 · Cited by 160
Self-citationCohn, W. E., & Doherty, D. G. (1956) · Journal of the American Chemical Society · doi:10.1021/ja01593a063 · Cited by 123
Studies in Prebiotic Synthesis. I. Aminomalononitrile and 4-Amino-5-cyanoimidazole1,2
Ferris, J. P., & Orgel, L. E. (1966) · Journal of the American Chemical Society · doi:10.1021/ja00968a028 · Cited by 121
Self-citationSeparation of Nucleoside Mixtures on Dowex-1 (OH-)1
Dekker, C. A. (1965) · Journal of the American Chemical Society · doi:10.1021/ja01095a073 · Cited by 113
Condensed Pyrimidine Systems. XXII. N-Methylpurines
Elion, G. B. (1962) · The Journal of Organic Chemistry · doi:10.1021/jo01054a045 · Cited by 107
Zur Kenntniss des Propargylaldehyds und des Phenylpropargylaldehyds
Claisen, L. (1903) · Berichte der deutschen chemischen Gesellschaft · doi:10.1002/cber.190303603168 · Cited by 97
Synthesis of Uracil under Conditions of a Thermal Model of Prebiological Chemistry
Fox, S. W., & Harada, K. (1961) · Science · doi:10.1126/science.133.3468.1923 · Cited by 91
Transphosphorylation from Nucleoside Di- and Triphosphates by Apatite Crystals
Krane, S. M., & Glimcher, M. J. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60262-5 · Cited by 89
Primordial Organic Chemistry. I. Compounds Resulting from Electron Irradiation of C14H4
Palm, C., & Calvin, M. (1962) · Journal of the American Chemical Society · doi:10.1021/ja00870a024 · Cited by 83
A NEW SYNTHESIS OF THE PURINES ADENINE, HYPOXANTHINE, XANTHINE, AND ISOGUANINE
Shaw, E. N. (1950) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56434-6 · Cited by 73
Ribose Phosphates: Production from Nucleotides, Ion-Exchange Separation and Characterization1
Khym, J. X., Doherty, D. G., & Cohn, W. E. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01650a075 · Cited by 69
Davoll, J., Lythgoe, B., & Todd, A. R. (1946) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9460000833 · Cited by 49
Substituted 2-Sulfonamido-5-aminopyridines. II
Caldwell, W. T., Tyson, F. T., & Lauer, L. (1944) · Journal of the American Chemical Society · doi:10.1021/ja01237a018 · Cited by 48
The Synthesis of 9-α-D-Ribofuranosyladenine
Wright, R. S., Tener, G. M., & Khorana, H. G. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01541a057 · Cited by 47
Optical rotatory dispersion of the anomeric nucleosides and nucleotides
Nishimura, T., Shimizu, B., & Iwai, I. (1968) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(68)90076-2 · Cited by 32
191. The decomposition of inorganic cyanates in water
Kemp, I., & Kohnstam, G. (1956) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9560000900 · Cited by 31
Synthesis of adenine and 4,5-dicyanoimidazole from hydrogen cyanide in liquid ammonia
Yamada, Y., Kumashiro, I., & Takenishi, T. (1968) · The Journal of Organic Chemistry · doi:10.1021/jo01266a036 · Cited by 29
THE STRUCTURE AND GRIGNARD REACTION OF THE β-AMINOCROTONONITRILE
Conn, J. J., & Taurinš, A. (1953) · Canadian Journal of Chemistry · doi:10.1139/v53-156 · Cited by 28
Synthesis of 1-(β-D-Ribofuranosyl) urea and Related Compounds.
Ukita, T., Hamada, A., & Yoshida, M. (1964) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.12.454 · Cited by 24
ARYLAMINE-N-GLYCOSIDES. PART I. ARYLAMINE-N-D-RIBOPYRANOSIDES AND N-D-RIBOFURANOSIDES
BERGER, L., & LEE, J. (1946) · The Journal of Organic Chemistry · doi:10.1021/jo01171a011 · Cited by 23
α-Cytidylsäure aus Heferibonucleinsäure
Gassen, H. G., & Witzel, H. (1965) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(65)90489-2 · Cited by 19
On the structure of neoguanosine
Shapiro, R., & Gordon, C. N. (1964) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(64)90138-x · Cited by 15
Purines, pyrimidines, and glyoxalines. Part I. New syntheses of glyoxalines and pyrimidines
Shaw, G. (1955) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9550001834 · Cited by 15
Separation of imidazoles by thin-layer chromatography
GRIMMETT, M. R., & Richards, E. C. M. (1965) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)80426-x · Cited by 13
A Convenient Synthesis of 4(5)-Amino-5(4)-imidazolecarboxamide Hydrochloride
Montgomery, J., Hewson, K., Struck, R. F., & Shealy, Y. F. (1959) · The Journal of Organic Chemistry · doi:10.1021/jo01084a630 · Cited by 10
Reactions of Nitriles. I. Synthesis of Propiolonitrile from Acetylene and Hydrocyanic Acid
Krebaum, L. J. (1966) · The Journal of Organic Chemistry · doi:10.1021/jo01350a054 · Cited by 9
THE REACTIONS OF ACTIVE NITROGEN WITH ACETYLENE, METHYLACETYLENE, AND DIMETHYLACETYLENE
Schavo, A., & Winkler, C. A. (1959) · Canadian Journal of Chemistry · doi:10.1139/v59-090 · Cited by 9
Research works printed but not linked: 2
- Chambers, 1964, Biochemistry, 3, 327
- Neuman, 1970, Currents in Modern Biology, 3, 253
Cited by
Sorted by citations
Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions.
Powner, M. W., Gerland, B., & Sutherland, J. D. (2009) · Nature · doi:10.1038/nature08013 · Cited by 1,383
Prebiotic chemistry and the origin of the RNA world.
Leslie E., O. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490460765 · Cited by 1,124
Self-citationThe antiquity of RNA-based evolution.
Joyce, G. F. (2002) · Nature · doi:10.1038/418214a · Cited by 1,070
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
RNA evolution and the origins of life
Joyce, G. F. (1989) · Nature · doi:10.1038/338217a0 · Cited by 658
Metadata
- Authors
- Fuller, W. D., Sanchez, R. A., & Orgel, L. E.
- Affiliations
- Salk Institute for Biological Studies (US)
- ORCID
- Sanchez, Robert A.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1972-06
- Volume
- 67
- Issue
- 1
- Pages
- 25-33
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W219287239
- Cited by
- 280
- References
- 36
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 5 · 2023: 5 · 2022: 11 · 2021: 12 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 12 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 9
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- prebiotic synthesis, adenine, ribose, magnesium catalysis, polyphosphate, inosine, adenosine, guanosine, guanine, hypoxanthine
- MeSH terms
- Adenine, Adenosine, Chemistry, Chromatography, Paper, Electrophoresis, Paper, Guanine, Guanosine, Hot Temperature, Hypoxanthines, Inosine, Kinetics, Magnesium, Nucleosides, Phosphates, Diphosphates, Ribonucleosides, Ribose, Chemical Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review