Identification and measurement of 18-hydroxycorticosterone metabolites by gas chromatography-mass spectrometry
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18-hydroxycorticosterone is converted to 18OHTHA, requiring additional conversion of the 11β-hydroxy group to an 11-keto group by HSD11B2.
“18-hydroxycorticosterone is converted to the tetrahydro metabolite, 18-hydroxy-tetrahydro-11-dehydrocorticosterone (18OHTHA), but this requires the additional conversion of the 11β-hydroxy group to an 11-keto group, a reaction catalyzed by HSD11B2 [[216], [217], [218]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [218]
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Self-citation
- Authors
- Shackleton, C. H. L., & Honour, J. W.
- ORCID
- Honour, J.W.
- Venue
- Journal of Steroid Biochemistry
- Publisher
- Elsevier BV
- Published
- 1977-03
- Volume
- 8
- Issue
- 3
- Pages
- 199-203
- ISSN
- 0022-4731 (ISSN-L)
- OpenAlex
- W2002402762
- Cited by
- 31
- References
- 17
- Citations by year
- 2023: 1 · 2019: 2
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Steroid Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Keywords
- urinary steroids, infants
- MeSH terms
- Chromatography, Gas, Corticosterone, Humans, Infant, Mass Spectrometry, 18-Hydroxycorticosterone
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