Prevention of exercise-induced muscle membrane damage by oestradiol

Bär, P.R.; Amelink, G.J.; Oldenburg, B.; Blankenstein, M.A.

doi:10.1016/0024-3205(88)90243-3

Cited by 133Exercise and Physiological ResponsesMuscle and Compartmental DisordersMuscle Physiology and Disorders

Prevention of exercise-induced muscle membrane damage by oestradiol

Bär, P.R., Amelink, G.J., Oldenburg, B., Blankenstein, M.A.·1988·Life Sciences

DOI 10.1016/0024-3205(88)90243-3

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Abstract

Exercise can damage the muscle membrane, followed by leakage of certain muscle proteins into the bloodstream. This postexercise response differs for males and females; as an explanation for this difference it has been suggested that oestrogens have a protective effect on the female muscle membrane. We recently developed an animal exercise model in which postexercise damage can be studied in laboratory animals in vivo. A postexercise dimorphism, similar to that in humans, exists in rats and indirect evidence for the involvement of oestradiol (E2) was found. We report here 1) that ovariectomized females show postexercise damage like males, 2) that this response can be prevented by E2-replacement before exercise, and 3) that males, after E2-treatment, no longer show postexercise muscle damage. We therefore conclude that oestradiol indeed plays an important role in protecting skeletal muscle, both in females and in males.

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Studies on muscle repair following exercise-induced injury highlight a sex-based difference in which higher levels of muscle creatine kinase (indicative of injury) are observed in male than in female rats following injury. Following OVX, levels of muscle creatine kinase in females are similar to levels in injured males.
“Studies on muscle repair following exercise-induced injury highlight a sex-based difference in which higher levels of muscle creatine kinase (indicative of injury) are observed in male than in female rats following injury. Following OVX, levels of muscle creatine kinase in females are similar to levels in injured males (3, 4, 8).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [8]

Non-genomic effects of steroids Interactions of steroid molecules with membrane structures and functions
Duval, D., Durant, S., & Homo-Delarche, F. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90008-4 · Cited by 264 · see citing works
Plasma creatine kinase changes after eccentric and concentric contractions
Newham, D. J., Jones, D. A., & Edwards, R. H. T. (1986) · Muscle & Nerve · doi:10.1002/mus.880090109 · Cited by 174 · see citing works
Increased serum creatine kinase after exercise
Shumate, J. B., Brooke, M. H., Carroll, J. E., & Davis, J. E. (1979) · Neurology · doi:10.1212/wnl.29.6.902 · Cited by 127 · see citing works
Effects of exercise on the serum concentrations of FSH, LH, progesterone, and estradiol
Bonen, A., Ling, W., MacIntyre, K. P., Neil, R., McGrail, J. C., & BELCASTRO, A. N. (1979) · European Journal of Applied Physiology · doi:10.1007/bf00421100 · Cited by 126 · see citing works
Exercise-induced muscle protein leakage in the rat
Amelink, G. J., & Bär, P. R. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90142-5 · Cited by 99 · see citing works
Self-citation
Estrogen binding proteins in rat skeletal and perineal muscles: in vitro and in vivo studies.
Dionne, F., Lesage, R., Dubé, J., & Tremblay, R. (1979) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(79)90156-0 · Cited by 59 · see citing works
The prolonged exercise test
Brooke, M. H., Carroll, J. E., Davis, J. E., & Hagberg, J. M. (1979) · Neurology · doi:10.1212/wnl.29.5.636 · Cited by 50 · see citing works
The use of steroid‐containing silastic implants in male nude mice: Plasma hormone levels and the effect of implantation on the weights of the ventral prostate and seminal vesicles
van Steenbrugge, G. J., Groen, M., de Jong, F. H., & Schroeder, F. H. (1984) · The Prostate · doi:10.1002/pros.2990050610 · Cited by 39 · see citing works
Myoglobin in the Very Early Phase of Acute Myocardial Infarction
McComb, J. M., McMaster, E. A., & Jadgey, A. A. (1985) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328502200208 · Cited by 30 · see citing works
The effect of subcutaneous administration of oestrogens on plasma oestrogen levels and tumour incidence in female rats
Blankenstein, M. A., Broerse, J. J., Vries, J. B. D., den Berg, K. J. V., Knaan, S., & van der Molen, H. J. (1977) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(77)90158-x · Cited by 17 · see citing works
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Estrogen effect on post-exercise skeletal muscle neutrophil infiltration and calpain activity
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Gender differences in skeletal muscle fibre damage after eccentrically biased downhill running in rats
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The Effect of Aging on Skeletal-Muscle Recovery from Exercise: Possible Implications for Aging Athletes
Fell, J. W., & Williams, A. D. (2008) · Journal of Aging and Physical Activity · doi:10.1123/japa.16.1.97 · Cited by 116 · see citing works
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AMELINK, G. J., KOOT, R. W., ERICH, W. B. M., VAN GIJN, J., & BÄR, P. R. (1990) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1990.tb08823.x · Cited by 109 · see citing works
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Chung, S.-C., Goldfarb, A. H., Jamurtas, A. Z., HEGDE, S. S., & Lee, J. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199903000-00009 · Cited by 60 · see citing works
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Amelink, G. J., Kamp, H. H., & Bär, P. R. (1988) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01907561 · Cited by 60 · see citing works
Self-citation
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Fisher, J., Hasser, E. M., & Brown, M. (1998) · Journal of applied physiology · doi:10.1152/jappl.1998.85.4.1316 · Cited by 59 · see citing works
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Warren, G. L., Lowe, D. A., Inman, C. L., Orr, O. M., Hogan, H. A., Bloomfield, S. A., & Armstrong, R. B. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.5.1660 · Cited by 56 · see citing works
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MacNeil, L., Baker, S. K., Stevic, I., & Tarnopolsky, M. A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00689.2009 · Cited by 56 · see citing works
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Yamamoto, T., Ohkuwa, T., Itoh, H., Sato, Y., & Naoi, M. (2002) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00097-2 · Cited by 55 · see citing works
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Oosthuyse, T., & Bosch, A. N. (2017) · Antioxidants · doi:10.3390/antiox6010016 · Cited by 49 · see citing works
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Rankin, P., Stevenson, E., & Cockburn, E. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3121-0 · Cited by 44 · see citing works
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Self-citation
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Ramamani, Aruldhas, & Govindarajulu, G. (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00554.x · Cited by 42 · see citing works
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Wolf, M. R., Fragala, M. S., Volek, J. S., Denegar, C. R., Anderson, J. M., Comstock, B. A., Dunn‐Lewis, C., Hooper, D. R., Szivak, T. K., Luk, H., et al. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2314-z · Cited by 38 · see citing works
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Hubal, M. J., & Clarkson, P. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90848.2008a · Cited by 36 · see citing works
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Tate, C. A., & HOLTZ, R. W. (1998) · Canadian Journal of Applied Physiology · doi:10.1139/h98-032 · Cited by 33 · see citing works
Extrinsic regulation of domestic animal-derived myogenic satellite cells II
Rhoads, R. P., Fernyhough, M. E., Liu, X., McFarland, D. C., Velleman, S. G., Hausman, G. J., & Dodson, M. V. (2009) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2008.12.005 · Cited by 31 · see citing works
Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones
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Dehydration and symptoms of delayed-onset muscle soreness in hyperthermic males.
Cleary, M. A., Sweeney, L. A., Kendrick, Z. V., & Sitler, M. R. (2005) · Europe PMC (PubMed Central) · Cited by 29 · see citing works
Sex differences in intracellular Ca2+ accumulation following eccentric contractions of rat skeletal muscle in vivo
Sonobe, T., Inagaki, T., Sudo, M., Poole, D. C., & Kano, Y. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00623.2009 · Cited by 29 · see citing works
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Colenso‐Semple, L. M., McKendry, J., Lim, C., Atherton, P. J., Wilkinson, D. J., Smith, K., & Phillips, S. M. (2024) · The Journal of Physiology · doi:10.1113/jp287342 · Cited by 28 · see citing works
Oral contraceptive pill use and the susceptibility to markers of exercise-induced muscle damage
Hicks, K. M., Onambélé-Pearson, G. L., Winwood, K. L., & Morse, C. I. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3629-6 · Cited by 28 · see citing works
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Pellegrini, M., Bulzomi, P., Galluzzo, P., Lecis, M., Leone, S., Pallottini, V., & Marino, M. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0425-3 · Cited by 26 · see citing works
The effect of prior eccentric exercise on heavy-intensity cycling: the role of gender and oral contraceptives
Joyce, S., Sabapathy, S., Bulmer, A. C., & MINAHAN, C. L. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2832-y · Cited by 25 · see citing works
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Mackay, K., Gonzalez, C., Zbinden-Foncea, H., & Peñailillo, L. E. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04254-y · Cited by 20 · see citing works
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Schrama, Y. C., Hen, R. J., de Jonge, N., Joles, J. A., van Rijn, H. J. M., r, D. R. B., Ververs, T. F., van Tol, A., & Koomans, H. A. (1998) · Transplantation · doi:10.1097/00007890-199811150-00011 · Cited by 24 · see citing works
Estradiol deficiency reduces the satellite cell pool by impairing cell cycle progression
Larson, A. A., Shams, A. S., McMillin, S. L., Sullivan, B. P., Vue, C., Roloff, Z. A., Batchelor, E., Kyba, M., & Lowe, D. A. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00429.2021 · Cited by 23 · see citing works
Estrogen effect on some enzymes of female rats after downhill running.
Sotiriadou, S. G., Kyparos, A., Mougios, V., Trontzos, C., Sidiras, G., & Matziari, C. (2003) · Physiological Research · doi:10.33549/physiolres.930400 · Cited by 23 · see citing works
Effect of alcohol after muscle-damaging resistance exercise on muscular performance recovery and inflammatory capacity in women
Levitt, D. E., Luk, H., Duplanty, A. A., McFarlin, B. K., Hill, D. W., & Vingren, J. L. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3606-0 · Cited by 23 · see citing works
Dantrolene sodium diminishes exercise-induced muscle damage in the rat
Amelink, G. J., Kallen, C., Wokke, J. H. J., & Bär, P. R. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90417-5 · Cited by 23 · see citing works
Self-citation
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Sotiriadou, S. G., Kyparos, A., Albani, M., Arsos, G. A., Clarke, M. S. F., Sidiras, G., Angelopoulou, N., & Matziari, C. (2006) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-008 · Cited by 22 · see citing works
Interleukin-6 and Delayed Onset Muscle Soreness Do Not Vary During the Menstrual Cycle
Chaffin, M. E., Berg, K. E., Meendering, J. R., Llewellyn, T. L., French, J. A., & Davis, J. E. (2011) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2011.10599806 · Cited by 21 · see citing works
The functional and molecular effects of problematic alcohol consumption on skeletal muscle: a focus on athletic performance
Cáceres-Ayala, C., Pautassi, R. M., Acuña, M. J., Cerpa, W. F., & Rebolledo, D. L. (2022) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2022.2041025 · Cited by 20 · see citing works
Estrogen administration, postexercise tissue oxidative stress and vitamin C status in male rats
Tiidus, P. M., Bombardier, É., Hidiroglou, N., & Madère, R. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-76-10-11-952 · Cited by 20 · see citing works
Effect of exercise on tissue anti-oxidant capacity and heart electrical properties in male and female rats
Venditti, P., Piro, M. C., Artiaco, G., & Meo, S. D. (1996) · European Journal of Applied Physiology · doi:10.1007/bf02226928 · Cited by 19 · see citing works
The role of the estrogen receptor in skeletal muscle mass homeostasis and regeneration
Diel, P. R. (2014) · Acta Physiologica · doi:10.1111/apha.12341 · Cited by 18 · see citing works
CK-MM Gene Polymorphism Does not Influence the Blood CK Activity Levels After Exhaustive Eccentric Exercise
Yamin, C., de Oliveira, J. J. F., Meckel, Y., Eynon, N., Sagiv, M. S., Ayalon, M., Alves, A. J., & Duarte, J. A. (2010) · International Journal of Sports Medicine · doi:10.1055/s-0029-1243256 · Cited by 18 · see citing works
Exercise and ovarian steroid hormones
Gigli, I., & Bussmann, L. E. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)00954-7 · Cited by 18 · see citing works
Influence of Ovarian Hormones on Strength Loss in Healthy and Dystrophic Female Mice
Kosir, A. M., Mader, T. L., Greising, A. G., Novotny, S. A., Baltgalvis, K. A., & Lowe, D. A. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000531 · Cited by 16 · see citing works
Exercise training fails to prevent glucocorticoid-induced muscle alterations in young growing rats
Fimbel, S., Abdelmalki, A., Mayet, M. H., SEMPORE, B., Koubi, H., Pugeat, M., Déchaud, H., & Favier, R. J. M. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374896 · Cited by 16 · see citing works
The effect of gradual ovarian failure on dynamic muscle function and the role of high-intensity interval training on mitigating impairments
Hubbard, E. F., Mashouri, P., Pyle, W. G., & Power, G. A. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00318.2023 · Cited by 15 · see citing works
Creatine kinase isoenzyme MB may be elevated in healthy young women after submaximal eccentric exercise.
Miles, M. P., & Schneider, C. M. (1993) · PubMed · Cited by 15 · see citing works
A rehabilitation exercise program to remediate skeletal muscle atrophy in an estrogen-deficient organism may be ineffective
Brown, M., Ferreira, J. A., Foley, A. M., & Hemmann, K. M. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1925-0 · Cited by 13 · see citing works
Effects of 17β-estradiol on turkey myogenic satellite cell proliferation, differentiation, and expression of glypican-1, MyoD and myogenin
McFarland, D. C., Pesall, J. E., Coy, C. S., & Velleman, S. G. (2013) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2013.01.001 · Cited by 12 · see citing works
Supplementation Strategies to Reduce Muscle Damage and Improve Recovery Following Exercise in Females: A Systematic Review
Köhne, J. L., Ormsbee, M. J., & McKune, A. J. (2016) · Sports · doi:10.3390/sports4040051 · Cited by 12 · see citing works
The effect of prolonged exercise on lipid peroxidation in eumenorrheic female runners
CASE, D., Baer, J. T., & Subbiah, M. T. R. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199910000-00005 · Cited by 12 · see citing works
Protective Effect of Estrogens Against Oxidative Damage to Heart and Skeletal Muscle In Vivo and In Vitro
Persky, A. M., Green, P. S., Stubley, L., Howell, C. O., Zaulyanov, L., Brazeau, G. A., & Simpkins, J. W. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1111/j.1525-1373.2000.22308.x · Cited by 12 · see citing works
The complex and bidirectional interaction between sex hormones and exercise performance in team sports with emphasis on soccer
Koundourakis, N. E., & Margioris, A. N. (2019) · HORMONES · doi:10.1007/s42000-019-00115-7 · Cited by 11 · see citing works
Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats.
Gigli, I., & Bussmann, L. E. (2002) · PubMed · Cited by 11 · see citing works
Effects of dietary protein on enzyme activity following exercise-induced muscle injury
Hayward, R., Ferrington, D. A., KOCHANOWSKI, L. A., Miller, L., JAWORSKY, G. M., & Schneider, C. M. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199903000-00010 · Cited by 11 · see citing works
INFLUENCE OF ESTROGEN ON MUSCLE PLASTICITY
Tiidus, P. M. (2011) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 9 · see citing works
Effects of a low carbohydrate diet and graded exercise during the follicular and luteal phases on the blood antioxidant status in healthy women
Kłapcińska, B., Sadowska‐Krępa, E., Manowska, B., Pilis, W., Sobczak, A., & Danch, A. (2002) · European Journal of Applied Physiology · doi:10.1007/s00421-002-0641-1 · Cited by 7 · see citing works
Systems Physiology : Skeletal Muscle EFFECTS OF CIRCULATING ESTRADIOL ON EXERCISE-INDUCED CREATINE KINASE ACTIVITY
Roth, S. M., Gajdosik, R. L., & Ruby, B. C. (2001) · Cited by 7 · see citing works
Hormonal Receptors in Skeletal Muscles of Dystrophic Mdx Mice
Feder, D., Godoy, I. R. B., Pereira, M. L. G., da Silva, C. S., Silvestre, D. N., Fonseca, F. L. A., Carvalho, A. A. D. S., Eichler, R. A. D. S., & Carvalho, M. H. C. (2012) · BioMed Research International · doi:10.1155/2013/604635 · Cited by 6 · see citing works
Effects of Exercise on Muscle Metabolites and Sarcoplasmic Reticulum Function in Ovariectomized Rats Treatment.
Gigli, I., & Bussmann, L. (2002) · Physiological Research · doi:10.33549/physiolres.930175 · Cited by 6 · see citing works
Local and systemic responses to repeated gluteal muscle microbiopsies in mature sedentary horses
Artman, J. L., Wesolowski, L. T., Semanchik, P. L., Isles, J. K., Norton, S. A., & White-Springer, S. H. (2024) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2024.105070 · Cited by 5 · see citing works
Nerve Growth Factor and Estrogen Receptor mRNA Expression in Paravertebral Muscles of Patients With Adolescent Idiopathic Scoliosis: A Preliminary Study
Kudo, D., Miyakoshi, N., Hongo, M., Matsumoto, K., Kasukawa, Y., Misawa, A., Ishikawa, Y., & Shimada, Y. (2015) · Spine Deformity · doi:10.1016/j.jspd.2014.07.006 · Cited by 5 · see citing works
Sex Differences in the Oxygenation of the Left and Right Prefrontal Cortex during Moderate-Intensity Exercise
Inagaki, Y., Sato, R., Uchiyama, T., Kojima, S., Morishita, S., Qin, W., & Tsubaki, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18105212 · Cited by 5 · see citing works
Genetic polymorphisms in CYP19A1 and ESR1 are associated with serum CK activity after prolonged running in men
Kumagai, H., Miyamoto‐Mikami, E., Takaragawa, M., Kuriki, K., Goto, C., Shibata, K., Yamada, N., Hosono, A., Fuku, M., Suzuki, S., et al. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00374.2021 · Cited by 5 · see citing works

Exercise-induced muscle protein leakage in the rat
Amelink, G. J., & Bär, P. R. (1986) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(86)90142-5 · Cited by 99 · see citing works
Self-citation
The role of oestrogen in exercise-induced muscle damage.
Kendall, B. (2003) · Bangor University Research Portal (Bangor University)
. Effects of Estrogen on Muscle Damage in Response to an Acute Resistance Exercise Protocol
Theses, H. S., Wolf, M. R., & Wolf, M. R. (2014)
Can Estrogens Diminish Exercise Induced Muscle Damage?
Tiidus, P. M. (1995) · Canadian Journal of Applied Physiology · doi:10.1139/h95-002 · Cited by 98 · see citing works
Estrogen and Gender Effects on Muscle Damage, Inflammation, and Oxidative Stress
Tiidus, P. M. (2000) · Canadian Journal of Applied Physiology · doi:10.1139/h00-022 · Cited by 167 · see citing works

Authors: Bär, P. R., Amelink, G. J., Oldenburg, B., & Blankenstein, M. A.
Affiliations: Utrecht University (NL)
ORCID: Oldenburg, B.
Blankenstein, M.A.
Venue: Life Sciences
Publisher: Elsevier BV
Published: 1988-01
Volume: 42
Issue: 26
Pages: 2677-2681
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/0024-3205(88)90243-3
OpenAlex: W2029497561
Cited by: 133
References: 10
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 2 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 4
FWCI: 3.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Surgery › Muscle and Compartmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: exercise-induced muscle damage, estradiol, ovariectomy, sex differences, estrogen replacement therapy, rats
MeSH terms: Animals, Aspartate Aminotransferases, Cell Membrane Permeability, Creatine Kinase, Estradiol, Physical Exertion, Female, Male, Ovariectomy, Sarcolemma, Rats

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Prevention of exercise-induced muscle membrane damage by oestradiol

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