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Cited by 109Muscle Physiology and DisordersEstrogen and related hormone effectsExercise and Physiological Responses

Sex‐linked variation in creatine kinase release, and its dependence on oestradiol, can be demonstrated in an in‐vitro rat skeletal muscle preparation

AMELINK, G. J., KOOT, R. W., ERICH, W. B. M., VAN GIJN, J., BÄR, P. R.·1990·Acta Physiologica Scandinavica
DOI 10.1111/j.1748-1716.1990.tb08823.x
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Abstract

Creatine kinase (CK) release from male and female rat soleus muscles was studied for 4.5 h in vitro, under basal conditions and after electrical stimulation. Basal CK release was greater from male than from female muscles, and CK release from male muscles increased significantly when the muscle tension in the in‐vitro set‐up was increased. CK release after electrical stimulation was also more marked in male soleus muscles. Pretreatment of male rats and ovariectomized female rats with oestradiol for 3 weeks attenuated the enzyme efflux, but ovariectomy 24 h before in females, or oestradiol administration 24 h before in males, did not affect the release of CK in vitro. The data show that sex‐linked differences in CK efflux are still present, under both basal and stimulated conditions, when muscles are isolated from the intact animal, and that hormone treatment of the intact animal affects these properties in the isolated muscle in vitro. (Experiments with rats were performed under supervision of a legally appointed administrator.)

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Crossref · 10.1111/j.1748-1716.1990.tb08823.x

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41 of 41 references verified0 citation errors · 0 not checkable

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  • Studies on muscle repair following exercise-induced injury highlight a sex-based difference in which higher levels of muscle creatine kinase (indicative of injury) are observed in male than in female rats following injury. Following OVX, levels of muscle creatine kinase in females are similar to levels in injured males.

    “Studies on muscle repair following exercise-induced injury highlight a sex-based difference in which higher levels of muscle creatine kinase (indicative of injury) are observed in male than in female rats following injury. Following OVX, levels of muscle creatine kinase in females are similar to levels in injured males (3, 4, 8).”

    From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [4]

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Authors
AMELINK, G. J., KOOT, R. W., ERICH, W. B. M., VAN GIJN, J., & BÄR, P. R.
Affiliations
Utrecht University (NL)
Corresponding author
BÄR, P. R.
ORCID
KOOT, R. W.
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
1990-02
Volume
138
Issue
2
Pages
115-124
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
DOI
10.1111/j.1748-1716.1990.tb08823.x
OpenAlex
W2085905912
Cited by
109
References
41
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 4 · 2013: 4 · 2012: 4
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6885 d)
Locations
  • Acta Physiologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
creatine kinase release, sex differences, estradiol, skeletal muscle, soleus muscle, electrical stimulation, ovariectomy, isolated muscle preparation, muscle tension, rats
MeSH terms
Animals, Cell Membrane Permeability, Creatine Kinase, Electric Stimulation, Estradiol, Female, Male, Muscle Tonus, Muscles, Rats, Inbred Strains, Sex Factors, Rats, In Vitro Techniques

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