The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.
Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease
Abstract
In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-1), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.
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“However, the intercellular adhesion molecule-1 (ICAM-1) was shown to be highly expressed in endothelial cells of AD patients.486”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [486]
In the citing paper
“Experimental evidence confirmed that biomarkers of endothelial dysfunction, such as intercellular adhesion molecule 1 (ICAM-1), are increased in AD; endothelial cells, astrocytes and microglia show enhanced levels of ICAM-1 in pathological states”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [146]
In the citing paper
“and this plays a role in neuritic plaques on neurite growth and neurodegeneration [145,146,147].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [146]
Citations
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Metadata
- Authors
- Frohman, E. M., Frohman, T. C., Gupta, S., de Fougerolles, A., & van den Noort, S.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Frohman, Elliot M.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1991-11
- Volume
- 106
- Issue
- 1
- Pages
- 105-111
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W1968283018
- Cited by
- 120
- References
- 18
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 00538)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- ICAM-1, Alzheimer's disease, ICAM-2, LFA-1, HLA-DR, neuritic plaques, cerebrovascular endothelium, microglial cells, leukocytes, antigen presentation, glial cells, neurodegeneration, neurite outgrowth
- MeSH terms
- Alzheimer Disease, Cerebral Arteries, Endothelium, Vascular, HLA-DR Antigens, Humans, Macrophages, Nerve Tissue Proteins, Neuroglia, Biomarkers, Antigens, CD, Cell Adhesion Molecules, Lymphocyte Function-Associated Antigen-1, Intercellular Adhesion Molecule-1
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