Cited by 121Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.

Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease

Frohman, Elliot M., Frohman, Teresa C., Gupta, Sudhir, de Fougerolles, Antonin, van den Noort, Stanley·1991·Journal of the Neurological Sciences

DOI 10.1016/0022-510x(91)90202-i

Open this paper in CoChat — free account

Abstract

In this study, 13 clinically and pathologically diagnosed cases of Alzheimer's disease were analyzed for the presence of intercellular adhesion molecule 1 (ICAM-1), ICAM-2, lymphocyte function associated antigen-1 (LFA-1), HLA-DR, LN-1, and LN-2. ICAM-1 was observed primarily on neuritic plaques and cerebrovascular endothelium. ICAM-1 was also shown to be present in brain tissue derived from 14 normal cases; however, the degree of immunoreactivity was quantitatively less compared to Alzheimer cases and was largely restricted to cerebrovascular endothelium. LFA-1 was shown to be present on microglial cells and leukocytes. Consistent with the findings of previous reports, HLA-DR was found to be expressed on microglial cells. In this study we failed to demonstrate dual immunolocalization for ICAM-1 and LFA-1, ICAM-1 and HLA-DR, or ICAM-1 and LN-2. As microglial cells express both HLA-DR and LFA-1, they may serve to mediate antigen presentation functions by interacting with lymphocyte ICAM-1. Alternately, the expression of these immune-associated glycoproteins on glial cells may be epiphenomenal occurring secondary to some aspect of the disease process. Finally, the presence of ICAM-1 within neuritic plaques raises the question as to whether adhesion may play some role in the process of neurite outgrowth and neurodegeneration.

Integrity signals

Registry

Crossref · 10.1016/0022-510x(91)90202-i

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

New Perspectives in Cell Adhesion: RGD and Integrins
Ruoslahti, E. I., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,875
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.1.245 · Cited by 2,450
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.
Rothlein, R., Dustin, M. L., Marlin, S. D., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.4.1270 · Cited by 1,400
Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease
Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743
ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM
Simmons, D., Makgoba, M. W., & Seed, B. (1988) · Nature · doi:10.1038/331624a0 · Cited by 616
Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor
Griffiths, C. E. M., Voorhees, J. J., & Nickoloff, B. J. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70073-6 · Cited by 503
Antigen presentation: comments on its regulation and mechanism.
Unanue, E. R., Beller, D. I., Lu, C., & Allen, P. M. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.1.1 · Cited by 497
Brain microglia constitutively express β-2 integrins
Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90055-r · Cited by 430
Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
McGeer, P. L., Itagaki, S., & McGeer, E. G. (1988) · Acta Neuropathologica · doi:10.1007/bf00689592 · Cited by 420

Show all 18 references

Research works printed but not linked: 3

Del Rio Hortega, 1932, Microglia, Vol. 2, 483
Frohman, 1989, Expression of intercellular adhesion molecule 1 in Alzheimer's disease, Ann. Neurol., 26, 122
Traugott, 1989, Role of adhesion molecules in the immunopathogenesis of multiple sclerosis lesions, Neurology, 39, 171

Sorted by citations

Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668
“However, the intercellular adhesion molecule-1 (ICAM-1) was shown to be highly expressed in endothelial cells of AD patients.(486) In vitro stimulating of human brain endothelial cells with Aβ or TNF-α induced the expression of endothelial adhesion molecules, including selectin, ICAM-1, and vascular cell adhesion prot…”
Background
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
MCGEER, P., & MCGEER, E. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00011-9 · Cited by 1,287
The blood-brain barrier in Alzheimer’s disease
Zenaro, E., Piacentino, G., & Constantin, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.007 · Cited by 767
Neuroinflammation Induces Neurodegeneration.
Kempuraj, D., Thangavel, R., Natteru, P., Selvakumar, G. P., Saeed, D., Zahoor, H., Zaheer, S., Iyer, S. S., & Zaheer, A. (2016) · PubMed · Cited by 675
Microglia in degenerative neurological disease
McGeer, P. L., Kawamata, T., Walker, D. G., Akiyama, H., Tooyama, I., & McGeer, E. G. (1993) · Glia · doi:10.1002/glia.440070114 · Cited by 596
Inflammation and Alzheimer's disease pathogenesis
Rogers, J., Webster, S. D., Lue, L., Brachova, L., CIVIN, W. H., Emmerling, M. R., Shivers, B. D., Walker, D. G., & McGeer, P. L. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00115-7 · Cited by 438
Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease
Grammas, P. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-26 · Cited by 432
Selective expression of adhesion molecules on human brain microvascular endothelial cells
Stins, M. F., Gilles, F. H., & Kim, K. S. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00036-2 · Cited by 363
Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer’s disease and vascular dementia
Tarkowski, E., Issa, R., Sjögren, M., Wallin, A., Blennow, K., Tarkowski, A., & Kumar, P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00285-8 · Cited by 360
Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy
Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339
Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
Grammas, P. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00276-7 · Cited by 298
Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles
Marco, L. Y. D., Venneri, A., Farkas, E., Evans, P. C., Marzo, A., & Frangi, A. F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.014 · Cited by 260
The role of complement and activated microglia in the pathogenesis of Alzheimer's disease
Eikelenboom, P., & Veerhuis, R. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00108-x · Cited by 206
The Blood‐Brain Barrier and Cerebrovascular Pathology in Alzheimer's Disease
Kalaria, R. N. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07821.x · Cited by 196
Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity
Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 189
Identification of oxidized plasma proteins in Alzheimer's disease
Choi, J., Malakowsky, C. A., Talent, J. M., Conrad, C. C., & Gracy, R. W. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00420-5 · Cited by 181
Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease
Devassy, J. G., Leng, S., Gabbs, M., Monirujjaman, M., & Aukema, H. M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012187 · Cited by 192
Tau Protein and Its Role in Blood–Brain Barrier Dysfunction
Michalicová, A., Majerová, P., & Kováč, A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.570045 · Cited by 185
Silver nanoparticles (AgNPs) cause degeneration of cytoskeleton and disrupt synaptic machinery of cultured cortical neurons
Xu, F., Piett, C. G., Farkas, S., Qazzaz, M., & Syed, N. I. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-29 · Cited by 181
Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte–endothelial interactions
Rossi, B., Angiari, S., Zenaro, E., Budui, S. L., & Constantin, G. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0710432 · Cited by 172
Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
Arendt, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00516-9 · Cited by 172
Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer’s Disease-Like Pathology, Blood–Brain Barrier Disruption, and Synaptic Disorder
Kamat, P. K., Kyles, P., Kalani, A., & Tyagi, N. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9212-4 · Cited by 163
Morphological and Biochemical Analyses of Amyloid Plaque Core Proteins Purified from Alzheimer Disease Brain Tissue
Roher, A. E., Palmer, K. C., Yurewicz, E. C., Ball, M. J., & Greenberg, B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09834.x · Cited by 144
α-Synuclein Expression Modulates Microglial Activation Phenotype
Austin, S. A., Floden, A. M., Murphy, E. J., & Combs, C. K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1799-06.2006 · Cited by 150
Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders
Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L. (1993) · Acta Neuropathologica · doi:10.1007/bf00334673 · Cited by 137
Structure and function of amyloid in Alzheimer's disease
Morgan, C., Colombres, M., Núñez, M. T., & Inestrosa, N. C. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.10.004 · Cited by 146
A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly
Fard, M. T., & Stough, C. K. K. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00056 · Cited by 124
An Integrated View on Vascular Dysfunction in Alzheimer’s Disease
Klohs, J. (2019) · Neurodegenerative Diseases · doi:10.1159/000505625 · Cited by 111
Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease
Chang, R., Knox, J., Chang, J. H., Derbedrossian, A., Vasilevko, V., Cribbs, D. H., Boado, R. J., Pardridge, W. M., & Sumbria, R. K. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00200 · Cited by 116
Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid β-Induced Neuronal Dystrophy
Grace, E. A., & Busciglio, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00493.2003 · Cited by 113
Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome
Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9379-2 · Cited by 114
Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.
(1994) · PubMed Central · Cited by 105
Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations?
Cotman, C. W., Hailer, N. P., Pfister, K. K., Soltész, I., & Schachner, M. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00025-2 · Cited by 100
Beneficial Effects of Spirulina Consumption on Brain Health
Trotta, T., Porro, C., Cianciulli, A., & Panaro, M. A. (2022) · Nutrients · doi:10.3390/nu14030676 · Cited by 98
Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
Uranga, R. M., Bruce‐Keller, A. J., Morrison, C. D., Fernandez‐Kim, S. O., Ebenezer, P. J., Zhang, L., Dasuri, K., & Keller, J. N. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06803.x · Cited by 90
Type 2 Diabetic and Alzheimer's Disease Mice Present Similar Behavioral, Cognitive, and Vascular Anomalies
Carvalho, C., Machado, N. J., Mota, P. C., Correia, S. C., Cardoso, S., Santos, R. X., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130005 · Cited by 88
Cadmium stimulates the expression of ICAM-1 via NF-κB activation in cerebrovascular endothelial cells
Jeong, E.-M., Moon, C., Kim, C., Lee, S., Baik, E. J., Moon, C.-K., & Jung, Y. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.218 · Cited by 84
Soluble adhesion molecules and angiotensin-converting enzyme in dementia
Nielsen, H. M., Londos, E., Minthon, L., & Janciauskiene, S. M. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.11.011 · Cited by 80
Imaging of cerebrovascular pathology in animal models of Alzheimer's disease
Klohs, J., Rudin, M., Shimshek, D. R., & Beckmann, N. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00032 · Cited by 82
A damaged microcirculation contributes to neuronal cell death in Alzheimer’s disease☆
Grammas, P. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00102-0 · Cited by 81
Molecular Basis of Etiological Implications in Alzheimer’s Disease: Focus on Neuroinflammation
Niranjan, R. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8428-4 · Cited by 83
Amyloid beta acts synergistically as a pro-inflammatory cytokine
LaRocca, T. J., Cavalier, A. N., Roberts, C. M., Lemieux, M. R., Ramesh, P., Garcia, M. A., & Link, C. D. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105493 · Cited by 83
Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease
Eikelenboom, P., Zhan, S., Kamphorst, W., van der Valk, P., & Rozemüller, A. J. M. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00190565 · Cited by 78
Risk Factors for Alzheimer’s Disease: Role of Multiple Antioxidants, Non-Steroidal Anti-inflammatory and Cholinergic Agents Alone or in Combination in Prevention and Treatment
Prasad, K. N., Cole, W. C., & Prasad, K. C. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719249 · Cited by 76
Piriform cortex efferents to the entorhinal cortex in vivo: kindling-induced potentiation and the enhancement of long-term potentiation by low-frequency piriform cortex or medial septal stimulation
Chapman, C. A., & Racine, R. J. (1997) · Hippocampus · doi:10.1002/(sici)1098-1063(1997)7:3 · Cited by 28
Multiple Antioxidants in the Prevention and Treatment of Alzheimer Disease: Analysis of Biologic Rationale
Prasad, K. N., Hovland, A. R., Cole, W. C., Prasad, K. C., Nahreini, P., Edwards‐Prasad, J., & Andreatta, C. P. (2000) · Clinical Neuropharmacology · doi:10.1097/00002826-200001000-00002 · Cited by 75
Apelin, a promising target for Alzheimer disease prevention and treatment
Masoumi, J., Abbasloui, M., Parvan, R., Mohammadnejad, D., Pavon‐Djavid, G., Barzegari, A., & Abdolalizadeh, J. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.05.008 · Cited by 70
Microglial interaction with β‐amyloid: Implications for the pathogenesis of Alzheimer's disease
Bamberger, M. E., & Landreth, G. E. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1121 · Cited by 74
Adhesion molecule expression on murine cerebral endothelium following the injection of a proinflammagen or during acute neuronal degeneration
Bell, M. D., & Perry, V. H. (1995) · Journal of Neurocytology · doi:10.1007/bf01179819 · Cited by 70
The Immunopathology of Alzheimer's Disease and Some Related Disorders
Kalaria, R. N. (1993) · Brain Pathology · doi:10.1111/j.1750-3639.1993.tb00761.x · Cited by 69
Anti-Selectin Therapy for the Treatment of Inflammatory Diseases
Rossi, B., & Constantin, G. (2008) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152808785107633 · Cited by 66
Cell adhesion molecules in Alzheimer's disease
Nielsen, H. M., & Wennström, M. (2012) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s19829 · Cited by 60
Expression of CAP37, a Novel Inflammatory Mediator, in Alzheimer's Disease
Pereira, H. A., Kumar, P., & Grammas, P. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00118-2 · Cited by 61
Expression of CAP37, a Novel Inflammatory Mediator, in Alzheimer's Disease
Pereira, H. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00118-2 · Cited by 62
The exploration of novel Alzheimer’s therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches
Hassan, M., Raza, H., Abbasi, M. A., Moustafa, A. A., & Seo, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.115 · Cited by 62
Relationship between Inflammatory Mediators, A? Levels and ApoE Genotype in Alzheimer Disease
Reale, M., Kamal, M. A., Velluto, L., Gambi, D., Nicola, M. D., & Greig, N. H. (2012) · Current Alzheimer Research · doi:10.2174/156720512800492549 · Cited by 52
Indices of low-grade chronic inflammation correlate with early cognitive deterioration in an elderly Greek population
Dimopoulos, N. P., Piperi, C., Salonicioti, A., Mitropoulos, P., Kallai, E., Liappas, I., Lea, R. W., & Kalofoutis, A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.12.064 · Cited by 51
Serum Levels of Soluble Intercellular Adhesion Molecule-1 and Soluble Endothelial Leukocyte Adhesion Molecule-1 in Alzheimer’s Disease
Rentzos, M., Michalopoulou, M., Nikolaou, C., Cambouri, C., Rombos, A., Dimitrakopoulos, A., Kapaki, E., & Vassilopoulos, D. (2004) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704269822 · Cited by 50
The role of soluble intercellular adhesion molecules in neurodegenerative disorders
Rentzos, M., Michalopoulou, M., Nikolaou, C., Cambouri, C., Rombos, A., Dimitrakopoulos, A., & Vassilopoulos, D. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.11.001 · Cited by 45
Biomarkers Assessing Endothelial Dysfunction in Alzheimer’s Disease
Custodia, A., Aramburu-Núñez, M., Rodríguez‐Arrizabalaga, M., Peleteiro, J. M. P., Vázquez‐Vázquez, L., Camino-Castiñeiras, J., Aldrey, J. M., Castillo, J., Ouro, A., Sobrino, T., et al. (2023) · Cells · doi:10.3390/cells12060962 · Cited by 47
Activation of microglia: A neuroinflammatory role for CAP37
Pereira, H., Ruan, X.-J., & Kumar, P. (2003) · Glia · doi:10.1002/glia.10167 · Cited by 42
Decreased Release of the Angiogenic Peptide Vascular Endothelial Growth Factor in Alzheimer’s Disease: Recovering Effect with Insulin and DHEA Sulfate
Solerte, S. B., Ferrari, E., Cuzzoni, G., Locatelli, E., Giustina, A., Zamboni, M. M., Schifino, N., Rondanelli, M., Gazzaruso, C., & Fioravanti, M. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000080963 · Cited by 41
Thrombin, a Key Driver of Pathological Inflammation in the Brain
Iannucci, J., & Grammas, P. (2023) · Cells · doi:10.3390/cells12091222 · Cited by 40
Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer’s disease
Piniella‐Matamoros, B., Marín‐Prida, J., & Pentón‐Rol, G. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00161-7 · Cited by 34
Distribution of ICAM-1 immunoreactivity during aging in the human orbitofrontal cortex
Miguel-Hidalgo, J. J., Nithuairisg, S., Stockmeier, C. A., & Rajkowska, G. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.05.001 · Cited by 33
Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology
Walker, D. G., Lue, L.-F., Tang, T. M., Adler, C. H., Caviness, J. N., Sabbagh, M. N., Serrano, G. E., Sue, L. I., & Beach, T. G. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.03.007 · Cited by 33
The vascular contribution to cognitive decline in ageing and dementia
Anderle, S., Dixon, M., Quintela‐López, T., Sideris-Lampretsas, G., & Attwell, D. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00950-1 · Cited by 40
Intercellular adhesion molecule-1 K469E gene polymorphism and Alzheimer’s disease
Pola, R., Flex, A., Gaetani, E., Santoliquido, A., Serricchio, M., Pola, P., & Bernabei, R. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00087-8 · Cited by 32
Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease
Lei, T., Yang, Z., Li, H., Qin, M., & Gao, H. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115219 · Cited by 34
High Glucose and Hypoxia-Mediated Damage to Human Brain Microvessel Endothelial Cells Induces an Altered, Pro-Inflammatory Phenotype in BV-2 Microglia In Vitro
Iannucci, J., Rao, H. V., & Grammas, P. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00987-z · Cited by 33
Unusual Aspects of Inflammation in the Nervous System: Wallerian Degeneration
Castaño, A., Bell, M. D., & Perry, V. H. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00105-4 · Cited by 32
Brown rats on farmland
Macdonald, D. W., Berdoy, M., & Webster, J. P. (2015) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198745501.003.0011 · Cited by 27
Neuroimmune nexus of depression and dementia: Shared mechanisms and therapeutic targets
Herman, F. J., Simkovic, S. J., & Pasinetti, G. M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14569 · Cited by 29
Colonisation of the human central nervous system by microglia: the roles of chemokines and vascular adhesion molecules
Male, D. K., & Rezaie, P. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)32067-8 · Cited by 26
Mapping the dynamics of insulin-responsive pathways in the blood–brain barrier endothelium using time-series transcriptomics data
Wang, Z., Tang, X., Swaminathan, S. K., Kandimalla, K. K., & Kalari, K. R. (2022) · npj Systems Biology and Applications · doi:10.1038/s41540-022-00235-8 · Cited by 24
Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease
Miller, M. R., Landis, H. E., Miller, R. E., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13181554 · Cited by 26
Inhibition of Early Upstream Events in Prodromal Alzheimer’s Disease by Use of Targeted Antioxidants
Prasad, K. N., & Bondy, S. C. (2014) · Current Aging Science · doi:10.2174/1874609807666140804115633 · Cited by 24
Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?
Ritson, M., Wheeler-Jones, C. P. D., & Stolp, H. B. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578363 · Cited by 23
sPDGFRβ and neuroinflammation are associated with AD biomarkers and differ by race: The ASCEND Study
Butts, B., Huang, H., Hu, W. T., Kehoe, P. G., Miners, J. S., Verble, D. D., Zetterberg, H., Zhao, L., Trotti, L. M., Benameur, K., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13457 · Cited by 20
β-Amyloid-associated expression of intercellular adhesion molecule-1 in brain cortical tissue of transgenic Tg2576 mice
Apelt, J., Leßig, J., & Schliebs, R. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00589-x · Cited by 21
Inflammatory Mediators in Alzheimer’s Disease
Rogers, J., & O’Barr, S. A. (1997) · Humana Press eBooks · doi:10.1007/978-1-59259-471-9_11 · Cited by 19
Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer’s disease
Gunawan, C., Fleming, C. L., Irga, P. J., Wong, R. J., Amal, R., Torpy, F. R., Golzan, M., & McGrath, K. C. Y. (2024) · Environment International · doi:10.1016/j.envint.2024.108512 · Cited by 23
Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells
Hanson, A. J., Prasad, J. E., Nahreini, P., Andreatta, C. P., Kumar, B., Yan, X., & Prasad, K. N. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10726 · Cited by 20
Inflammation in Alzheimer's disease: a view from the periphery
Raine, C. S. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00138-x · Cited by 20
Production of Neurotoxic Factors by Brain Endothelium in Alzheimer's Diseasea
Grammas, P., Botchlet, T., Moore, P., & Weigel, P. H. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48460.x · Cited by 19
A link between sICAM-1, ACE and parietal blood flow in the aging brain
Janciauskiene, S. M., Erikson, C. A., & Warkentin, S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.025 · Cited by 19
CX3CL1 induces cell migration and invasion through ICAM ‐1 expression in oral squamous cell carcinoma cells
Wu, C., Peng, P., Renn, T., Lee, C., Chang, T., Wei, A. I., & Liu, J. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17750 · Cited by 17
Nanowire array chips for molecular typing of rare trafficking leukocytes with application to neurodegenerative pathology
Kwak, M., Kim, D., Lee, M.-R., Wu, Y., Han, L. G., Lee, S., & Fan, R. (2014) · Nanoscale · doi:10.1039/c3nr06465d · Cited by 16
Cerebrovasculature‐mediated Neuronal Cell Death
Grammas, P., Reimann‐Philipp, U., & Weigel, P. H. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06350.x · Cited by 15
Role of hydrogen sulfide in cerebrovascular alteration during aging
Mun, J., Kang, H.-M., Jung, J., & Park, C. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01135-y · Cited by 14
Do Nonsteroidal Anti-Inflammatory Drugs Have a Protective Effect Against Dementia?
Muiswinkel, F. L. V., & Eikelenboom, P. (1996) · Drugs & Aging · doi:10.2165/00002512-199609010-00001 · Cited by 15
Roles of CNS Macrophages in Neurodegeneration
Wood, P. L. (1998) · Humana Press eBooks · doi:10.1007/978-1-59259-473-3_1 · Cited by 14
Inflammatory Mechanisms of Alzheimer’s Disease
Rogers, J., & Griffin, W. S. T. (1998) · Humana Press eBooks · doi:10.1007/978-1-59259-473-3_6 · Cited by 14
Inhibition of Monocyte Adhesion to Brain-Derived Endothelial Cells by Dual Functional RNA Chimeras
Hu, J., Xiao, F., Hao, X., Bai, S., & Hao, J. (2014) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.60 · Cited by 13
T-Cell Interferon Gamma Binding in Patients With Dementia of the Alzheimer Type
Bongioanni, P., Boccardi, B., Borgna, M., Castagna, M., & Mondino, C. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550160085021 · Cited by 13
Recurrent audiovestibular disturbance initially mimicking Ménière’s disease in a patient with anterior inferior cerebellar infarction
Park, J., Kim, H., & Han, H.-J. (2008) · Neurological Sciences · doi:10.1007/s10072-008-0996-0 · Cited by 12
Inflammaging: inflammation and oxidative stress as a cause of aging and cognitive decline
Pereverzev, A. P., Romanovsky, R. R., Shatalova, N. A., & Ostroumova, O. D. (2021) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2021-4-48-58 · Cited by 11
Integrated Bulk and Single-Cell RNA-Sequencing Reveals the Effects of Circadian Rhythm Disruption on the Metabolic Reprogramming of CD4+ T Cells in Alzheimer’s Disease
Weng, W., Fu, J., Fan, C., Wang, Y., & Zhang, J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03907-6 · Cited by 7
Investigating the Relationship between Diabetes and Alzheimer’s Disease:
Sahrawat, T. R., & Dwivedi, J. (2020) · Journal of Science and Sustainable Development · doi:10.4314/jssd.v7i1.1 · Cited by 6
Genetically proxied IL‐6 signaling and risk of Alzheimer's disease and lobar intracerebral hemorrhage: A drug target Mendelian randomization study
Myserlis, E. P., Ray, A., Anderson, C. D., & Georgakis, M. K. (2024) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70000 · Cited by 5

Authors: Frohman, E. M., Frohman, T. C., Gupta, S., de Fougerolles, A., & van den Noort, S.
Affiliations: University of California, Irvine (US)
Corresponding author: Frohman, Elliot M.
ORCID: Frohman, Elliot M.
Gupta, Sudhir
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 1991-11
Volume: 106
Issue: 1
Pages: 105-111
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/0022-510x(91)90202-i
OpenAlex: W1968283018
Cited by: 120
References: 18
Citations by year: 2025: 2 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 3
FWCI: 1.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 00538)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: ICAM-1, Alzheimer's disease, ICAM-2, LFA-1, HLA-DR, neuritic plaques, cerebrovascular endothelium, microglial cells, leukocytes, antigen presentation, glial cells, neurodegeneration, neurite outgrowth
MeSH terms: Alzheimer Disease, Cerebral Arteries, Endothelium, Vascular, HLA-DR Antigens, Humans, Macrophages, Nerve Tissue Proteins, Neuroglia, Biomarkers, Antigens, CD, Cell Adhesion Molecules, Lymphocyte Function-Associated Antigen-1, Intercellular Adhesion Molecule-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks