Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders
Abstract
Intercellular adhesion molecule-1 (ICAM-1) was localized immunohistochemically in postmortem brain tissue of Alzheimer's disease (AD), progressive supranuclear palsy, amyotrophic lateral sclerosis, Pick's disease, and controls. In controls, only capillaries were stained for ICAM-1. In affected areas of neurologically diseased brains, a subset of reactive astrocytes was also strongly stained. In addition, there were irregular, diffuse patches of positive staining in the tissue matrix. In AD, many of these patches had dense cores which corresponded with senile plaques. Double immunostaining for glial fibrillary acidic protein and ICAM-1 indicated that some reactive astrocytes at the periphery of senile plaques were positive for ICAM-1. Within such plaques, microglial aggregates were stained intensely for leukocyte function-associated antigen-1 (LFA-1), the adhesion molecule for ICAM-1. The LFA-1/ICAM-1 system appears to play an important role in the interaction of astrocytes and microglia in several neurological diseases.
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In postmortem tissue from patients with AD, increased expression of ICAM-1 has been detected in plaques and astrocytes around plaques.
“In postmortem tissue from patients with AD, increased expression of ICAM-1 has been detected in plaques and astrocytes around plaques.28”
From CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease (2018) · cites this paper as [28]
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- Authors
- Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L.
- Affiliations
- University of British Columbia (CA)
- Tokyo Institute of Psychiatry (JP)
- Venue
- Acta Neuropathologica
- Published
- 1993-05
- Volume
- 85
- Issue
- 6
- Pages
- 628-634
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W1975822780
- Cited by
- 137
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- ICAM-1, reactive astrocytes, Alzheimer's disease, amyloid plaques, LFA-1, microglia, astrocyte-microglia interaction, progressive supranuclear palsy, amyotrophic lateral sclerosis, Pick's disease, degenerative neurological disorders, glial fibrillary acidic protein
- MeSH terms
- Alzheimer Disease, Amyotrophic Lateral Sclerosis, Astrocytes, Brain, Brain Chemistry, Dementia, Endothelium, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, Nervous System Diseases, Neuroglia, Supranuclear Palsy, Progressive, Cell Adhesion Molecules, Lymphocyte Function-Associated Antigen-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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