Cited by 147Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsCell Adhesion Molecules Research

Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

Akiyama, Haruhiko, Kawamata, Toshio, Yamada, Tatsuo, Tooyama, Ikuo, Ishii, Tsyoshi, McGeer, Patrick L.·1993·Acta Neuropathologica

Abstract

Intercellular adhesion molecule-1 (ICAM-1) was localized immunohistochemically in postmortem brain tissue of Alzheimer's disease (AD), progressive supranuclear palsy, amyotrophic lateral sclerosis, Pick's disease, and controls. In controls, only capillaries were stained for ICAM-1. In affected areas of neurologically diseased brains, a subset of reactive astrocytes was also strongly stained. In addition, there were irregular, diffuse patches of positive staining in the tissue matrix. In AD, many of these patches had dense cores which corresponded with senile plaques. Double immunostaining for glial fibrillary acidic protein and ICAM-1 indicated that some reactive astrocytes at the periphery of senile plaques were positive for ICAM-1. Within such plaques, microglial aggregates were stained intensely for leukocyte function-associated antigen-1 (LFA-1), the adhesion molecule for ICAM-1. The LFA-1/ICAM-1 system appears to play an important role in the interaction of astrocytes and microglia in several neurological diseases.

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Crossref · 10.1007/bf00334673

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Authors
Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L.
Affiliations
  • University of British Columbia (CA)
  • Tokyo Institute of Psychiatry (JP)
Venue
Acta Neuropathologica
Published
1993-05
Volume
85
Issue
6
Pages
628-634
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
OpenAlex
W1975822780
Cited by
137
References
30
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 6 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
3.05
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
ICAM-1, reactive astrocytes, Alzheimer's disease, amyloid plaques, LFA-1, microglia, astrocyte-microglia interaction, progressive supranuclear palsy, amyotrophic lateral sclerosis, Pick's disease, degenerative neurological disorders, glial fibrillary acidic protein
MeSH terms
Alzheimer Disease, Amyotrophic Lateral Sclerosis, Astrocytes, Brain, Brain Chemistry, Dementia, Endothelium, Glial Fibrillary Acidic Protein, Humans, Immunohistochemistry, Nervous System Diseases, Neuroglia, Supranuclear Palsy, Progressive, Cell Adhesion Molecules, Lymphocyte Function-Associated Antigen-1

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