IL-2 and IL-6 secretion in dementia: correlation with type and severity of disease
Abstract
The production of interleukin-2 (IL-2) and interleukin-6 (IL-6) by peripheral blood mononuclear cells (MNC) was assessed in patients with Alzheimer's disease (AD) who were subdivided into two groups--mild and moderately-severe--according to the severity of the disease, probable vascular dementia (VaD) patients and elderly control subjects. No differences in IL-2 secretion were found between mild AD patients and controls. However, there was a significant increase in IL-2 production both in the moderately-severe AD group and in the VaD group. IL-6 levels in AD patients of both groups were similar and significantly higher than those of VaD and controls. Our results suggest that increased levels of IL-2-production correlate with severity of the dementia, whereas increased levels of IL-6 production seem to be related to AD and thus may play a role in AD pathogenesis.
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There is some evidence of elevated IL-6 levels in monocytes derived from AD patients.
“In fact, there is some evidence of elevated IL-6 levels in monocytes derived from AD patients [154–156].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [154]
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- Authors
- Huberman, M., Sredni, B., Stern, L., Kott, E., & Shalit, F.
- Affiliations
- Bar-Ilan University (IL)
- Meir Medical Center (IL)
- Corresponding author
- Huberman, M.
- ORCID
- Sredni, B.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 130
- Issue
- 2
- Pages
- 161-164
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2039132151
- Cited by
- 62
- References
- 1
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2017: 1 · 2015: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- interleukin-2, interleukin-6, Alzheimer's disease, vascular dementia, dementia severity, peripheral blood mononuclear cells, cytokine production, dementia pathogenesis
- MeSH terms
- Aged, Alzheimer Disease, Dementia, Enzyme-Linked Immunosorbent Assay, Female, Humans, Interleukin-2, Male, Psychiatric Status Rating Scales, Dementia, Multi-Infarct, Interleukin-6
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