Cited by 46Fatty Acid Research and HealthStress Responses and CortisolMemory and Neural Mechanisms

Fatty acid mixture counters stress changes in cortisol, cholesterol, and impair learning

Yehuda, S., Rabinovitz, S., Carasso, R. L., Mostofsky, D. I.·2000·International Journal of Neuroscience

Abstract

A mixture of linoleic and alpha-linolenic acids (free non-esterified unsaturated fatty acids) administered for 3 weeks prior to injection of cortisol (10 mg/kg), or prior to immersion of rats in a 10 degree C saline bath, prevented elevation of blood levels of cortisol and cholesterol and deficits in Morris water maze spatial learning that usually accompany such stressful conditions. Differences from controls on all behavioural and biochemical measures were statistically significant (P < .05). It is proposed that induction of intense stress, and the associated increase in cortisol, cholesterol and other corticosteroids may damage hippocampal structures and help account for the cognitive decline witnessed in Alzheimer's disease and other age-related conditions. The modulation of these consequences by the fatty acid mixture may provide an alternative strategy for the study of stress markers and for the development of other intervention options in humans.

Integrity signals

Registry

Crossref · 10.3109/00207450008986494

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66 of 66 references verified0 citation errors · 0 not checkable

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  • ω-3 fatty acids have benefits for central functioning ranging from enhanced memory, mood, attention, and cognitive performance to a reduced risk of developing depression and regulation of stress sensitivity.

    “The benefits of ω-3 (n-3) fatty acids for central functioning range from enhanced memory, mood, attention, and cognitive performance to a reduced risk of developing depression and regulation of stress sensitivity (131-138).”

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Authors
Yehuda, S., Rabinovitz, S., Carasso, R. L., & Mostofsky, D. I.
Affiliations
  • Bar-Ilan University (IL)
  • Hillel Yaffe Medical Center (IL)
  • Boston University (US)
Corresponding author
Yehuda, S.
Venue
International Journal of Neuroscience
Published
2000-01
Volume
101
Issue
1-4
Pages
73-87
ISSN
  • 0020-7454 (ISSN-L)
  • 1543-5245
OpenAlex
W2038750407
Cited by
46
References
65
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 4 · 2019: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3
FWCI
1.99
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
linoleic acid, alpha-linolenic acid, unsaturated fatty acids, dietary fatty acid supplementation, stress, cortisol, cholesterol, spatial learning, hippocampus, cognitive decline, Alzheimer's disease, cold stress, Morris water maze
MeSH terms
Animals, Cholesterol, Hippocampus, Hydrocortisone, Male, Stress, Psychological, Rats, Sprague-Dawley, alpha-Linolenic Acid, Maze Learning, Linoleic Acid, Rats

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