Fatty acid mixture counters stress changes in cortisol, cholesterol, and impair learning
Abstract
A mixture of linoleic and alpha-linolenic acids (free non-esterified unsaturated fatty acids) administered for 3 weeks prior to injection of cortisol (10 mg/kg), or prior to immersion of rats in a 10 degree C saline bath, prevented elevation of blood levels of cortisol and cholesterol and deficits in Morris water maze spatial learning that usually accompany such stressful conditions. Differences from controls on all behavioural and biochemical measures were statistically significant (P < .05). It is proposed that induction of intense stress, and the associated increase in cortisol, cholesterol and other corticosteroids may damage hippocampal structures and help account for the cognitive decline witnessed in Alzheimer's disease and other age-related conditions. The modulation of these consequences by the fatty acid mixture may provide an alternative strategy for the study of stress markers and for the development of other intervention options in humans.
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ω-3 fatty acids have benefits for central functioning ranging from enhanced memory, mood, attention, and cognitive performance to a reduced risk of developing depression and regulation of stress sensitivity.
“The benefits of ω-3 (n-3) fatty acids for central functioning range from enhanced memory, mood, attention, and cognitive performance to a reduced risk of developing depression and regulation of stress sensitivity (131-138).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [135]
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Depression and Stress, Role of n-3 and n-6 Fatty Acids
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Mediterranean Diet for Active and Healthy Aging
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Chronic stress alters serum lipids: effects due to "stress eating" versus metabolic changes
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Bourre, J. M. (2005)
0010 The Diurnal Rhythmicity of Untargeted Metabolomic Profiles in Humans
Nagarajan, P., Faquih, T. O., Yu, B., Dashti, H. S., Noordam, R., Xiao, Q., Kaplan, R. C., Qi, Q., Isasi, C. R., Saxena, R., et al. (2025) · SLEEP · doi:10.1093/sleep/zsaf090.0010
Flaxseed Administration Improves Affective and Cognitive Functions in Fructose Diet Wistar Rats
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- Authors
- Yehuda, S., Rabinovitz, S., Carasso, R. L., & Mostofsky, D. I.
- Affiliations
- Bar-Ilan University (IL)
- Hillel Yaffe Medical Center (IL)
- Boston University (US)
- Corresponding author
- Yehuda, S.
- Venue
- International Journal of Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 101
- Issue
- 1-4
- Pages
- 73-87
- ISSN
- 0020-7454 (ISSN-L)
- 1543-5245
- OpenAlex
- W2038750407
- Semantic Scholar
- e392a28d8f0a3164fdb26e546598c51a2f8c3241
- Cited by
- 46
- References
- 65
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 4 · 2019: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- linoleic acid, alpha-linolenic acid, unsaturated fatty acids, dietary fatty acid supplementation, stress, cortisol, cholesterol, spatial learning, hippocampus, cognitive decline, Alzheimer's disease, cold stress, Morris water maze
- MeSH terms
- Animals, Cholesterol, Hippocampus, Hydrocortisone, Male, Stress, Psychological, Rats, Sprague-Dawley, alpha-Linolenic Acid, Maze Learning, Linoleic Acid, Rats
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