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Cited by 75Rheumatoid Arthritis Research and TherapiesAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

Impaired glucose handling in active rheumatoid arthritis: Relationship to the secretion of insulin and counter-regulatory hormones

Svenson, Karin L.G., Lundqvist, Gudmar, Wide, Leif, Hällgren, Roger·1987·Metabolism
DOI 10.1016/0026-0495(87)90128-4
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Abstract

An intravenous glucose tolerance test was performed in 45 untreated patients with active inflammatory rheumatoid arthritis and in age- and sex-matched healthy subjects. The mean k value in the patients, which correlated to the inflammatory activity, was 1.0 +/- 0.05 (SEM), which was significantly lower (P less than .001) than in the controls (1.8 +/- 0.09). The basal serum insulin concentration and the maximum insulin response to glucose loading were significantly higher (P less than .001 and P less than .01, respectively) in the patient group. The patients had a normal basal concentration of growth hormone in the serum, but during glucose infusion the concentration increased. The plasma glucagon level was significantly lower than in the controls (P less than .001). The urinary output of cortisol and catecholamines was normal. It is concluded that impaired glucose handling in active chronic inflammatory disease cannot be explained as a stress reaction but may be due to peripheral insulin resistance mediated by the inflammatory process. A paradoxical increase in growth hormone secretion during glucose infusion may suggest that this hormone is one factor that influences glucose handling in chronic inflammation. The pathophysiologic relevance of altered glucose metabolism and enhanced insulin secretion is uncertain but may reflect a possible link with the proposedly increased risk of atherosclerotic cardiovascular disease in rheumatoid arthritis.

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Authors
Svenson, K. L. G., Lundqvist, G., Wide, L., & Hällgren, R.
Affiliations
Uppsala University Hospital (SE)
Corresponding author
Svenson, Karin L.G.
ORCID
Wide, Leif
Venue
Metabolism
Publisher
Elsevier BV
Published
1987-10
Volume
36
Issue
10
Pages
940-943
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(87)90128-4
OpenAlex
W1993916561
Cited by
75
References
48
Citations by year
2025: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 6
FWCI
1.98
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
rheumatoid arthritis, glucose tolerance, insulin secretion, insulin resistance, growth hormone, glucagon, counterregulatory hormones, chronic inflammation, glucose metabolism, atherosclerotic cardiovascular disease risk
MeSH terms
Insulin Secretion, Adolescent, Adult, Aged, Arthritis, Rheumatoid, Blood Glucose, Female, Glucagon, Glucose Tolerance Test, Humans, Inflammation, Insulin, Male, Metabolic Clearance Rate, Middle Aged, Growth Hormone, Stress, Physiological

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