CoChat
Sign Up
Cited by 226Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsSperm and Testicular Function

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men.

Haffner, Steven M., Valdez, Rodolfo A., Mykkänen, Leena, Stern, Michael P., Katz, Michael S.·1994·Metabolism
DOI 10.1016/0026-0495(94)90202-x
Open this paper in CoChat — free account

Abstract

Although many studies indicate that increased androgenicity is associated with insulin resistance and hyperinsulinemia in both premenopausal and postmenopausal women, relatively few data are available on this relationship in men. We examined the association of sex hormone-binding globulin (SHBG), total and free testosterone, dehydroepiandrosterone sulfate (DHEA-SO4), and estradiol to glucose and insulin concentrations before and during an oral glucose tolerance test in 178 men from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Total and free testosterone and DHEA-SO4 were significantly inversely associated with insulin concentrations. Free testosterone and DHEA-SO4 were also significantly inversely correlated with glucose concentrations. SHBG was weakly positively associated with glucose concentrations. Estradiol was not related to glucose or insulin concentrations. After adjustment for age, obesity, and body fat distribution, insulin concentrations remained significantly inversely correlated with free testosterone (r = -.23), total testosterone (r = -.21), and DHEA-SO4 (r = -.21; all P < .01). In conclusion, we observed that increased testosterone and DHEA-SO4 are associated with lower insulin concentrations in men. This is in striking contrast to women, where increased androgenicity is associated with insulin resistance and hyperinsulinemia.

Overview

Integrity signals

Registry

Crossref · 10.1016/0026-0495(94)90202-x

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 38 references

Research works printed but not linked: 1

  1. World Health Organization Expert Committee, 1980, Second report on diabetes mellitus, WHO Tech Rep Ser No. 646

Cited by

Sorted by citations

Items 201–223 of 223

Related

See all

Metadata

Authors
Haffner, S. M., Valdez, R. A., Mykkänen, L., Stern, M. P., & Katz, M. S.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Katz, Michael S.
ORCID
Valdez, Rodolfo A.
Venue
Metabolism
Publisher
Elsevier BV
Published
1994-05
Volume
43
Issue
5
Pages
599-603
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(94)90202-x
OpenAlex
W2016392921
Cited by
226
References
38
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 7
FWCI
6.44
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r37hl036820-10)
  • National Heart, Lung, and Blood Institute (R37HL36820, R01HL024799, R01HL24799)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
testosterone, dehydroepiandrosterone sulfate, insulin, insulin resistance, hyperinsulinemia, sex hormone-binding globulin, estradiol, oral glucose tolerance test, glucose, men, androgens, San Antonio Heart Study
MeSH terms
Adult, Aging, Anthropometry, Blood Glucose, Dehydroepiandrosterone, Female, Humans, Insulin, Male, Middle Aged, Osmolar Concentration, Reference Values, Regression Analysis, Sex Characteristics, Sex Hormone-Binding Globulin, Testosterone, Dehydroepiandrosterone Sulfate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review