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Cited by 226Hormonal and reproductive studiesDiabetes, Cardiovascular Risks, and LipoproteinsSperm and Testicular Function

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men.

Haffner, Steven M., Valdez, Rodolfo A., Mykkänen, Leena, Stern, Michael P., Katz, Michael S.·1994·Metabolism
DOI 10.1016/0026-0495(94)90202-x
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Abstract

Although many studies indicate that increased androgenicity is associated with insulin resistance and hyperinsulinemia in both premenopausal and postmenopausal women, relatively few data are available on this relationship in men. We examined the association of sex hormone-binding globulin (SHBG), total and free testosterone, dehydroepiandrosterone sulfate (DHEA-SO4), and estradiol to glucose and insulin concentrations before and during an oral glucose tolerance test in 178 men from the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Total and free testosterone and DHEA-SO4 were significantly inversely associated with insulin concentrations. Free testosterone and DHEA-SO4 were also significantly inversely correlated with glucose concentrations. SHBG was weakly positively associated with glucose concentrations. Estradiol was not related to glucose or insulin concentrations. After adjustment for age, obesity, and body fat distribution, insulin concentrations remained significantly inversely correlated with free testosterone (r = -.23), total testosterone (r = -.21), and DHEA-SO4 (r = -.21; all P < .01). In conclusion, we observed that increased testosterone and DHEA-SO4 are associated with lower insulin concentrations in men. This is in striking contrast to women, where increased androgenicity is associated with insulin resistance and hyperinsulinemia.

Overview

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Crossref · 10.1016/0026-0495(94)90202-x

Cites

40 of 40 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. World Health Organization Expert Committee, 1980, Second report on diabetes mellitus, WHO Tech Rep Ser No. 646

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Metadata

Authors
Haffner, S. M., Valdez, R. A., Mykkänen, L., Stern, M. P., & Katz, M. S.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Katz, Michael S.
ORCID
Valdez, Rodolfo A.
Venue
Metabolism
Publisher
Elsevier BV
Published
1994-05
Volume
43
Issue
5
Pages
599-603
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(94)90202-x
OpenAlex
W2016392921
Cited by
226
References
38
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 7
FWCI
6.44
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r37hl036820-10)
  • National Heart, Lung, and Blood Institute (R37HL36820, R01HL024799, R01HL24799)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
testosterone, dehydroepiandrosterone sulfate, insulin, insulin resistance, hyperinsulinemia, sex hormone-binding globulin, estradiol, oral glucose tolerance test, glucose, men, androgens, San Antonio Heart Study
MeSH terms
Adult, Aging, Anthropometry, Blood Glucose, Dehydroepiandrosterone, Female, Humans, Insulin, Male, Middle Aged, Osmolar Concentration, Reference Values, Regression Analysis, Sex Characteristics, Sex Hormone-Binding Globulin, Testosterone, Dehydroepiandrosterone Sulfate

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