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Cited by 106Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsCholesterol and Lipid Metabolism

The effects of weight loss by exercise or by dieting on plasma high-density lipoprotein (HDL) levels in men with low, intermediate, and normal-to-high HDL at baseline

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Williams, Paul T., Stefanick, Marcia L., Vranizan, Karen M., Wood, Peter D.·1994·Metabolism
DOI 10.1016/0026-0495(94)90277-1PMC PMC2864614
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Abstract

To assess whether baseline plasma high-density lipoprotein (HDL) cholesterol levels affected the HDL response to weight loss, we examined lipoprotein changes in overweight men aged 30 to 59 years who were randomized to lose weight by exercise training (primarily running, n = 46) or by caloric restriction (ie, dieting, n = 42) or to remain sedentary, nondieting controls (n = 42) in a 1-year study. In exercisers, absolute increases in HDL (mg/dL) were greatest in men with normal-to-high baseline HDL and least in men with low baseline HDL. Specifically, when divided into groups of low (< or = 37 mg/dL), intermediate (38 to 47 mg/dL), and normal-to-high HDL cholesterol (> or = 48 mg/dL) at baseline, the exercisers increased HDL cholesterol by 2.3 +/- 1.9, 4.9 +/- 1.1, and 7.0 +/- 1.3 mg/dL, respectively; HDL2 cholesterol by 0.8 +/- 1.6, 2.3 +/- 1.2, and 5.1 +/- 1.3 mg/dL; and HDL2 mass by 2.8 +/- 5.1, 9.5 +/- 8.9, and 31.7 +/- 11.0 mg/dL. Relative increases in HDL cholesterol were more similar in the low (7.1% +/- 6.1%), intermediate (12.4% +/- 3.9%), and normal-to-high men (13.2% +/- 4.0%). Regression analyses were performed to assess whether baseline HDL cholesterol was related to the amount of absolute HDL change per unit of weight loss. In exercisers, the increase in HDL3 cholesterol concentrations was significantly greater in men with low HDL than in those with normal-to-high HDL at entry (2.0 +/- 0.8 v 0.2 +/- 0.8 mg/dL per kg/m2 lost).(ABSTRACT TRUNCATED AT 250 WORDS)

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  1. [8]Warnick GR, Benderson J, Alhers JJ. Quantitation of high-density-lipoprotein subclasses after separation by dextran sulfate and Mg2+ precipitation. Clin Chem. 1982;28:1574. abstr. [PubMed] [Google Scholar]
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Authors
Williams, P. T., Stefanick, M. L., Vranizan, K. M., & Wood, P. D.
Affiliations
Lawrence Berkeley National Laboratory (US)
Corresponding author
Williams, Paul T.
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
1994-07
Volume
43
Issue
7
Pages
917-924
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(94)90277-1
PMC
PMC2864614
OpenAlex
W2019784051
Cited by
106
References
29
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 8 · 2019: 1 · 2018: 1 · 2017: 2 · 2015: 7 · 2014: 6 · 2013: 4 · 2012: 2
FWCI
1.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5k04hl002183-05, 1r03hl049828-01a1, 5r01hl024462-10)
  • National Institute on Aging (R03AG032004)
  • National Heart, Lung, and Blood Institute (HL-49828, HL-24462, HL-02183)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
HDL cholesterol, weight loss, exercise training, caloric restriction, dieting, overweight men, running, lipoprotein metabolism
MeSH terms
Adult, Diet, Reducing, Humans, Lipoproteins, HDL, Cholesterol, HDL, Male, Middle Aged, Reference Values, Weight Loss, Exercise

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