Maternal and perinatal outcome in thyrotoxicosis complicating pregnancy
Abstract
In this report we describe 32 pregnancies complicated by hyperthyroidism cared for over a 7-year period at AIIMS, New Delhi. In 6 cases hyperthyroidism was diagnosed during pregnancy; others were diagnosed before conception and were on antithyroid therapy during pregnancy. For control of thyrotoxicosis thiourea derivatives, carbimazole (CMZ) and propylthiouracil (PTU), were both used. The dosage of antithyroid drugs could be decreased or stopped in the third trimester in only 28% cases, while 50% cases did not require any change in the dosage during gestation and 21% required an increase in dosage with advancing gestation to control thyrotoxicosis. Maternal and fetal complications included preterm labour (25%), PIH (22%), thyroid crisis (9%) and intrauterine growth retardation (13%). Thyroid status of neonates was found abnormal in 9% cases, including 1 case (3%) of neonatal thyrotoxicosis with goitre and 2 (6%) cases of neonatal hypothyroidism. One maternal death occurred due to thyroid storm. No case of stillbirth or perinatal death occurred in the present study. In our experience of 32 cases maternal and fetal complications are reported with increased frequency, requiring close surveillance of thyroid status to maintain euthyroidism and intensive fetal monitoring during pregnancy to achieve good maternal and perinatal outcome.
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Untreated or insufficiently treated hyperthyroidism may seriously complicate pregnancy.
“Untreated or insufficiently treated hyperthyroidism may seriously complicate pregnancy (452-454), and patients with this disorder should be treated at centers with specific expertise in this area.”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [454]
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Katulanda, P. (2012) · Sri Lanka Journal of Obstetrics and Gynaecology · doi:10.4038/sljog.v32i2.3977
Perinatal outcome of pregnancy with hyperthyroidism
Ko, H. S., Jang, D. G., Shin, J. E., Kim, Y. H., Park, I. Y., & Shin, J. C. (2010) · Korean Journal of Obstetrics & Gynecology · doi:10.5468/kjog.2010.53.9.795
For information on reprint requests of more than 101 and commercial reprints contact
Barbour, L. A., Cobin, R. H., DeGroot, L. J., Glinoer, D., Mandel, S. J., & Edwards, H. A. (2008)
Sibai, B. M., & Bombrys, A. E. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6270-7.00013-2
Congestive cardiac failure as a presentation of neonatal Graves in twin
Ray, S., Mondal, R. K., Sabui, T. K., & Biswas, R. (2017) · Eastern Journal Of Medicine · doi:10.5505/ejm.2017.57441
Other causes of potential maternal collapse
Aras-Payne, A. (2017) · Routledge eBooks · doi:10.1201/9781315380216-19
Rajoriya, M., & Singh, D. (2020) · International Journal of Clinical Obstetrics and Gynaecology · doi:10.33545/gynae.2020.v4.i3b.581
Winkler, C. L., & Davis, L. E. (2004) · doi:10.1002/9780470760086.ch32
Maternal disorders and stillbirth
Dekker, G. (2010) · Series in maternal-fetal medicine · doi:10.3109/9781841847191.003
Winkler, C. L., & Coleman, F. (2010) · doi:10.1002/9781444316780.ch33
- Authors
- Kriplani, A., Buckshee, K., Bhargava, V. L., Takkar, D., & Ammini, A. C.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 1994-05
- Volume
- 54
- Issue
- 3
- Pages
- 159-163
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W1969160789
- Cited by
- 104
- References
- 17
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- thyrotoxicosis, hyperthyroidism in pregnancy, antithyroid drugs, carbimazole, propylthiouracil, thiourea derivatives, thyroid storm, preterm labour, preeclampsia, fetal growth restriction, neonatal hypothyroidism, neonatal thyrotoxicosis, maternal mortality, fetal monitoring
- MeSH terms
- Adult, Female, Humans, Hyperthyroidism, Infant, Newborn, Obstetric Labor, Premature, Lactation, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Antithyroid Agents, Thyroid Function Tests, Thyrotoxicosis, Treatment Outcome
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