CoChat
Sign Up
Cited by 220Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Modelling dementia: Effects of scopolamine on memory and attention

Broks, P., Preston, G.C., Traub, M., Poppleton, P., Ward, C., Stahl, S.M.·1988·Neuropsychologia
DOI 10.1016/0028-3932(88)90004-8
Open this paper in CoChat — free account

Abstract

Scopolamine, a muscarinic cholinergic antagonist, is capable of inducing transient memory impairment in normal subjects. Against the background of the cholinergic hypothesis of Alzheimer's disease (AD) the present study was designed to investigate the effects of low oral doses of scopolamine on a range of cognitive functions known or hypothesized to be affected in AD. Twenty healthy volunteers (18-48 yr) performed a battery of automated cognitive tasks under each of five treatments: oral scopolamine 0.3 mg, 0.6 mg, 1.2 mg; oral methylscopolamine 0.6 mg; placebo. Alongside analogous tests of verbal and non-verbal memory, the battery enabled assessments of a range of attentional functions: alerting, sustained attention, selective attention, and covert orientation. A profile of effects was observed within and beyond the realm of memory. While some functions were unaffected by the drug (e.g. alerting) and others were impaired at the highest dose (e.g. verbal learning) still others were affected in a linear dose-dependent manner (sustained attention; visual contrast sensitivity). These observations are discussed in the context of the "scopolamine model" of AD.

Integrity signals

Registry

Crossref · 10.1016/0028-3932(88)90004-8

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The degree to which acute mAChR blockade models such dementias seems rather impressive.

    “In light of these considerations, the degree to which acute mAChR blockade models such dementias seems rather impressive (see also Christensen et al, 1992; Aarsland et al, 1994; Broks et al, 1988).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Broks et al, 1988

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Broks, P., Preston, G. C., Traub, M., Poppleton, P., Ward, C., & Stahl, S. M.
Affiliations
MSD (UK) Limited (United Kingdom) (GB)
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
1988
Volume
26
Issue
5
Pages
685-700
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/0028-3932(88)90004-8
OpenAlex
W2079533377
Cited by
220
References
48
Citations by year
2026: 2 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
9.33
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
scopolamine, memory impairment, attention, sustained attention, selective attention, alerting, contrast sensitivity, verbal learning, dose-dependent effects, methylscopolamine, cognitive function
MeSH terms
Adolescent, Adult, Attention, Brain, Dementia, Female, Humans, Male, Memory, Middle Aged, Models, Biological, Neuropsychological Tests, Orientation, Reaction Time, Mental Recall, Receptors, Cholinergic, Scopolamine, Scopolamine Derivatives, N-Methylscopolamine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review