Cited by 75Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Leveraging the cortical cholinergic system to enhance attention

Open access
Demeter, Elise, Sarter, Martin·2013·Neuropharmacology

Abstract

Attentional impairments are found in a range of neurodegenerative and neuropsychiatric disorders. However, the development of procognitive enhancers to alleviate these impairments has been hindered by a lack of comprehensive hypotheses regarding the circuitry mediating the targeted attentional functions. Here we discuss the role of the cortical cholinergic system in mediating cue detection and attentional control and propose two target mechanisms for cognition enhancers: stimulation of prefrontal α4β2* nicotinic acetylcholine receptors (nAChR) for the enhancement of cue detection and augmentation of tonic acetylcholine levels for the enhancement of attentional control. This article is part of a Special Issue entitled 'Cognitive Enhancers'.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2012.06.060

Cites

173 of 173 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Demeter, E., & Sarter, M.
Affiliations
University of Michigan (US)
Corresponding author
Demeter, Elise
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2013-01
Volume
64
Pages
294-304
ISSN
0028-3908 (ISSN-L)
OpenAlex
W1971280731
Cited by
75
References
173
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 8 · 2012: 2
FWCI
0.88
Type
journal article
Language
en
Open access
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH057436, R01MH086530)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
attention, nootropic drugs, nicotinic acetylcholine receptors, alpha4beta2 nAChR, prefrontal cortex, cue detection, attentional control, attentional impairment, neurodegenerative diseases
MeSH terms
Animals, Attention, Cholinesterase Inhibitors, Cognition Disorders, Humans, Nerve Tissue Proteins, Prefrontal Cortex, Nootropic Agents, Muscarinic Agonists, Nicotinic Agonists, Performance-Enhancing Substances, Molecular Targeted Therapy, Cholinergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review