Leveraging the cortical cholinergic system to enhance attention
Open accessAbstract
Attentional impairments are found in a range of neurodegenerative and neuropsychiatric disorders. However, the development of procognitive enhancers to alleviate these impairments has been hindered by a lack of comprehensive hypotheses regarding the circuitry mediating the targeted attentional functions. Here we discuss the role of the cortical cholinergic system in mediating cue detection and attentional control and propose two target mechanisms for cognition enhancers: stimulation of prefrontal α4β2* nicotinic acetylcholine receptors (nAChR) for the enhancement of cue detection and augmentation of tonic acetylcholine levels for the enhancement of attentional control. This article is part of a Special Issue entitled 'Cognitive Enhancers'.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The nucleus basalis of Meynert and pedunculopontine tegmental nucleus are major sources of cholinergic input to the rest of the brain and important regulators of selective attention and motivation.
“These nuclei are major sources of cholinergic input to the rest of the brain (44-46) and are important regulators of selective attention and motivation (47-52).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [47]
The muscarinic acetylcholine system may work with the oxytocin system to boost attention.
“The muscarinic acetylcholine system may also work with the oxytocin system to boost attention62”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881 · see citing works
A feature-integration theory of attention.
Treisman, A. M., & Gelade, G. (1980) · Cognitive Psychology · doi:10.1016/0010-0285(80)90005-5 · Cited by 12,366 · see citing works
Attention and the detection of signals.
Posner, M. I., Snyder, C. R., & Davidson, B. J. (1980) · Journal of Experimental Psychology: General · doi:10.1037/0096-3445.109.2.160 · Cited by 3,778 · see citing works
Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598 · see citing works
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033430 · Cited by 2,999 · see citing works
Neurocognitive deficit in schizophrenia: A quantitative review of the evidence.
Heinrichs, R. W., & Zakzanis, K. K. (1998) · Neuropsychology · doi:10.1037/0894-4105.12.3.426 · Cited by 2,798 · see citing works
Neurocognitive deficit in schizophrenia: A quantitative review of the evidence.
Heinrichs, R. W., & Zakzanis, K. K. (1998) · Neuropsychology · doi:10.1037//0894-4105.12.3.426 · Cited by 2,791 · see citing works
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331 · see citing works
A default mode of brain function: a brief history of an evolving idea
Raichle, M. E., & Snyder, A. Z. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.041 · Cited by 2,173 · see citing works
Mechanisms of visual attention in the human cortex
Ungerleider, S. K. A. L. G. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.315 · Cited by 2,159 · see citing works
Function of the thalamic reticular complex: the searchlight hypothesis
Crick, F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4586 · Cited by 1,651 · see citing works
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
Rogers, S. L., Farlow, M. R., Doody, R. S., Mohs, R., Friedhoff, L. T., & Donepezil Study Group* (1998) · Neurology · doi:10.1212/wnl.50.1.136 · Cited by 1,618 · see citing works
International Union of Pharmacology. XVII. Classification of Muscarinic Acetylcholine Receptors
Caulfield, M. P., & Birdsall, N. J. M. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01362-0 · Cited by 1,474 · see citing works
Identification of separable cognitive factors in schizophrenia
Nuechterlein, K. H., Barch, D. M., Gold, J. M., Goldberg, T. E., Green, M. F., & Heaton, R. K. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.09.007 · Cited by 1,304 · see citing works
The cognitive neuroscience of sustained attention: where top-down meets bottom-up.
Sarter, M., Givens, B., & Bruno, J. P. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00044-3 · Cited by 1,194 · see citing works
Self-citationLevey, A. I., Kitt, C. A., Wf, S., Price, D., & Brann, M. R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03218.1991 · Cited by 920 · see citing works
Raskind (2000) · doi:10.1212/wnl.54.12.2261 · Cited by 870 · see citing works
Rogers, S. L., & Friedhoff, L. T. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106895 · Cited by 743 · see citing works
Modes and models of forebrain cholinergic neuromodulation of cognition
Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works
Self-citationAttention modulates responses in the human lateral geniculate nucleus
O’Connor, D. H., Fukui, M. M., Pinsk, M. A., & Kästner, S. (2002) · Nature Neuroscience · doi:10.1038/nn957 · Cited by 730 · see citing works
Sarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.006 · Cited by 667 · see citing works
Self-citationPrefrontal Acetylcholine Release Controls Cue Detection on Multiple Timescales
Parikh, V., Kozak, R., Martinez, V., & Sarter, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.025 · Cited by 623 · see citing works
Self-citationSelective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia
Shekhar, A., Potter, W. Z., Lightfoot, J., Lienemann, J., Dubé, S., Mallinckrodt, C. H., Bymaster, F. P., McKinzie, D. L., & Felder, C. C. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.06091591 · Cited by 563 · see citing works
More attention must be paid: The neurobiology of attentional effort
Sarter, M., Gehring, W. J., & Kozak, R. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.002 · Cited by 552 · see citing works
Self-citationSelective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
Anagnostaras, S., Murphy, G. G., Hamilton, S. E., Mitchell, S. L., Rahnama, N. P., Nathanson, N. M., & Silva, A. J. (2002) · Nature Neuroscience · doi:10.1038/nn992 · Cited by 543 · see citing works
Sahakian, B. J., Jones, G., Levy, R., Gray, J. A., & Warburton, D. M. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.6.797 · Cited by 494 · see citing works
Molecular Biology of Muscarinic Acetylcholine Receptors
Wess, J. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i1.40 · Cited by 491 · see citing works
Jones, G., Sahakian, B. J., Levy, R., Warburton, D. M., & Gray, J. A. (1992) · Psychopharmacology · doi:10.1007/bf02247426 · Cited by 476 · see citing works
Coordination of Voluntary and Stimulus-Driven Attentional Control in Human Cortex
Serences, J. T., Shomstein, S., Leber, A. B., Golay, X., Egeth, H. E., & Yantis, S. (2005) · Psychological Science · doi:10.1111/j.0956-7976.2005.00791.x · Cited by 470 · see citing works
Neuroimaging Studies of Attention: From Modulation of Sensory Processing to Top-Down Control
Pessoa, L., Kästner, S., & Ungerleider, L. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-03990.2003 · Cited by 452 · see citing works
McGaughy, J. A., Kaiser, T. E., & Sarter, M. F. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.2.247 · Cited by 435 · see citing works
Self-citationMcGaughy, J., Kaiser, T., & Sarter, M. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.247 · Cited by 435 · cited 6× · see citing works
“…model studies, selective lesions to the basal forebrain cortical cholinergic system in attention task-performing animals result in a severe and lasting impairment in signal detection, while the ability to correctly reject nonsignals remains intact (McGaughy et al., 1996; McGaughy & Sarter, 1998).”
BackgroundInfluentialSelf-citationInitial phase 2 trial of a nicotinic agonist in schizophrenia
Freedman, R., Olincy, A., Buchanan, R. W., Harris, J. G., Gold, J. M., Johnson, L., Allensworth, D., Guzman-Bonilla, A., Clement, B., Ball, M. P., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07071135 · Cited by 426 · see citing works
Muir, J. L., Everitt, B. J., & Robbins, T. W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02313.1994 · Cited by 421 · see citing works
M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice
Caccamo, A., Oddo, S., Billings, L. M., Green, K. N., Martinez-Coria, H., Fisher, A., & LaFerla, F. M. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.020 · Cited by 417 · see citing works
Nicotine effects on adults with attention-deficit/hyperactivity disorder
Levin, E. D., Conners, C. K., Sparrow, E., Hinton, S. C., Erhardt, D., Meck, W. H., Rose, J. E., & March, J. (1996) · Psychopharmacology · doi:10.1007/bf02246281 · Cited by 415 · see citing works
Functional contributions of α5 subunit to neuronal acetylcholine receptor channels
Ramírez-Latorre, J. A., Yu, C., Qu, X., Perin, F., Karlin, A., & Role, L. W. (1996) · Nature · doi:10.1038/380347a0 · Cited by 397 · see citing works
Miyakawa, T., Yamada, M., Duttaroy, A., & Wess, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05239.2001 · Cited by 366 · see citing works
Effects of scopolamine and nicotine on human rapid information processing performance
Wesnes, K. A., & Warburton, D. M. (1984) · Psychopharmacology · doi:10.1007/bf00427761 · Cited by 354 · see citing works
Cholinergic Hyperactivity and Negative Schizophrenic Symptoms
Tandon, R. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810080075010 · Cited by 354 · see citing works
Nicotinic receptor subtypes and cognitive function
Levin, E. D. (2002) · Journal of Neurobiology · doi:10.1002/neu.10151 · Cited by 354 · see citing works
McGaughy, J. A., & Sarter, M. F. (1995) · Psychopharmacology · doi:10.1007/bf02246109 · Cited by 348 · see citing works
Self-citationZikopoulos, B., & Barbas, H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5511-05.2006 · Cited by 344 · see citing works
Cognitive Mechanisms of Nicotine on Visual Attention
Lawrence, N., Ross, T. J., & Stein, E. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)01004-8 · Cited by 321 · see citing works
Robbins, T. W., Everitt, B. J., Marston, H. M., Wilkinson, J., Jones, G. H., & Page, K. J. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80143-3 · Cited by 321 · see citing works
Cholinergic Enhancement and Increased Selectivity of Perceptual Processing During Working Memory
Furey, M. L., Pietrini, P., & Haxby, J. V. (2000) · Science · doi:10.1126/science.290.5500.2315 · Cited by 308 · see citing works
Anticholinergic Sensitivity in Patients With Dementia of the Alzheimer Type and Age-Matched Controls
Sunderland, T. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800170032006 · Cited by 298 · see citing works
Carter, C., & Barch, D. (2007) · Schizophrenia bulletin · doi:10.1093/schbul/sbm081 · Cited by 296 · see citing works
Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders
Conn, P. J., Jones, C. K., & Lindsley, C. W. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.12.002 · Cited by 286 · see citing works
Dalley, J. W., McGaughy, J., O'Connell, M. T., Cardinal, R. N., Levita, L., & Robbins, T. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04908.2001 · Cited by 277 · see citing works
Yamada, M., Lamping, K. G., Duttaroy, A., Zhang, W., Cui, Y., Bymaster, F. P., McKinzie, D. L., Felder, C. C., Deng, C., Faraci, F. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251542998 · Cited by 275 · see citing works
Effects of diazepam and scopolamine on storage, retrieval and organizational processes in memory
Ghoneim, M. M., & Mewaldt, S. P. (1975) · Psychopharmacology · doi:10.1007/bf00428903 · Cited by 271 · see citing works
Attentional modulation of thalamic reticular neurons
McAlonan, K., Cavanaugh, J., & Wurtz, R. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5602-05.2006 · Cited by 261 · see citing works
Increases in cortical acetylcholine release during sustained attention performance in rats
Himmelheber, A. M., Sarter, M., & Bruno, J. P. (2000) · Cognitive Brain Research · doi:10.1016/s0926-6410(00)00012-4 · Cited by 261 · see citing works
Self-citationResidual performance deficit in clinically remitted schizophrenics: A marker of schizophrenia?
Asarnow, R. F., & MacCrimmon, D. J. (1978) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.87.6.597 · Cited by 255 · see citing works
Beatty, W. W., Butters, N., & Janowsky, D. S. (1986) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(86)90772-7 · Cited by 249 · see citing works
Z�borszky, L., Heimer, L., Eckenstein, F. P., & Leranth, C. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902500303 · Cited by 249 · see citing works
The Basal Forebrain Corticopetal System Revisited
Záborszky, L., Pang, K. C. H., Somogyi, J., Nádasdy, Z., & Kalló, I. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09276.x · Cited by 242 · see citing works
Grottick, A. J., & Higgins, G. A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00305-3 · Cited by 240 · see citing works
Shirey-Rice, J. K., Brady, A. E., Jones, P. J., Davis, A. A., Bridges, T. M., Kennedy, J. P., Jadhav, S. B., Menon, U. N., Xiang, Z., Watson, M. L., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3930-09.2009 · Cited by 237 · see citing works
Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System
Felder, C. C., Bymaster, F. P., Ward, J. S., & DeLapp, N. W. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990607u · Cited by 235 · see citing works
Gill, T. M., Sarter, M., & Givens, B. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04745.2000 · Cited by 228 · see citing works
Self-citationSustained Attention in Remitted Schizophrenics
Wohlberg, G. W. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750340065011 · Cited by 226 · see citing works
Passetti, F., Dalley, J. W., O’Connell, M. T., Everitt, B. J., & Robbins, T. W. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00183.x · Cited by 223 · see citing works
Cortical input to the basal forebrain
Záborszky, L., Gaykema, R. P. A., Swanson, D. J., & Cullinan, W. E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00049-3 · Cited by 221 · see citing works
Modelling dementia: Effects of scopolamine on memory and attention
Broks, P., Preston, G. C., Traub, M., Poppleton, P., Ward, C., & Stahl, S. M. (1988) · Neuropsychologia · doi:10.1016/0028-3932(88)90004-8 · Cited by 220 · see citing works
Young, J. W., Finlayson, K., Spratt, C., Marston, H. M., Crawford, N., Kelly, J. S., & Sharkey, J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300393 · Cited by 219 · see citing works
Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD).
Conners, C. K., Levin, E. D., Sparrow, E. P., Hinton, S. C., Erhardt, D., Meck, W. H., Rose, J. E., & March, J. S. (1996) · PubMed · Cited by 218 · see citing works
Studies on human memory: The interactions of diazepam, scopolamine, and physostigmine
Ghoneim, M. M., & Mewaldt, S. P. (1977) · Psychopharmacology · doi:10.1007/bf00426592 · Cited by 215 · see citing works
Everitt, B. J., Robbins, T. W., & Muir, J. L. (1995) · Psychopharmacology · doi:10.1007/bf02245253 · Cited by 214 · see citing works
Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network
Hahn, B., Ross, T. J., Yang, Y., Kim, I., Huestis, M. A., & Stein, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5129-06.2007 · Cited by 199 · see citing works
Arnold, H. M., Burk, J. A., Hodgson, E. M., Sarter, M., & Bruno, J. P. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00292-0 · Cited by 195 · see citing works
Self-citationResidual performance deficit in clinically remitted schizophrenics: A marker of schizophrenia?
Asarnow, R. F., & MacCrimmon, D. J. (1978) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.87.6.597 · Cited by 192 · see citing works
Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention
Guillem, K., Bloem, B., Poorthuis, R. B., Loos, M., Smit, A. B., Maskos, U., Spijker, S., & Mansvelder, H. D. (2011) · Science · doi:10.1126/science.1207079 · Cited by 191 · see citing works
Psychophysiological Dysfunctions in the Developmental Course of Schizophrenic Disorders
Dawson, M. E., & Nuechterlein, K. H. (1984) · Schizophrenia Bulletin · doi:10.1093/schbul/10.2.204 · Cited by 189 · see citing works
Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model
Molchan, S. E., Martínez, R. A., Hill, J., Weingartner, H. J., Thompson, K., Vitiello, B., & Sunderland, T. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90017-g · Cited by 184 · see citing works
Thiel, C. M., Zilles, K., & Fink, G. R. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300633 · Cited by 182 · see citing works
Nicotine enhances sustained attention in the rat under specific task conditions
Mirza, N. R., & Stolerman, I. P. (1998) · Psychopharmacology · doi:10.1007/s002130050671 · Cited by 181 · see citing works
Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I
Sarter, M. F., Hagan, J. J., & Dudchenko, P. A. (1992) · Psychopharmacology · doi:10.1007/bf02245132 · Cited by 181 · see citing works
Self-citationBentley, P., Masud Husain, B., & Dolan, R. J. (2004) · Neuron · doi:10.1016/s0896-6273(04)00145-x · Cited by 179 · see citing works
Effect of nicotine on brain activation during performance of a working memory task
Monique Ernst, D., Matochik, J. A., Heishman, S. J., Horn, J. D. V., Jons, P. H., Henningfield, J. E., & London, E. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061369098 · Cited by 178 · see citing works
Layer-Specific Modulation of the Prefrontal Cortex by Nicotinic Acetylcholine Receptors
Poorthuis, R. B., Bloem, B., Schak, B., Wester, J., de Kock, C. P. J., & Mansvelder, H. D. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhr390 · Cited by 176 · see citing works
Carter, C. S., Barch, D. M., Buchanan, R. W., Bullmore, E. T., Krystal, J. H., Cohen, J. D., Geyer, M. A., Green, M. M., Nuechterlein, K. H., Robbins, T. W., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.020 · Cited by 174 · see citing works
Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging
Bentley, P., Driver, J., & Dolan, R. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.06.002 · Cited by 173 · see citing works
Cholinergic Mediation of Attention
Parikh, V., & Sarter, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.021 · Cited by 171 · see citing works
Self-citationGalantamine for the treatment of cognitive impairments in people with schizophrenia
Buchanan, R. W., Conley, R. R., Dickinson, D., Ball, M. P., Feldman, S., Gold, J. M., & McMahon, R. P. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050724 · Cited by 170 · see citing works
Turchi, J. N., & Sarter, M. F. (1997) · Cognitive Brain Research · doi:10.1016/s0926-6410(97)00027-x · Cited by 165 · see citing works
Self-citationWilens, T. E., & Decker, M. W. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.002 · Cited by 164 · see citing works
Jeon, J., Dencker, D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3843-09.2010 · Cited by 164 · see citing works
Giocomo, L. M., & Hasselmo, M. E. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0032-z · Cited by 161 · see citing works
Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans
Ellis, J. R., Ellis, K. A., Bartholomeusz, C. F., Harrison, B. J., Wesnes, K. A., Erskine, F. F., Vitetta, L., & Nathan, P. J. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005407 · Cited by 154 · see citing works
Corticogeniculate feedback and visual processing in the primate
Briggs, F., & Usrey, W. M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.193599 · Cited by 151 · see citing works
Howe, W. M., Ji, J., Parikh, V., Williams, S., Mocaër, E., Trocmé-Thibierge, C., & Sarter, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.9 · Cited by 150 · cited 3× · see citing works
“In awake animals performing the SAT, systemic injection of a α4β2* agonist also results in cholinergic transients with higher amplitudes and sharper, faster decay profiles than injections of nicotine, confirming the patterns seen in anesthetized animals (Howe et al., 2010).”
BackgroundMethodInfluentialEnhanced Control of Attention by Stimulating Mesolimbic-Corticopetal Cholinergic Circuitry
Peters, M. M. M. S., Demeter, E., Lustig, C., Bruno, J., & Sarter, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-11.2011 · Cited by 147 · see citing works
Self-citationMcGaughy, J., & Sarter, M. (1998) · Behavioral Neuroscience · doi:10.1037/0735-7044.112.6.1519 · Cited by 147 · see citing works
Self-citationMarlo, J. E., Niswender, C. M., Days, E., Bridges, T. M., Xiang, Y., Rodriguez, A. L., Shirey-Rice, J. K., Brady, A. E., Nalywajko, T., Luo, Q., et al. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.052886 · Cited by 146 · see citing works
The Nicotinic Acetylcholine Receptor 5 Subunit Plays a Key Role in Attention Circuitry and Accuracy
Bailey, C. D. C., De Biasi, M., Fletcher, P. J., & Lambe, E. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2258-10.2010 · Cited by 146 · see citing works
Keefe, R. S. E., Malhotra, A. K., Meltzer, H. Y., Kane, J. M., Buchanan, R. W., Murthy, A. K., Sovel, M., Li, C., & GOLDMAN, R. S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301499 · Cited by 146 · see citing works
́borsky, L. ́. ́. Z., & Cullinan, W. E. (1992) · Brain Research · doi:10.1016/0006-8993(92)90568-t · Cited by 146 · see citing works
Nicotinic treatment of Alzheimer’s disease
Newhouse, P. A., Potter, A., Kelton, M., & Corwin, J. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01069-6 · Cited by 146 · see citing works
Augmented Prefrontal Acetylcholine Release during Challenged Attentional Performance
Kozak, R., Bruno, J. P., & Sarter, M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi079 · Cited by 144 · see citing works
Self-citationMcGaughy, J. A., & Sarter, M. F. (1998) · Behavioral Neuroscience · doi:10.1037//0735-7044.112.6.1519 · Cited by 143 · see citing works
Self-citationCognitive Control in Adolescence: Neural Underpinnings and Relation to Self-Report Behaviors
Andrews-Hanna, J. R., Mackiewicz Seghete, K. L., Claus, E. D., Burgess, G. C., Ruzic, L., & Banich, M. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021598 · Cited by 141 · see citing works
Blondel, A., Sanger, D. J., & Moser, P. C. (2000) · Psychopharmacology · doi:10.1007/s002130000378 · Cited by 138 · see citing works
Attentional effects of nicotinic agonists in rats
Hahn, B., Sharples, C. G. V., Wonnacott, S., Shoaib, M., & Stolerman, I. P. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00099-6 · Cited by 135 · see citing works
Sunderland, T., Tariot, P. N., & NEWHOUSE, P. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91227-9 · Cited by 134 · see citing works
The time course of information-processing deficits in schizophrenia
BRAFF, D. L., & Saccuzzo, D. P. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.2.170 · Cited by 134 · see citing works
Parikh, V., Ji, J., Decker, M. W., & Sarter, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5712-09.2010 · Cited by 133 · see citing works
Self-citationEffects of cholinergic depletion on neuron activities in the cat visual cortex
Sato, H., Hata, Y., Hagihara, K., & Tsumoto, T. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.58.4.781 · Cited by 133 · see citing works
Bushnell, P. J., Oshiro, W. M., & Padnos, B. K. (1997) · Psychopharmacology · doi:10.1007/s002130050446 · Cited by 131 · see citing works
Treating schizophrenia symptoms with an α7 nicotinic agonist, from mice to men
D, A. O. M., & Stevens, K. E. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.015 · Cited by 131 · see citing works
A low dose of subcutaneous nicotine improves information processing in non-smokers
Houezec, J. L., Halliday, R. A., Benowitz, N. L., Callaway, E., Naylor, H., & Herzig, K. E. (1994) · Psychopharmacology · doi:10.1007/bf02244994 · Cited by 130 · see citing works
Chapter 28 The modular organization of brain systems. Basal forebrain: the last frontier
Záborszky, L. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36030-8 · Cited by 129 · see citing works
Prefrontal cortical modulation of acetylcholine release in posterior parietal cortex
Nelson, C. L., Sarter, M., & Bruno, J. P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.007 · Cited by 128 · see citing works
Self-citationMcGaughy, J., Decker, M. W., & Sarter, M. (1999) · Psychopharmacology · doi:10.1007/s002130050991 · Cited by 128 · see citing works
Self-citationParikh, V., Man, K., Decker, M. W., & Sarter, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5251-07.2008 · Cited by 127 · see citing works
Self-citationIngham, C. A., Bolam, J. P., & Smith, A. D. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902730210 · Cited by 124 · see citing works
Wilens, T. E., Verlinden, M. H., Adler, L. A., Wozniak, P. J., & West, S. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.029 · Cited by 123 · see citing works
nAChR agonist-induced cognition enhancement: Integration of cognitive and neuronal mechanisms
Sarter, M., Parikh, V., & Howe, W. M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.019 · Cited by 123 · see citing works
Self-citationSarter, M. F., & Markowitsch, H. J. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902240312 · Cited by 121 · see citing works
Self-citationGolmayo, L., Núñez, Á., & Záborszky, L. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00031-9 · Cited by 120 · see citing works
The Nucleus Accumbens: A Switchboard for Goal-Directed Behaviors
Gruber, A. J., Hussain, R. J., & O’Donnell, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005062 · Cited by 119 · see citing works
Parikh, V., Pomerleau, F., Huettl, P., Gerhardt, G. A., Sarter, M., & Bruno, J. P. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03614.x · Cited by 117 · see citing works
Self-citationAigner, T. G., Walker, D. L., & Mishkin, M. (1991) · Behavioral and Neural Biology · doi:10.1016/0163-1047(91)80127-z · Cited by 117 · see citing works
Bentley, P., Driver, J., & Dolan, R. J. (2007) · Brain · doi:10.1093/brain/awm299 · Cited by 115 · see citing works
Bodick, N. C., Offen, W., Shannon, H. E., Satterwhite, J. H., Lucas, R., van Lier, R., & Paul, S. M. (1997) · PubMed · Cited by 113 · see citing works
Záborszky, L., Léránth, C., & Heimer, L. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90165-4 · Cited by 109 · see citing works
Smoking and attention: A review and reformulation of the stimulus-filter hypothesis
Kassel, J. D. (1997) · Clinical Psychology Review · doi:10.1016/s0272-7358(97)00032-9 · Cited by 109 · see citing works
Demeter, E., Hernández-García, L., Sarter, M. F., & Lustig, C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.026 · Cited by 107 · see citing works
Self-citationSelective effects of nicotine on attentional processes
Mancuso, G., Sherwood, N., Tirelli, E., Warburton, D. M., & M�len, M. (1999) · Psychopharmacology · doi:10.1007/s002130051107 · Cited by 106 · see citing works
Giessing, C., Thiel, C. M., Rösler, F., & Fink, G. R. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.005 · Cited by 104 · see citing works
Rats and humans paying attention: Cross-species task development for translational research.
Demeter, E., Sarter, M. F., & Lustig, C. (2008) · Neuropsychology · doi:10.1037/a0013712 · Cited by 104 · see citing works
Self-citationGaykema, R. P. A., & Záborszky, L. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961028)374:4 · Cited by 103 · see citing works
Psychophysiology at the Interface of Clinical Science, Cognitive Science, and Neuroscience
Dawson, M. E. (1990) · Psychophysiology · doi:10.1111/j.1469-8986.1990.tb00378.x · Cited by 102 · see citing works
Prompt but inefficient: nicotine differentially modulates discrete components of attention
Vangkilde, S., Bundesen, C., & Coull, J. T. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2361-x · Cited by 101 · see citing works
Cholinergic Enhancement Reduces Spatial Spread of Visual Responses in Human Early Visual Cortex
Silver, M. A., Shenhav, A., & D'Esposito, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.038 · Cited by 100 · see citing works
Deficits in attentional control: Cholinergic mechanisms and circuitry-based treatment approaches.
Sarter, M. F., & Paolone, G. (2011) · Behavioral Neuroscience · doi:10.1037/a0026227 · Cited by 98 · see citing works
Self-citationBehavioral screening for cognition enhancers: from indiscriminate to valid testing: Part II
Sarter, M. F., Hagan, J. J., & Dudchenko, P. A. (1992) · Psychopharmacology · doi:10.1007/bf02245257 · Cited by 97 · see citing works
Self-citationCerebral effects of nicotine during cognition in smokers and non-smokers
Ghatan, P. H., Ingvar, M., Eriksson, L., Stone‐Elander, S., Serrander, M., Ekberg, K., & Wahren, J. (1998) · Psychopharmacology · doi:10.1007/s002130050554 · Cited by 94 · see citing works
Evaluation of the information processing and mood effects of a transdermal nicotine patch
Warburton, D. M., & Mancuso, G. (1998) · Psychopharmacology · doi:10.1007/s002130050514 · Cited by 91 · see citing works
Attention – oscillations and neuropharmacology
Deco, G., & Thiele, A. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06833.x · Cited by 85 · see citing works
Hahn, B., Ross, T. J., Wolkenberg, F. A., Shakleya, D. M., Huestis, M. A., & Stein, E. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn226 · Cited by 85 · see citing works
Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats
Turchi, J. N., Holley, L. A., & Sarter, M. F. (1995) · Psychopharmacology · doi:10.1007/bf02245840 · Cited by 83 · see citing works
Self-citationSarter, M. F., Lustig, C., & Taylor, S. F. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.001 · Cited by 82 · see citing works
Self-citationVossel, S., Thiel, C. M., & Fink, G. R. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301469 · Cited by 81 · see citing works
Záborszky, L., Buhl, D. L., Pobalashingham, S., Bjaalie, J. G., & Nádasdy, Z. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.019 · Cited by 80 · see citing works
Chapter 3: Catecholaminergic-cholinergic interaction in the basal forebrain
Záborszky, L., Cullinan, W. E., & Luine, V. N. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62379-1 · Cited by 79 · see citing works
Dunbar, G. C., Inglis, F., Kuchibhatla, R., Sharma, T., Tomlinson, M., & Wamsley, J. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107066855 · Cited by 75 · see citing works
Nuechterlein, K. H., Snyder, K. S., & Mintz, J. (1992) · The British Journal of Psychiatry · doi:10.1192/s0007125000297109 · Cited by 72 · see citing works
Sunderland, T., Tariot, P. N., & NEWHOUSE, P. A. (1988) · Brain Research Reviews · doi:10.1016/0165-0173(88)90013-6 · Cited by 72 · see citing works
Reversal of a Vigilance Decrement in the Aged Rat by Subtype-Selective Nicotinic Ligands
Grottick, A. J., Haman, M., Wyler, R., & Higgins, G. A. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300102 · Cited by 68 · see citing works
Ettinger, U., Williams, S., Patel, D., Michel, T. M., Nwaigwe, A., Cáceres, A., Mehta, M. A., Anilkumar, A. P., & Kumari, V. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.029 · Cited by 67 · see citing works
Crossmodal divided attention in rats: effects of chlordiazepoxide and scopolamine
McGaughy, J. A., Turchi, J. N., & Sarter, M. F. (1994) · Psychopharmacology · doi:10.1007/bf02244774 · Cited by 67 · see citing works
Self-citationRokem, A., Landau, A. N., Garg, D., Prinzmetal, W., & Silver, M. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.118 · Cited by 65 · see citing works
Little, J. T. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00002-5 · Cited by 65 · see citing works
M1 Agonists as a Potential Disease-Modifying Therapy for Alzheimers Disease
Caccamo, A., Fisher, A., & LaFerla, F. M. (2009) · Current Alzheimer Research · doi:10.2174/156720509787602915 · Cited by 61 · see citing works
Rouse, S. T., Hamilton, S. E., Potter, L. T., Nathanson, N. M., & Conn, P. J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00914-3 · Cited by 59 · see citing works
Preclinical research into cognition enhancers
Sarter, M. F. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.09.004 · Cited by 56 · see citing works
Self-citationKozak, R., Martínez, V., Young, D. A., Brown, H. D., Bruno, J. P., & Sarter, M. F. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301352 · Cited by 53 · see citing works
Self-citationApostol, G., Abi‐Saab, W., Kratochvil, C. J., Adler, L. A., Robieson, W., Gault, L. M., Pritchett, Y., Feifel, D., Collins, M. A., & Saltarelli, M. D. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2393-2 · Cited by 52 · see citing works
Molecular and biophysical mechanisms of arousal, alertness, and attention
Pfaff, D. W., & Kieffer, B. L. (2008) · Cited by 46 · see citing works
Herzog, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00226-9 · Cited by 43 · see citing works
Positive effects of nicotine on cognition: the deployment of attention for prospective memory
Rusted, J. M., Sawyer, R., Jones, C. I., Trawley, S. L., & Marchant, N. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1320-7 · Cited by 41 · see citing works
Peters, M. S., Cherian, A. K., Bradshaw, M., & Sarter, M. F. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.025 · Cited by 38 · see citing works
Self-citationErskine, F. F., Ellis, J. R., Ellis, K. A., et al. (2004) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.613 · Cited by 36 · see citing works
Wilens, T. E., Gault, L. M., Childress, A. C., Kratochvil, C. J., Bensman, L., Hall, C. M., Olson, E., Robieson, W., Garimella, T. S., Abi‐Saab, W., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.10.001 · Cited by 34 · see citing works
Kohler, C. G., Martin, E. A., Kujawski, E., et al. (2007) · Cognitive Neuropsychiatry · doi:10.1080/13546800701307263 · Cited by 33 · see citing works
Cholinergic modulation of visual working memory during aging: A parametric PET study
Ricciardi, E., Pietrini, P., Schapiro, M. B., Rapoport, S. I., & Furey, M. L. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.01.013 · Cited by 30 · see citing works
Monitoring Molecules in Neuroscience
Sombers, L. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00592 · Cited by 29 · see citing works
Marchant, N. L., Trawley, S. L., & Rusted, J. M. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570700819x · Cited by 21 · see citing works
Mohler, E. G., Franklin, S. R., Rueter, L. E., Fox, G. B., Decker, M. W., & Browman, K. E. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.12.019 · Cited by 20 · see citing works
Regulation and function of the tonic component of cortical acetylcholine release.
Paolone, G., Howe, W., Gopalakrishnan, M., et al. (2010) · Institutional Research Information System University of Ferrara (University of Ferrara) · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Logue, S. F., & Gould, T. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.007 · Cited by 477 · see citing works
Hierarchical Prediction Errors in Midbrain and Basal Forebrain during Sensory Learning
Iglesias, S., Mathys, C., Brodersen, K. H., Kasper, L., Piccirelli, M., den Ouden, H. E. M., & Stephan, K. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.009 · Cited by 342 · see citing works
Oxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works
Freeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196 · see citing works
“Manipulations of the muscarinic cholinergic receptor or nicotinic cholinergic receptor have been suggested as a way of enhancing attention (47).”
BackgroundPharmacological enhancement of memory or cognition in normal subjects
Lynch, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00090 · Cited by 46 · see citing works
- Authors
- Demeter, E., & Sarter, M.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Demeter, Elise
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 64
- Pages
- 294-304
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC3445745
- OpenAlex
- W1971280731
- Cited by
- 75
- References
- 173
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 8 · 2012: 2
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH057436, R01MH086530)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention, nootropic drugs, nicotinic acetylcholine receptors, alpha4beta2 nAChR, prefrontal cortex, cue detection, attentional control, attentional impairment, neurodegenerative diseases
- MeSH terms
- Animals, Attention, Cholinesterase Inhibitors, Cognition Disorders, Humans, Nerve Tissue Proteins, Prefrontal Cortex, Nootropic Agents, Muscarinic Agonists, Nicotinic Agonists, Performance-Enhancing Substances, Molecular Targeted Therapy, Cholinergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review