Cited by 250Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Mechanisms underlying working memory for novel information

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Hasselmo, Michael E., Stern, Chantal E.·2006·Trends in Cognitive Sciences

Abstract

In this Opinion article we describe a theory that the brain mechanisms underlying working memory for novel information include a buffer in parahippocampal cortices. Computational modeling indicates that mechanisms for maintaining novel information in working memory could differ from mechanisms for maintaining familiar information. Electrophysiological data suggest that the buffer for novel information depends on acetylcholine. Acetylcholine activates single-cell mechanisms that underlie persistent spiking of neurons in the absence of synaptic transmission, allowing maintenance of information without prior synaptic modification. fMRI studies and lesion studies suggest that parahippocampal regions mediate working memory for novel stimuli, and the effects of cholinergic blockade impair this function. These intrinsic mechanisms in parahippocampal cortices provide an important alternative to theories of working memory based on recurrent synaptic excitation.

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Crossref · 10.1016/j.tics.2006.09.005

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  • Cholinergic induction of persistent spiking activity may contribute to active maintenance function in a range of different tasks.

    “Cholinergic induction of persistent spiking activity may contribute to active maintenance function in a range of different tasks (see Hasselmo and Stern, 2006 for review).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Hasselmo and Stern, 2006

  • These data indicate an important role of cholinergic modulation in providing active maintenance of a conditioned stimulus during the trace interval, possibly via induction of persistent spiking for bridging across time.

    “These data indicate the important role of cholinergic modulation in providing active maintenance of a conditioned stimulus during the trace interval, possibly via induction of the cellular mechanism of persistent spiking for bridging across the continuous dimension of time (Hasselmo and Stern, 2006).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Hasselmo and Stern, 2006

  • This supports the hypothesis that muscarinic activation of persistent spiking could underlie the maintenance of activity for encoding into long term memory.

    “This supports the hypothesis that muscarinic activation of persistent spiking could underlie the maintenance of activity for encoding into long term memory (Schon et al., 2005; Hasselmo and Stern, 2006).”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Hasselmo and Stern, 2006

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Authors
Hasselmo, M. E., & Stern, C. E.
Affiliations
Boston University (US)
Corresponding author
Hasselmo, Michael E.
Venue
Trends in Cognitive Sciences
Publisher
Elsevier BV
Published
2006-11
Volume
10
Issue
11
Pages
487-493
ISSN
1364-6613 (ISSN-L)
OpenAlex
W2154934134
Cited by
249
References
60
Citations by year
2026: 5 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 16 · 2014: 10 · 2013: 24 · 2012: 20
FWCI
1.31
Type
journal article
Language
en
Open access
Locations
  • Trends in Cognitive Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Science of Learning Centers (SBE0354378)
  • National Science Foundation
  • National Institutes of Health
  • National Institute of Mental Health (60013, 60450, 61492)
  • National Institute on Drug Abuse (16454)
  • National Institute of Neurological Disorders and Stroke (41636)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
working memory, novel information, parahippocampal cortex, acetylcholine, cholinergic blockade, synaptic transmission, memory maintenance, single-cell electrophysiology, cholinergic modulation
MeSH terms
Acetylcholine, Animals, Attention, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Memory, Short-Term, Synaptic Transmission, Neurons, Retention, Psychology, Long-Term Potentiation, Entorhinal Cortex, Parahippocampal Gyrus

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