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Cited by 527Parkinson's Disease Mechanisms and TreatmentsNeural and Behavioral Psychology StudiesCognitive Functions and Memory

The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.

Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: Evidence for a specific attentional dysfunction

Downes, J.J., Roberts, A.C., Sahakian, B.J., Evenden, J.L., Morris, R.G., Robbins, T.W.·1989·Neuropsychologia
DOI 10.1016/0028-3932(89)90128-0
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Abstract

Groups of patients with Parkinson's disease, either medicated, or unmedicated and early in the course, together with age- and IQ-matched control subjects were tested in two paradigms measuring different aspects of selective attention. The first set of tests compared visual discrimination learning following intra- and extra-dimensional shifts, using a "total change" design in which each shift was made in the presence of novel exemplars of the compound stimuli used as discriminanda. The second test consisted of a visual search task in which the number of alternatives was varied. The results of the first experiment showed a selective deficit in both groups of Parkinsonian subjects in their ability to perform an extra-dimensional shift. In the visual search task, the patients were less accurate, but responded with equivalent choice reaction times to those of controls. The results are discussed in terms of the nature of the attentional dysfunction that occurs in Parkinson's disease.

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Crossref · 10.1016/0028-3932(89)90128-0

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Metadata

Authors
Downes, J. J., Roberts, A. C., Sahakian, B. J., Evenden, J. L., Morris, R. G., & Robbins, T. W.
Affiliations
University of Cambridge (GB)
Corresponding author
Robbins, T.W.
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
1989-01
Volume
27
Issue
11-12
Pages
1329-1343
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/0028-3932(89)90128-0
OpenAlex
W2062147269
Cited by
527
References
39
Citations by year
2026: 2 · 2025: 4 · 2024: 15 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 8 · 2019: 9 · 2018: 12 · 2017: 14 · 2016: 16 · 2015: 26 · 2014: 12 · 2013: 18 · 2012: 14
FWCI
4.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
Parkinson's disease, selective attention, attentional dysfunction, visual discrimination learning, visual search, medication effects, early-stage Parkinson's disease, choice reaction time
MeSH terms
Aged, Attention, Drug Therapy, Combination, Female, Form Perception, Humans, Levodopa, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Pattern Recognition, Visual, Psychomotor Performance, Reaction Time, Trihexyphenidyl, Neurocognitive Disorders

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