The performance on learning tasks of patients in the early stages of Parkinson's disease
Abstract
It is known that in animals learning is disrupted by caudate lesions; but there has been no agreement about whether pathology in the basal ganglia causes a similar impairment in man. Nineteen patients in the early stages of Parkinson's disease were tested on two associative learning tasks and on the Wisconsin Card Sorting Task; and their performance was compared with that of patients with frontal or temporal lobe lesions. On the two associative learning tasks there was no overall difference between the Parkinsonian group and the controls. However, a minority of the Parkinsonian patients performed very poorly on these tasks; and it was noted that these tended to be the older patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some persons with PD demonstrate reduced inhibition of task-irrelevant information.
“Previous studies have reported that some persons with PD demonstrate reduced inhibition of task-irrelevant information (Canavan et al., 1989; Downes et al., 1989).”
From Perception of Physical Demand, Mental Demand, and Performance: A Comparison of Two Voice Interventions for Parkinson's Disease (2022) · cites this paper as Canavan et al., 1989
Cites
HOW COMMON IS DEMENTIA IN PARKINSON'S DISEASE?
Brown, R. G., & Marsden, C. D. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92807-1 · Cited by 320 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
Clinical diagnostic criteria for dementia associated with Parkinson’s disease
Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027 · see citing works
Self-citationGetting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works
Multiple dopamine functions at different time courses
Schultz, W. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135722 · Cited by 1,415 · see citing works
Schultz, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.007 · Cited by 1,028 · see citing works
Owen, A. M., Roberts, A. C., Polkey, C. E., Sahakian, B. J., & Robbins, T. W. (1991) · Neuropsychologia · doi:10.1016/0028-3932(91)90063-e · Cited by 657 · see citing works
Self-citationOwen, A. M., Roberts, A. C., Hodges, J. R., & Robbins, T. W. (1993) · Brain · doi:10.1093/brain/116.5.1159 · Cited by 639 · see citing works
Downes, J. J., Roberts, A. C., Sahakian, B. J., Evenden, J. L., Morris, R. G., & Robbins, T. W. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90128-0 · Cited by 527 · see citing works
Roberts, A., De Salvia, M., Wilkinson, L., Collins, P., Muir, J., Everitt, B., & Robbins, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02531.1994 · Cited by 415 · see citing works
Mechanisms of cognitive set flexibility in Parkinson's disease
Cools, R. (2001) · Brain · doi:10.1093/brain/124.12.2503 · Cited by 406 · see citing works
Crofts, H. S. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.11.1015 · Cited by 284 · see citing works
Cognitive deficits in Parkinson's disease: A cognitive neuroscience perspective
Robbins, T. W., & Cools, R. (2014) · Movement Disorders · doi:10.1002/mds.25853 · Cited by 235 · see citing works
Collins, P., Wilkinson, L. S., Everitt, B. J., Robbins, T. W., & Roberts, A. C. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.3 · Cited by 129 · see citing works
The left hemisphere and the selection of learned actions
Rushworth, M. F. S., Nixon, P. D., Wade, D. T., Renowden, S., & Passingham, R. E. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(97)00101-2 · Cited by 100 · see citing works
Self-citationA dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey
Oikonomidis, L., Santangelo, A. M., Shiba, Y., Clarke, F. H., Robbins, T. W., & Roberts, A. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22446 · Cited by 54 · see citing works
Richardson, K., Huber, J. E., Kiefer, B., & Snyder, S. (2022) · American Journal of Speech-Language Pathology · doi:10.1044/2022_ajslp-22-00026 · Cited by 9 · see citing works
- Authors
- Canavan, A. G. M., Passingham, R. E., Marsden, C. D., Quinn, N., Wyke, M., & Polkey, C. E.
- Affiliations
- University of Oxford (GB)
- ORCID
- Quinn, N.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 27
- Issue
- 2
- Pages
- 141-156
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2012298128
- Cited by
- 133
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, associative learning, Wisconsin Card Sorting Test, basal ganglia, caudate nucleus, frontal lobe lesions, temporal lobe lesions, learning disabilities, age effects, early-stage Parkinson's disease
- MeSH terms
- Adult, Aged, Association Learning, Basal Ganglia, Brain Damage, Chronic, Discrimination Learning, Female, Form Perception, Hippocampus, Humans, Learning, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Pattern Recognition, Visual, Psychomotor Performance, Temporal Lobe, Wechsler Scales
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
