Spiral artery blood flow in the central and peripheral areas of the placental bed in the second trimester
Abstract
OBJECTIVE: To assess impedance to blood flow through spiral arteries in the central and peripheral areas of the placental bed, to determine if in vivo findings are in concordance with histologic observations of cytotrophoblast invasion. METHODS: This study was cross-sectional, using transabdominal color flow and pulsed Doppler imaging in 64 women with normal, singleton pregnancies at 17-20 weeks' gestation. Spiral arteries were visualized by color Doppler in the central and peripheral parts of the placental bed, and blood flow was analyzed using pulsed Doppler to calculate the resistance index (RI) and the pulsatility index (PI). RESULTS: Visualization of flow in the spiral arteries was achieved in 100% of cases in the central area and in 95% in the periphery. Both the RI and PI were significantly lower in the center compared with the periphery (P < .001). There was no significant difference in the peak systolic velocities between the two areas. Regression analysis showed no significant difference in RI or PI at the different weeks of gestation in the central and peripheral areas of the placental bed. CONCLUSION: Impedance to blood flow through spiral arteries in the second trimester is lower in the central area of the placental bed, and is in agreement with previous histologic data. Physiologic change of the spiral arteries is functionally complete around 17 weeks' gestation.
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Normal uterine artery waveforms occur in cases of abdominal pregnancy where the spiral arteries are not exposed to any trophoblast.
“Further, it has been shown that normal UtA waveforms occur in cases of abdominal pregnancy where the spiral arteries are not exposed to any trophoblast [49].”
From Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta (2019) · cites this paper as [49]
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- Authors
- Matijevic, R.
- Venue
- Obstetrics & Gynecology
- Published
- 1995-08
- Volume
- 86
- Issue
- 2
- Pages
- 289-292
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2078660466
- Cited by
- 80
- References
- 20
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2016: 3 · 2015: 5 · 2013: 1 · 2012: 3
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- spiral arteries, placental blood flow, resistance index, pulsatility index, cytotrophoblast invasion, second trimester, peak systolic velocity, gestational age, color Doppler ultrasound, pulsed Doppler
- MeSH terms
- Adult, Blood Flow Velocity, Cross-Sectional Studies, Female, Humans, Placenta, Pregnancy, Pregnancy Trimester, Second, Pulsatile Flow, Vascular Resistance, Ultrasonography, Prenatal, Ultrasonography, Doppler, Placental Circulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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