Cited by 80Pregnancy and preeclampsia studiesReproductive System and PregnancyMaternal and fetal healthcare

Spiral artery blood flow in the central and peripheral areas of the placental bed in the second trimester

Matijevic, R·1995·Obstetrics & Gynecology

Abstract

OBJECTIVE: To assess impedance to blood flow through spiral arteries in the central and peripheral areas of the placental bed, to determine if in vivo findings are in concordance with histologic observations of cytotrophoblast invasion. METHODS: This study was cross-sectional, using transabdominal color flow and pulsed Doppler imaging in 64 women with normal, singleton pregnancies at 17-20 weeks' gestation. Spiral arteries were visualized by color Doppler in the central and peripheral parts of the placental bed, and blood flow was analyzed using pulsed Doppler to calculate the resistance index (RI) and the pulsatility index (PI). RESULTS: Visualization of flow in the spiral arteries was achieved in 100% of cases in the central area and in 95% in the periphery. Both the RI and PI were significantly lower in the center compared with the periphery (P < .001). There was no significant difference in the peak systolic velocities between the two areas. Regression analysis showed no significant difference in RI or PI at the different weeks of gestation in the central and peripheral areas of the placental bed. CONCLUSION: Impedance to blood flow through spiral arteries in the second trimester is lower in the central area of the placental bed, and is in agreement with previous histologic data. Physiologic change of the spiral arteries is functionally complete around 17 weeks' gestation.

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Crossref · 10.1016/0029-7844(95)00129-f

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Authors
Matijevic, R.
Venue
Obstetrics & Gynecology
Published
1995-08
Volume
86
Issue
2
Pages
289-292
ISSN
0029-7844 (ISSN-L)
OpenAlex
W2078660466
Cited by
80
References
20
Citations by year
2026: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2016: 3 · 2015: 5 · 2013: 1 · 2012: 3
FWCI
3.73
Type
journal article
Language
en
Open access
closed
Locations
  • Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
Keywords
spiral arteries, placental blood flow, resistance index, pulsatility index, cytotrophoblast invasion, second trimester, peak systolic velocity, gestational age, color Doppler ultrasound, pulsed Doppler
MeSH terms
Adult, Blood Flow Velocity, Cross-Sectional Studies, Female, Humans, Placenta, Pregnancy, Pregnancy Trimester, Second, Pulsatile Flow, Vascular Resistance, Ultrasonography, Prenatal, Ultrasonography, Doppler, Placental Circulation

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