Trophoblastic Oxidative Stress in Relation to Temporal and Regional Differences in Maternal Placental Blood Flow in Normal and Abnormal Early Pregnancies
Open accessAbstract
Onset of the maternal-placental circulation was studied by Doppler ultrasonography in 65 pairs of age-matched normal and abnormal pregnancies. In normal pregnancies intervillous blood flow increased with gestational age, being detected in 9 of 25 cases at 8 to 9 weeks but in 18 of 20 at 12 to 13 weeks (P = 0.001). By contrast, in abnormal pregnancies flow was detected in nearly all cases (22 of 25) at 8 to 9 weeks (P < 0.001). In addition, regional differences were observed between the groups. Early flow was restricted to the peripheral regions of most normal placentas (P < 0.001), whereas in missed miscarriages it was most common in central regions or throughout the placenta (P < 0.05 and P < 0.001, respectively). Immunoreactivity for heat shock protein 70 and nitrotyrosine residues was greater in samples from peripheral than from central regions of normal placentas (P = 0.028 and P = 0.019, respectively), and from missed miscarriages compared to controls (P = 0.005 and P = 0.001, respectively). Our results indicate that oxidative damage to the trophoblast, induced by premature and widespread onset of the maternal placental circulation secondary to shallow trophoblast invasion, is a key factor in early pregnancy loss. High oxygen concentrations in the periphery of normal early placentas may similarly induce local regression of the villi, leading to formation of the chorion laeve.
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Preeclampsia, miscarriages, preterm labour, birth defects, endometriosis, tubal factor infertility, intrauterine growth retardation, and stillbirth have been linked to insufficient trophoblast invasion, development, vascular remodeling, and impaired placental development and function.
“Preeclampsia, miscarriages, preterm labour, birth defects, endometriosis and tubal factor infertility, intrauterine growth retardation and stillbirth have been linked to insufficient trophoblast invasion, development, vascular remodeling and impaired placental development and function (Jauniaux et al., 2003, Szczepanska et al., 2003, Pringle et al, 2010)”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Jauniaux et al., 2003
The Discussion (page not specified in our copy) links reduced trophoblast invasion and inadequate vascular plugging to missed miscarriage, and discusses inadequately transformed uteroplacental arteries in pregnancies with intrauterine growth retardation or pregnancy-induced hypertension. It mentions preterm labour and stillbirth as risks following first-trimester subchorionic haemorrhage, not as direct consequences of insufficient trophoblast invasion. The passages do not link birth defects, endometriosis, or tubal factor infertility to the proposed placental mechanisms. (LLM, conf=0.88)
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Cites
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“…stillbirth have been linked to insufficient trophoblast invasion, development, vascular remodeling and impaired placental development and function (Jauniaux et al., 2003, Szczepanska et al., 2003, Pringle et al, 2010) In the event of placental hypoxia, due to defective placentation,…”
Background
- Authors
- Jauniaux, E., Hempstock, J., Greenwold, N., & Burton, G. J.
- Affiliations
- The Royal Free Hospital (GB)
- University of Cambridge (GB)
- Corresponding author
- Burton, Graham J.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 162
- Issue
- 1
- Pages
- 115-125
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1851128
- OpenAlex
- W2136170834
- Cited by
- 511
- References
- 1
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 25 · 2023: 19 · 2022: 24 · 2021: 25 · 2020: 20 · 2019: 24 · 2018: 26 · 2017: 20 · 2016: 27 · 2015: 27 · 2014: 25 · 2013: 18 · 2012: 27
- FWCI
- 27.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- placental blood flow, early pregnancy loss, missed abortion, HSP70, nitrotyrosine, chorion laeve, trophoblast invasion
- MeSH terms
- Abortion, Missed, Blood Flow Velocity, Female, Gestational Age, Humans, Immunohistochemistry, Oxygen, Placenta, Pregnancy, Trophoblasts, Ultrasonography, Prenatal, Oxidative Stress, HSP70 Heat-Shock Proteins, Placental Circulation
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