The DOI matches its Crossref record; 46 of the 50 references it cites were found in a registry or an index.
Long-term changes in open field behaviour following a single social defeat in rats can be reversed by sleep deprivation
Abstract
The long-term consequences of a single social defeat on open field behaviour in rats were studied, with special emphasis on the time course of stress-induced changes. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for 1 h. After the defeat session experimental animals were returned to their home cage and their own room, receiving no further cues from the resident. Other animals serving as controls were placed in a clean and empty cage for 1 h. Five-minute open field tests were performed on days 1, 2, 7, 14, and 28 after defeat, with independent groups of rats. Locomotion of the animals was recorded and analyzed with an automated video system. Social defeat resulted in a strong subsequent reduction in open field activity, which lasted till at least 7 days after the conflict. Differences in total travelled distance were no longer significant 2 weeks after the conflict. The latency for moving to the outer ring of the open field arena after the start of the test was still significantly longer 4 weeks after defeat. The stress-induced reduction in open field locomotion could be reversed by 12-h sleep deprivation during the resting phase, an intervention known to have antidepressant effects in humans. Possible relevance of the present findings with respect to human affective disorders is discussed.
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“Interestingly, a 12-hour sleep deprivation that is applied by using a slowly rotating drum which minimizes physical stress, but does produce locomotor activity, reversed the decreased open-field behavior induced by a single social defeat.40”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [40]
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“Though previous studies on a single social defeat did not focus on floating behavior [29,54,55], it is well documented that repeated social defeat prolongs an immobilization time in FST, indicating the development of helplessness and despair in animals.”
BackgroundAcute social defeat does not alter cerebral 5‐HT2A receptor binding in male Wistar rats
Visser, A. K. D., Meerlo, P., Ettrup, A., Knudsen, G. M., Bosker, F. J., den Boer, J. A., Dierckx, R., & van Waarde, A. (2014) · Synapse · doi:10.1002/syn.21750 · Cited by 11
“Some studies did find an effect of social defeat on OF behavior, using different strains of rats (Tyron Maze Dull S3, Taconic Wistar) (Kinn Rod et al., 2012; Meerlo et al., 1996a, 1996b).”
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“…avoidance in a social approach and avoidance test, increased startle response, and a decreased preference for sucrose (Hollis et al., 2010; McCormick et al., 2008; Meerlo et al., 1996; Nakayasu and Ishii, 2008; Pulliam et al., 2010; Rygula et al., 2005; Schmidt et al., 2010; Watt et al., 2009).”
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Qiao, M.-Q. (2014) · Medical Science Monitor · doi:10.12659/msm.890200 · Cited by 6
“These procedures minimize injury while emphasizing the psychosocial component of the stress [9,10].”
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“Sleep deprivation, antidepressants such as clomipramine, imipramine, fluoxetine as well as social interaction can prevent many consequences of social stress [62,63,65,66,67].”
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MacKay, J. C. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5621 · Cited by 1
“Furthermore, social avoidance/decreased social contact following defeat has been reported in both mice (Berton et al., 2006; Krishnan et al., 2007; Meerlo et al., 1996; Tsankova et al., 2006) and rats (Hollis et al., 2010; Kudryavtseva, 2003; Razzoli et al., 2007).”
Influentialdo Amaral, C. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2012.tde-30012013-091938
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Heightened Muscle Tension in Rodent Model of PTSD
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“…Pulliam et al., 2010), neophobia and anxiety-like behavior (Becker et al., 2001; Chen et al., 2024; Harada et al., 2024; Kinn Rod et al., 2012; Meerlo et al., 1996; Skutella et al., 1994), reactivity to mild stressors (Gautam et al., 2018; Koolhaas et al., 1997), sleep fragmentation and…”
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“In general, defeated animals are less active, have decreased locomotor activity and display decreased food and liquid consumption, hallmarks of anhedonia (Meerlo et al. 1996; Meerlo et al. 1996).”
Background
Metadata
- Authors
- Meerlo, P., Overkamp, G. J. F., Benning, M. A., Koolhaas, J. M., & Van Den Hoofdakker, R. H.
- Affiliations
- University of Groningen (NL)
- Corresponding author
- Meerlo, P.
- ORCID
- Meerlo, P.
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 60
- Issue
- 1
- Pages
- 115-119
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2032960831
- Cited by
- 151
- References
- 50
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 12 · 2013: 6 · 2012: 9
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social defeat, sleep deprivation, open field behavior, locomotor activity, stress, antidepressant effects, mood disorders, rats, territorial aggression
- MeSH terms
- Affect, Aggression, Agonistic Behavior, Animals, Arousal, Dominance-Subordination, Exploratory Behavior, Male, Motor Activity, Rats, Inbred Strains, Reaction Time, Sleep Deprivation, Rats
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