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Long-term changes in open field behaviour following a single social defeat in rats can be reversed by sleep deprivation
Abstract
The long-term consequences of a single social defeat on open field behaviour in rats were studied, with special emphasis on the time course of stress-induced changes. Animals were subjected to social defeat by placing them into the territory of an aggressive male conspecific for 1 h. After the defeat session experimental animals were returned to their home cage and their own room, receiving no further cues from the resident. Other animals serving as controls were placed in a clean and empty cage for 1 h. Five-minute open field tests were performed on days 1, 2, 7, 14, and 28 after defeat, with independent groups of rats. Locomotion of the animals was recorded and analyzed with an automated video system. Social defeat resulted in a strong subsequent reduction in open field activity, which lasted till at least 7 days after the conflict. Differences in total travelled distance were no longer significant 2 weeks after the conflict. The latency for moving to the outer ring of the open field arena after the start of the test was still significantly longer 4 weeks after defeat. The stress-induced reduction in open field locomotion could be reversed by 12-h sleep deprivation during the resting phase, an intervention known to have antidepressant effects in humans. Possible relevance of the present findings with respect to human affective disorders is discussed.
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“Interestingly, a 12-hour sleep deprivation that is applied by using a slowly rotating drum which minimizes physical stress, but does produce locomotor activity, reversed the decreased open-field behavior induced by a single social defeat.40”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [40]
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“Interestingly, a 12-hour sleep deprivation that is applied by using a slowly rotating drum which minimizes physical stress, but does produce locomotor activity, reversed the decreased open-field behavior induced by a single social defeat.(40)”
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Metadata
- Authors
- Meerlo, P., Overkamp, G. J. F., Benning, M. A., Koolhaas, J. M., & Van Den Hoofdakker, R. H.
- Affiliations
- University of Groningen (NL)
- Corresponding author
- Meerlo, P.
- ORCID
- Meerlo, P.
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 60
- Issue
- 1
- Pages
- 115-119
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2032960831
- Cited by
- 151
- References
- 50
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 12 · 2013: 6 · 2012: 9
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social defeat, sleep deprivation, open field behavior, locomotor activity, stress, antidepressant effects, mood disorders, rats, territorial aggression
- MeSH terms
- Affect, Aggression, Agonistic Behavior, Animals, Arousal, Dominance-Subordination, Exploratory Behavior, Male, Motor Activity, Rats, Inbred Strains, Reaction Time, Sleep Deprivation, Rats
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