Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones
Abstract
Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua, from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The more abundant methoxylated flavonoids from A. annua include casticin (227), artemetin (228), chrysosplenol D (225) and chrysoplenetin (226).
“These flavones include: casticin (227), artemetin (228) [91], chrysosplenol D (225) and chrysoplenetin (226) [92]”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [91]
Cites
Synchronization of Plasmodium falciparum Erythrocytic Stages in Culture
Lambros, C., & Vanderberg, J. P. (1979) · Journal of Parasitology · doi:10.2307/3280287 · Cited by 3,695 · see citing works
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique
Desjardins, R. E., Canfield, C. J., Haynes, J. D., & Chulay, J. D. (1979) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.16.6.710 · Cited by 2,517 · see citing works
ANTIMALARIAL ACTIVITY OF MEFLOQUINE AND QINGHAOSU
Jiang, J., Guo, X.-B., Li, G., Kong, Y. C., & Arnold, K. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90268-9 · Cited by 194 · see citing works
Ferrell, J. E., Sing, P. D. G. C., Loew, G. H., King, R., Mansour, J. M., & Mansour, T. E. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13785-1 · Cited by 111 · see citing works
Cochet, C., Feige, J., Pirollet, F., Kéramidas, M., & CHAMBAZ, E. M. (1982) · Biochemical Pharmacology · doi:10.1016/0006-2952(82)90028-4 · Cited by 101 · see citing works
Elford, B. C., Haynes, J. D., Chulay, J. D., & Wilson, R. J. (1985) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(85)90048-9 · Cited by 100 · see citing works
Antineoplastic Activity and Cytotoxicity of Flavones, Isoflavones, and Flavanones
Edwards, J. M., Raffauf, R. F., & Quesne, P. W. L. (1979) · Journal of Natural Products · doi:10.1021/np50001a002 · Cited by 75 · see citing works
Bras, J. L., Deloron, P., Ricour, A., Andrieu, B., Savel, J., & Couláud, J. P. (1983) · Experimental Parasitology · doi:10.1016/0014-4894(83)90091-7 · Cited by 45 · see citing works
Li, Z. L., Gu, H. M., Warhurst, D. C., & Peters, W. (1983) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(83)90129-3 · Cited by 43 · see citing works
6-Methoxyflavonols from Brickellia veronicaefolia (compositae)
ROBERTS, M. F., Timmermann, B. N., & Mabry, T. J. (1980) · Phytochemistry · doi:10.1016/0031-9422(80)85028-x · Cited by 34 · see citing works
S-antigens and isozymes in strains of Plasmodium falciparum
Hempelmann, E., Ling, I. T., & Wilson, R. J. (1981) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(81)90431-4 · Cited by 32 · see citing works
Wiser, M. F., Eaton, J. W., & Sheppard, J. R. (1983) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240210407 · Cited by 26 · see citing works
Effects of oligomycin and quercetin on the hydrolytic activities of the (Na+ + K+)-dependent ATPase
Robinson, J. D., Robinson, L. J., & Martin, N. J. (1984) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(84)90146-9 · Cited by 20 · see citing works
Quercetagetin 6,7,3′,4′-tetramethyl ether: A new flavonol from Artemisia annua
Djermanović, M., Jokić, A., Mladenović, S., & Stefanović, M. (1975) · Phytochemistry · doi:10.1016/0031-9422(75)85317-9 · Cited by 18 · see citing works
History and Current Status of Drug Resistance
Peters, W. (1984) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-69251-2_16 · Cited by 14 · see citing works
PHOTODYNAMIC ACTION OF CHEMICALLY RELATED FLAVONES
Nishie, K., Waiss, A. C., & Keyl, A. C. (1968) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1968.tb05864.x · Cited by 12 · see citing works
A compact semi-automated continuous cultivation system for Plasmodium falciparum
Scott-Finnigan, T. J., Wilson, R. J., & Williamson, J. (1981) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(81)90338-2 · Cited by 9 · see citing works
History and Current Status of Drug Resistance
Peters, W. (1984) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-35326-4_16 · Cited by 8 · see citing works
New answers through chemotherapy?
Peters, W. (1984) · Cellular and Molecular Life Sciences · doi:10.1007/bf01951888 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956 · see citing works
Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2
Caesar, L. K., & Cech, N. B. (2019) · Natural Product Reports · doi:10.1039/c9np00011a · Cited by 940 · see citing works
Rasoanaivo, P., Wright, C. W., Willcox, M. L., & Gilbert, B. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-s1-s4 · Cited by 566 · see citing works
Ferreira, J., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010) · Molecules · doi:10.3390/molecules15053135 · Cited by 532 · see citing works
Vaou, N., Stavropoulou, E., Voidarou, C. C., Tsakris, Z., Rozos, G., Tsigalou, C., & Bezirtzoglou, E. (2022) · Antibiotics · doi:10.3390/antibiotics11081014 · Cited by 475 · see citing works
Natural products as antiparasitic drugs
Kayser, O., Kiderlen, A. F., & Croft, S. L. (2003) · Parasitology Research · doi:10.1007/s00436-002-0768-3 · Cited by 373 · see citing works
The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
Meshnick, S. R., Taylor, T. E., & Kamchonwongpaisan, S. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.2.301-315.1996 · Cited by 710 · see citing works
“Further evidence includes observations that the in vitro antimalarial activities of artemisinin and artesunate are enhanced by high oxygen tension and by the addition of other free-radical-generating compounds, such as doxorubicin, miconazole (81), castecin, and artemitin (36).”
BackgroundScreening Tanzanian medicinal plants for antimalarial activity
Gessler, M. C., Nkunya, M. H. H., Mwasumbi, L. B., Heinrich, M., & Tanner, M. (1994) · Acta Tropica · doi:10.1016/0001-706x(94)90041-8 · Cited by 275 · see citing works
Current status of artemisinin and its derivatives as antimalarial drugs
Dhingra, V., Rao, K. V., & Narasu, M. L. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00356-2 · Cited by 241 · see citing works
Antimalarial compounds isolated from plants used in traditional medicine
Bero, J., Frédérich, M., & Quetin‐Leclercq, J. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.11.0001 · Cited by 214 · see citing works
Brandão, M. G. L., Krettli, A. U., Soares, L. S. R., Nery, C. G. C., & MARINUZZI, H. C. (1997) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(97)00060-3 · Cited by 210 · see citing works
Natural products and the development of selective antiprotozoal drugs
Wright, C. W., & Phillipson, J. D. (1990) · Phytotherapy Research · doi:10.1002/ptr.2650040402 · Cited by 202 · see citing works
Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures
Liu, K. C.-S., Yang, S., ROBERTS, M. F., Elford, B. C., & Phillipson, J. D. (1992) · Plant Cell Reports · doi:10.1007/bf00236389 · Cited by 189 · see citing works
Natural products as starting points for future anti-malarial therapies: going back to our roots?
Wells, T. N. C. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-s1-s3 · Cited by 177 · see citing works
Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite
Lehane, A. M., & Saliba, K. J. (2008) · BMC Research Notes · doi:10.1186/1756-0500-1-26 · Cited by 175 · see citing works
Mueller, M. S., Balagizi, I. K., Hirt, H. M., & Wemakor, E. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00289-0 · Cited by 172 · see citing works
In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe
Kraft, C., Jenett‐Siems, K., Siems, K., Jakupovic, J., Mavi, S., Bienzle, U., & Eich, E. (2003) · Phytotherapy Research · doi:10.1002/ptr.1066 · Cited by 166 · see citing works
Ngarivhume, T., Klooster, C. V., de Jong, J. T. V. M., & van der Westhuizen, J. H. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.11.011 · Cited by 162 · see citing works
Ginsburg, H., & Deharo, E. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-s1-s1 · Cited by 162 · see citing works
Natural products active against African trypanosomes: a step towards new drugs
Hoet, S., Opperdoes, F. R., Brun, R., & Quetin‐Leclercq, J. (2004) · Natural Product Reports · doi:10.1039/b311021b · Cited by 156 · see citing works
Natural Products Active Against African Trypanosomes: A Step Towards New Drugs
Hoet, S., Opperdoes, F. R., Brun, R., & Quetin‐Leclercq, J. (2004) · ChemInform · doi:10.1002/chin.200435271 · Cited by 136 · see citing works
Phytochemistry and pharmacognosy
Phillipson, J. D. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.06.028 · Cited by 132 · see citing works
Can ethnopharmacology contribute to the development of antimalarial agents?
Phillipson, J. D., & Wright, C. W. (1991) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(91)90113-r · Cited by 131 · see citing works
Dried Whole Plant Artemisia annua as an Antimalarial Therapy
Elfawal, M. A., Towler, M. J., Reich, N. G., Golenbock, D. T., Weathers, P. J., & Rich, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052746 · Cited by 128 · see citing works
Oliveira, F. Q., de Andrade‐Neto, V. F., Krettli, A. U., & Brandão, M. G. L. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.03.026 · Cited by 128 · see citing works
Artemisia Species: From Traditional Medicines to Modern Antimalarials—and Back Again
Willcox, M. L. (2009) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2008.0327 · Cited by 121 · see citing works
In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle
Asres, K., Bučar, F., Knauder, E., Yardley, V., Kendrick, H. D., & Croft, S. L. (2001) · Phytotherapy Research · doi:10.1002/ptr.897 · Cited by 118 · see citing works
Bilia, A. R., de Magalhães, P. M., Bergonzi, M. C., & Vincieri, F. F. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.01.008 · Cited by 115 · see citing works
Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents
Biot, C., Delhaès, L., Maciejewski, L. A., Mortuaire, M., Camus, D., Dive, D., & Brocard, J. S. (2000) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(00)00178-1 · Cited by 108 · see citing works
Phillipson, J. D. (1994) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(94)90464-2 · Cited by 103 · see citing works
de Magalhães, P. M., Dupont, I. E., Hendrickx, A., Joly, A., Raas, T., Dessy, S., Sergent, T., & Schneider, Y. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.195 · Cited by 98 · see citing works
Plant Derived Antimalarial Agents: New Leads and Challenges
Wright, C. W. (2005) · Phytochemistry Reviews · doi:10.1007/s11101-005-3261-7 · Cited by 96 · see citing works
Suberu, J., Gorka, A. P., Jacobs, L., Roepe, P. D., Sullivan, N., Barker, G. C., & Lapkin, A. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080790 · Cited by 92 · see citing works
Medicinal plants and the control of protozoal disease, with particular reference to malaria
Kirby, G. C. (1996) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(96)90404-6 · Cited by 87 · see citing works
Natural products as potential antiparasitic drugs
Kayser, O., Kiderlen, A. F., & Croft, S. L. (2002) · Studies in natural products chemistry · doi:10.1016/s1572-5995(02)80019-9 · Cited by 83 · see citing works
Antimalarial natural products: a review.
Mojab, F. (2012) · Europe PMC (PubMed Central) · Cited by 82 · see citing works
Panda, S. K., & Luyten, W. H. M. L. (2018) · Parasite · doi:10.1051/parasite/2018008 · Cited by 81 · see citing works
Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum
Tiffert, T., Ginsburg, H., Krugliak, M., Elford, B. C., & Lew, V. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.331 · Cited by 81 · see citing works
The mode of action of the antimalarial artemisinin and its derivatives
Kamchonwongpaisan, S., & Meshnick, S. R. (1996) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(95)02047-0 · Cited by 77 · see citing works
Distribution of artemisinin and bioactive flavonoids from Artemisia annua L. during plant growth
Baraldi, R., Isacchi, B., Predieri, S., Marconi, G., Vincieri, F. F., & Bilia, A. R. (2008) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2007.11.002 · Cited by 77 · see citing works
Wright, C. W., Linley, P. A., Brun, R., Wittlin, S., & Hsü, E. (2010) · Molecules · doi:10.3390/molecules15020804 · Cited by 77 · see citing works
Improved Traditional Phytomedicines in Current Use for the Clinical Treatment of Malaria
Willcox, M. L. (2011) · Planta Medica · doi:10.1055/s-0030-1250548 · Cited by 76 · see citing works
Phillipson, J. D. (1995) · Phytochemistry · doi:10.1016/0031-9422(94)00780-w · Cited by 75 · see citing works
Artemisia annua L.: a source of novel antimalarial drugs
Woerdenbag, H. J., Lugt, C., & Pras, N. (1990) · Pharmacy World & Science · doi:10.1007/bf01980041 · Cited by 73 · see citing works
Dried-leaf Artemisia annua : A practical malaria therapeutic for developing countries?
Weathers, P. J. (2014) · World Journal of Pharmacology · doi:10.5497/wjp.v3.i4.39 · Cited by 72 · see citing works
Antimalarial Principles from Artemisia indica
Chanphen, R., Thebtaranonth, Y., Wanauppathamkul, S., & Yuthavong, Y. (1998) · Journal of Natural Products · doi:10.1021/np980041x · Cited by 72 · see citing works
In vitro antiplasmodial activity of Central American medicinal plants
Jenett‐Siems, K., Mockenhaupt, F. P., Bienzle, U., Gupta, M. P., & Eich, E. (1999) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1999.00456.x · Cited by 72 · see citing works
Herbalism, Phytochemistry and Ethnopharmacology
Singh, A. (2011) · CRC Press eBooks · doi:10.1201/b10878 · Cited by 71 · see citing works
Ethnopharmacology and malaria: New hypothetical leads or old efficient antimalarials?
Bourdy, G., Willcox, M. L., Ginsburg, H., Rasoanaivo, P., Graz, B., & Deharo, E. (2007) · International Journal for Parasitology · doi:10.1016/j.ijpara.2007.07.004 · Cited by 67 · see citing works
van der Kooy, F., & Sullivan, S. E. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.08.021 · Cited by 66 · see citing works
Muthaura, C. N., Keriko, J. M., Derese, S., Yenesew, A., & Rukunga, G. M. (2010) · Experimental Parasitology · doi:10.1016/j.exppara.2010.11.004 · Cited by 64 · see citing works
Bailey, N. J. C., Wang, Y., Sampson, J., Davis, W. A., Whitcombe, I. W. A., Hylands, P. J., Croft, S. L., & Holmes, E. C. (2004) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2003.12.024 · Cited by 62 · see citing works
Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts
Czechowski, T., Rinaldi, M. A., Famodimu, M. T., van Veelen, M., Larson, T. R., Winzer, T., Rathbone, D. A., Harvey, D., Horrocks, P., & Graham, I. A. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00984 · Cited by 61 · see citing works
In vitro antimalarial activity of flavonoid derivatives dehydrosilybin and 8-(1;1)-DMA-kaempferide
de Monbrison, F., Maitrejean, M., Latour, C., Bugnazet, F., Peyron, F., Barron, D., & Picot, S. (2005) · Acta Tropica · doi:10.1016/j.actatropica.2005.09.004 · Cited by 55 · see citing works
1. Medicinal plants against protozoal diseases
Phillipson, J. D., & Wright, C. W. (1991) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(91)90139-p · Cited by 55 · see citing works
Weathers, P. J., Elfawal, M. A., Towler, M. J., Acquaah-Mensah, G. K., & Rich, S. M. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.03.037 · Cited by 54 · see citing works
Recent developments in research on terrestrial plants used for the treatment of malaria
Wright, C. W. (2010) · Natural Product Reports · doi:10.1039/c002196m · Cited by 54 · see citing works
Natural Products as Leads for New Pharmaceuticals
Buss, A. D., Cox, B. J., & Waigh, R. D. (2003) · Burger's Medicinal Chemistry and Drug Discovery · doi:10.1002/0471266949.bmc018 · Cited by 54 · see citing works
Towler, M. J., & Weathers, P. J. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.01.007 · Cited by 51 · see citing works
Donno, A. D., Grassi, T., Idolo, A., Guido, M., Papadia, P., Caccioppola, A., Villanova, L., Merendino, A., Bagordo, F., & Fanizzi, F. P. (2012) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2012.07.008 · Cited by 53 · see citing works
Plants as Sources of Natural and Recombinant Antimalaria Agents
Habibi, P., Shi, Y., Grossi‐de‐Sá, M. F., & Khan, I. H. (2022) · Molecular Biotechnology · doi:10.1007/s12033-022-00499-9 · Cited by 51 · see citing works
Qinghaosu (Artemisinin) as an Antimalarial Drug
Trigg, P. I. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-730064-1.50006-9 · Cited by 51 · see citing works
Willcox, M. L., Burton, S., Oyweka, R., Namyalo, R., Challand, S., & Lindsey, K. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-84 · Cited by 46 · see citing works
Methoxylated flavones and coumarins from Artemisia annua
Shilin, Y., ROBERTS, M. F., & Phillipson, J. D. (1989) · Phytochemistry · doi:10.1016/s0031-9422(00)97776-8 · Cited by 43 · see citing works
Natural Products Drug Discovery
Appendino, G., Fontana, G., & Pollastro, F. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00064-2 · Cited by 43 · see citing works
Munyangi, J., Cornet-Vernet, L., Idumbo, M., Lu, C., Lutgen, P., Perronne, C., Ngombe, N., Bianga, J., Mupenda, B., Lalukala, P., et al. (2019) · Phytomedicine · doi:10.1016/j.phymed.2018.12.002 · Cited by 38 · see citing works
RetractedSmith, S. L., Sadler, C. J., Dodd, C. C., Edwards, G., Ward, S. A., Park, B. K., & McLean, W. G. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00556-6 · Cited by 40 · see citing works
Ethnomedicinal Plants Traditionally Used by the Keiyo Community in Elgeyo Marakwet County, Kenya
Kigen, G. (2014) · Journal of Biodiversity Bioprospecting and Development · doi:10.4172/2376-0214.1000132 · Cited by 37 · see citing works
Antiplasmodial activity of sesquilignans and sesquineolignans from Bonamia spectabilis
Kraft, C., Jenett‐Siems, K., Köhler, I., Tofern, B., Siems, K., Bienzle, U., & Eich, E. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00101-2 · Cited by 36 · see citing works
Tabrez, S. S. M., Rahman, F., Ali, R. A., Alouffi, A., Akand, S. K., Alshehri, B., Alshammari, F. A., Alam, A., Alaidarous, M., Banawas, S., et al. (2020) · Bioscience Reports · doi:10.1042/bsr20203857 · Cited by 34 · see citing works
Tropical Plants as Sources of Antiprotozoal Agents
Phillipson, J. D., Wright, C. W., Kirby, G. C., & Warhurst, D. C. (1993) · Springer eBooks · doi:10.1007/978-1-4899-1783-6_1 · Cited by 34 · see citing works
The herbal tea approach for artemisinin as a therapy for malaria?
Jansen, F. H. (2005) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2005.08.004 · Cited by 34 · see citing works
Suberu, J., Gorka, A. P., Jacobs, L., Roepe, P. D., Sullivan, N., Barker, G. C., & Lapkin, A. A. (2013) · PLoS ONE · doi:10.1371/annotation/57ae25b0-d2c8-444b-ab62-f047c5f3e01e · Cited by 33 · see citing works
Braguine, C. G., Costa, E. S., Magalhães, L. G., Rodrigues, V., Filho, A. A. D. S., Bastos, J. K., Silva, M. L. A. E., Cunha, W. R., Januário, A. H., & Pauletti, P. M. (2009) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2009-11-1207 · Cited by 32 · see citing works
Wei, S., Ji, H., Yang, B., Ma, L., Bei, Z., Li, X., Dang, H., Yang, X., Liu, C., Wu, X., et al. (2015) · Malaria Journal · doi:10.1186/s12936-015-0929-3 · Cited by 32 · see citing works
Synergy in Herbal Medicines: Part 1
Yarnell, E. L. (2015) · Journal of Restorative Medicine · doi:10.14200/jrm.2015.4.0104 · Cited by 31 · see citing works
Desrosiers, M. R., & Weathers, P. J. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.06.041 · Cited by 31 · see citing works
Flavonoids and chromenes from Artemisia annua
Yang, S., ROBERTS, M. F., O’Neill, M. J., Bučar, F., & Phillipson, J. D. (1995) · Phytochemistry · doi:10.1016/0031-9422(94)00591-g · Cited by 31 · see citing works
Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria
Weathers, P. J., Jordan, N. J., Lasin, P., & Towler, M. J. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.11.043 · Cited by 30 · see citing works
Qiu, F., Wu, S., Lu, X., Zhang, C., Li, J., Gong, M., & Wang, M. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.03.043 · Cited by 29 · see citing works
Plants as a Source of Antimalarial Drugs
Kirby, G. C. (1997) · Tropical Doctor · doi:10.1177/00494755970270s105 · Cited by 28 · see citing works
Antiprotozoal Effect of Artemisia indica Extracts and Essential Oil
Taşdemir, D., Tierney, M. S., Sen, R., Bergonzi, M. C., Demırcı, B., Bilia, A. R., Başer, K. H. C., Brun, R., & Chatterjee, M. (2015) · Planta Medica · doi:10.1055/s-0035-1546125 · Cited by 27 · see citing works
Qiao, Z., Cheng, Y., Liu, S., Ma, Z., Li, S., & Zhang, W. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-018-1574-5 · Cited by 26 · see citing works
Antiparasitic Agents from Plants
Borris, R. P., & Schaeffer, J. M. (1992) · Springer eBooks · doi:10.1007/978-1-4899-2584-8_6 · Cited by 26 · see citing works
A Safety Assessment of the Antimalarial Herb Artemisia annua During Pregnancy in Wistar Rats
Abolaji, A. O., Eteng, M. U., Ebong, P. E., Brisibe, E. A., Dar, A., Kabir, N., & Choudhary, M. I. (2012) · Phytotherapy Research · doi:10.1002/ptr.4760 · Cited by 24 · see citing works
Kamaraj, C., Ragavendran, C., Kumar, R. C. S., Ali, A., Khan, S. U., Mashwani, Z., Luna‐Arias, J. P., & Pedroza, J. P. R. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2022.100377 · Cited by 23 · see citing works
Chibale, K., Masimirembwa, C. M., & Davies-Coleman, M. (2012) · Springer eBooks · doi:10.1007/978-3-642-28175-4 · Cited by 25 · see citing works
Search for New Drugs of Plant Origin
Hamburger, M. O., Marston, A., & Hostettmann, K. (1991) · Advances in Drug Research · doi:10.1016/b978-0-12-013320-8.50007-1 · Cited by 23 · see citing works
Silva, E. D. O., Borges, L. L., da Conceição, E. C., & Bara, M. T. F. (2017) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2017.03.002 · Cited by 22 · see citing works
The Mechanism of Antimalarial Action of Artemisinin (Qinghaosu)
Kamchonwongpaisan, S., Vanitchareon, N., & Yuthavong, Y. (1992) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7432-8_30 · Cited by 22 · see citing works
Atemnkeng, M. A., Chimanuka, B., Dejaegher, B., Heyden, Y. V., & Plaizier-vercammen, J. A. (2009) · Experimental Parasitology · doi:10.1016/j.exppara.2009.04.004 · Cited by 21 · see citing works
Mouton, J., Jansen, O., Frédérich, M., & van der Kooy, F. (2013) · Planta Medica · doi:10.1055/s-0032-1328324 · Cited by 20 · see citing works
The Synergy Principle at Work with Plants, Pathogens, Insects, Herbivores, and Humans
Cseke, L. J., Kirakosyan, A., Kaufman, P. B., Warber, S., Duke, J. A., & Brielmann, H. L. (2016) · CRC Press eBooks · doi:10.1201/9781420004472-17 · Cited by 20 · see citing works
Woerdenbag, H. J., Merfort, I., Schmidt, T. J., Passreiter, C. M., Willuhn, G., van Uden, W., Pras, N., & Konings, A. W. T. (1995) · Phytomedicine · doi:10.1016/s0944-7113(11)80057-7 · Cited by 19 · see citing works
Whole Plant Approaches to Therapeutic Use of Artemisia annua L. (Asteraceae)
Weathers, P. J., Reed, K., Hassanali, A., Lutgen, P., & Engeu, P. O. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_4 · Cited by 18 · see citing works
Awuchi, C. G., & Morya, S. (2023) · doi:10.1002/9781119793007.ch2 · Cited by 18 · see citing works
Botanical Treatment and Prevention of Malaria: Part 2—Selected Botanicals
Yarnell, E. L., & Abascal, K. (2004) · Alternative and Complementary Therapies · doi:10.1089/act.2004.10.277 · Cited by 17 · see citing works
Eteng, M. U., Abolaji, A. O., Ebong, P. E., Brisibe, E. A., Dar, A., Kabir, N., & Choudhary, M. I. (2012) · Phytotherapy Research · doi:10.1002/ptr.4758 · Cited by 16 · see citing works
New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae)
Bertani, S., Houël, E., Jullian, V., Bourdy, G., Valentin, A., Stien, D., & Deharo, E. (2012) · Experimental Parasitology · doi:10.1016/j.exppara.2012.02.013 · Cited by 16 · see citing works
- Authors
- Elford, B. C., Roberts, M. F., Phillipson, J. D., & Wilson, R. J. M.
- Affiliations
- University of London (GB)
- ORCID
- Wilson, Robert J.M.
- Venue
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-01
- Volume
- 81
- Issue
- 3
- Pages
- 434-436
- ISSN
- 0035-9203 (ISSN-L)
- OpenAlex
- W2121036679
- Cited by
- 159
- References
- 18
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 10
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Keywords
- artemisinin, methoxylated flavones, casticin, artemetin, chloroquine resistance, Plasmodium falciparum, Artemisia annua, drug interactions, antimalarial activity
- MeSH terms
- Animals, Antimalarials, Clone Cells, Dose-Response Relationship, Drug, Drug Synergism, Flavonoids, Plasmodium falciparum, Sesquiterpenes, Artemisinins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review