Cited by 159Malaria Research and ControlPhytochemical compounds biological activitiesSesquiterpenes and Asteraceae Studies

Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones

Elford, Barry C., Roberts, Margaret F., Phillipson, J.David, Wilson, Robert J.M.·1987·Transactions of the Royal Society of Tropical Medicine and Hygiene

Abstract

Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua, from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.

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Crossref · 10.1016/0035-9203(87)90161-1

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19 of 19 references verified0 citation errors · 0 not checkable

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Authors
Elford, B. C., Roberts, M. F., Phillipson, J. D., & Wilson, R. J. M.
Affiliations
University of London (GB)
Venue
Transactions of the Royal Society of Tropical Medicine and Hygiene
Published
1987-01
Volume
81
Issue
3
Pages
434-436
ISSN
0035-9203 (ISSN-L)
OpenAlex
W2121036679
Cited by
159
References
18
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 10
FWCI
4.37
Type
journal article
Language
en
Open access
closed
Locations
  • Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
Keywords
artemisinin, methoxylated flavones, casticin, artemetin, chloroquine resistance, Plasmodium falciparum, Artemisia annua, drug interactions, antimalarial activity
MeSH terms
Animals, Antimalarials, Clone Cells, Dose-Response Relationship, Drug, Drug Synergism, Flavonoids, Plasmodium falciparum, Sesquiterpenes, Artemisinins

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