Studies on Phenolic Steroids in Human Subjects. II. The Metabolic Fate and Hepato-Biliary-Enteric Circulation of C14-Estrone and C14-Estradiol in Women1

Sandberg, Avery A.; Slaunwhite, W. Roy

doi:10.1172/jci103524

Cited by 184Estrogen and related hormone effectsSteroid Chemistry and BiochemistryPharmacogenetics and Drug Metabolism

Studies on Phenolic Steroids in Human Subjects. II. The Metabolic Fate and Hepato-Biliary-Enteric Circulation of C14-Estrone and C14-Estradiol in Women1

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Sandberg, Avery A., Slaunwhite, W. Roy·1957·Journal of Clinical Investigation

DOI 10.1172/jci103524PMC PMC1072719

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METHODS AND MATERIALSOne to two /sc. of 16-C1'-estrone (B1) or 16-CM-estra- diol-17,B (E2) 2 (both 1Elc.per 370 pg.) were injected 2C4.-estrone and C"-estradiol were purchased from Charles E. Frosst & Co., Montreal, Canada.When the preparations were chromatographed in our laboratory, 1266

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Estrogens seem to undergo higher biliary excretion than other steroids, but also higher reabsorption leading to low fecal excretion.
“estrogens seem to undergo higher biliary excretion than other steroids, but also higher reabsorption leading to low fecal excretion [194,206].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [206]

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Authors: Sandberg, A. A., & Slaunwhite, W. R.
Affiliations: Roswell Park Comprehensive Cancer Center (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1957-08-01
Volume: 36
Issue: 8
Pages: 1266-1278
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci103524
PMC: PMC1072719
OpenAlex: W2145281171
Cited by: 184
References: 41
Citations by year: 2026: 6 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1
FWCI: 5.64
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: phenolic steroids, estrone, estradiol, radiolabeled steroids, metabolic fate, hepatic metabolism, biliary excretion, intestinal circulation, women, steroid metabolism
MeSH terms: Estradiol, Estrogens, Estrone, Female, Humans, Steroids, Gastrointestinal Tract, Lipid Metabolism

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Studies on Phenolic Steroids in Human Subjects. II. The Metabolic Fate and Hepato-Biliary-Enteric Circulation of C14-Estrone and C14-Estradiol in Women1

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