Age-Associated Changes in Superoxide Dismutase Activity, Thiobarbituric Acid Reactivity and Reduced Glutathione Level in the Brain and Liver in Senescence Accelerated Mice (SAM): A Comparison with DdY Mice
Abstract
The antioxidant defense alteration in young and old senescence accelerated mice (SAM) was studied by examining superoxide dismutase (SOD) activity, thiobarbituric acid (TBA) reactivity, and reduced glutathione (GSH) level in brain and liver tissues. The changes were compared with those in age-paired ddY mice, a strain exhibiting normal aging. SAM mice showed an age-dependent increase in SOD activity in liver, and an age-dependent increase in TBA reactivity in both the brain and the liver; they also showed an age-dependent decrease in the GSH level in the brain and the liver. When compared with ddY mice, SAM mice showed a higher SOD activity in the brain (at both 3 and 11 months old), a lower GSH level in the liver (at 3 months old), and a higher TBA reactivity in the liver (at 3 months old). These findings suggest that the mechanism of senescence acceleration in SAM mice is to some extent related to free radical damage.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous evidence reports an age-related decline in GSH levels in both the brain and the liver of SAM mice, along with other antioxidant molecules.
“These data are consistent with previous evidence reporting an age-related decline in GSH levels both in the brain and the liver of SAM mice, along with other antioxidant molecules [194].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [194]
Cites
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330 · see citing works
A fluorometric method for determination of oxidized and reduced glutathione in tissues
Hissin, P. J., & Hilf, R. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90326-2 · Cited by 4,106 · see citing works
AN ATTEMPT AT A RATIONAL CLASSIFICATION OF THEORIES OF AGEING
Медведев, Ж. А. (1990) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1990.tb01428.x · Cited by 515 · see citing works
Senescence‐Accelerated Mouse (SAM): A Novel Murine Model of Accelerated Senescence
Takeda, T., Hosokawa, M., & Higuchi, K. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb04460.x · Cited by 367 · see citing works
Cutler, R. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.373s · Cited by 280 · see citing works
LIPID PEROXIDATION AND FLUORESCENT MOLECULAR DAMAGE TO MEMBRANES
Tappel, A. L. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-701501-9.50008-8 · Cited by 265 · see citing works
Sawada, M., & Carlson, J. C. (1987) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(87)90057-1 · Cited by 238 · see citing works
Zhang, J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397155-5.00029-5 · Cited by 233 · see citing works
Hosokawa, M., Kasai, R., Higuchi, K., Takeshita, S., Shimizu, K., Hamamoto, H., Honma, A., Irino, M., Toda, K., Matsumura, A., et al. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90168-4 · Cited by 222 · see citing works
Gutteridge, J. M. C. (1982) · International Journal of Biochemistry · doi:10.1016/0020-711x(82)90050-7 · Cited by 192 · see citing works
Age‐Related Differences in Synaptosomal Peroxidative Damage and Membrane Properties
Viani, P., Cervato, G., Fiorilli, A., & Cestaro, B. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02589.x · Cited by 176 · see citing works
Munday, R., & Winterbourn, C. C. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90641-2 · Cited by 141 · see citing works
Superoxide Dismutase in the Rat and Mouse as a Function of Age and Longevity
Kellogg, E. W., & Fridovich, I. (1976) · Journal of Gerontology · doi:10.1093/geronj/31.4.405 · Cited by 125 · see citing works
Anti-oxidant defences and peroxidation in liver and brain of aged rats
Barja, G., Pérez‐Campo, R., & Torres, M. L. (1990) · Biochemical Journal · doi:10.1042/bj2720247 · Cited by 124 · see citing works
Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM)
Takeshita, S., Hosokawa, M., Irino, M., Higuchi, K., Shimizu, K., Yasuhira, K., & Takeda, T. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90070-7 · Cited by 115 · see citing works
Higuchi, K., Matsumura, A., Honma, A., et al. (1983) · PubMed · Cited by 110 · see citing works
GEREMIA, E., BARATTA, D., Zafarana, S., et al. (1990) · Neurochemical Research · doi:10.1007/bf00973653 · Cited by 92 · see citing works
Superoxide Dismutase Activities in Aging Rat Brain
Vanella, A., GEREMIA, E., D’Urso, G., Tiriolo, P., Silvestro, I. D., Grimaldi, R., & Pinturo, R. (2009) · Gerontology · doi:10.1159/000212519 · Cited by 77 · see citing works
Hiramatsu, M., Kohno, M., Edamatsu, R., Mitsuta, K., & Mori, A. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09375.x · Cited by 70 · see citing works
Self-citationHosokawa, M., Takeshita, S., Higuchi, K., et al. (1984) · Experimental Eye Research · doi:10.1016/0014-4835(84)90095-2 · Cited by 69 · see citing works
Age-associated changes in antioxidants and antioxidative enzymes in rats
De, A. K., & Darad, R. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90078-e · Cited by 54 · see citing works
Superoxide dismutase activity in developing rat brain
Mavelli, I., Mondovı̀, B., Federico, R., & Rotilio, G. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb12472.x · Cited by 39 · see citing works
Higuchi, K., Matsumura, A., Hashimoto, K., et al. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.158.5.1600 · Cited by 39 · see citing works
Takeshita, S., Higuchi, K., Hosokawa, M., et al. (1985) · PubMed · Cited by 14 · see citing works
Hiramatsu, M., Edamatsu, R., & Mori, A. (1992) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7460-1_21 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Melatonin Reduces Oxidative Damage of Neural Lipids and Proteins in Senescence-Accelerated Mouse
Okatani, Y., Wakatsuki, A., Reiter, R. J., & Miyahara, Y. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00005-2 · Cited by 112 · see citing works
Kawamata, T. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00063-0 · Cited by 72 · see citing works
HWANG, J.-H., LEE, I.-T., JENG, K.-C., WANG, M.-F., HOU, R. C.-W., WU, S.-M., & CHAN, Y.-C. (2011) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.57.186 · Cited by 71 · see citing works
George, S. K., Jiao, Y., Bishop, C. E., & Lu, B. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00686.x · Cited by 66 · see citing works
- Authors
- Liu, J., & Mori, A.
- Affiliations
- Okayama University (JP)
- Corresponding author
- Mori, Akitane
- ORCID
- Liu, Jiankang
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 1993-10
- Volume
- 71
- Issue
- 1-2
- Pages
- 23-30
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2029449819
- Cited by
- 104
- References
- 27
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- senescence-accelerated mice, ddY mice, superoxide dismutase, reduced glutathione, antioxidant defense, oxidative damage, oxidative stress, brain aging, liver aging, age-related changes
- MeSH terms
- Aging, Animals, Brain, Glutathione, Liver, Mice, Inbred Strains, Organ Specificity, Species Specificity, Superoxide Dismutase, Thiobarbiturates, Time Factors, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review