Cited by 104Genetics, Aging, and Longevity in Model OrganismsAntioxidant Activity and Oxidative StressAntioxidants, Aging, Portulaca oleracea

Age-Associated Changes in Superoxide Dismutase Activity, Thiobarbituric Acid Reactivity and Reduced Glutathione Level in the Brain and Liver in Senescence Accelerated Mice (SAM): A Comparison with DdY Mice

Liu, Jiankang, Mori, Akitane·1993·Mechanisms of Ageing and Development

Abstract

The antioxidant defense alteration in young and old senescence accelerated mice (SAM) was studied by examining superoxide dismutase (SOD) activity, thiobarbituric acid (TBA) reactivity, and reduced glutathione (GSH) level in brain and liver tissues. The changes were compared with those in age-paired ddY mice, a strain exhibiting normal aging. SAM mice showed an age-dependent increase in SOD activity in liver, and an age-dependent increase in TBA reactivity in both the brain and the liver; they also showed an age-dependent decrease in the GSH level in the brain and the liver. When compared with ddY mice, SAM mice showed a higher SOD activity in the brain (at both 3 and 11 months old), a lower GSH level in the liver (at 3 months old), and a higher TBA reactivity in the liver (at 3 months old). These findings suggest that the mechanism of senescence acceleration in SAM mice is to some extent related to free radical damage.

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Crossref · 10.1016/0047-6374(93)90032-m

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  • Previous evidence reports an age-related decline in GSH levels in both the brain and the liver of SAM mice, along with other antioxidant molecules.

    “These data are consistent with previous evidence reporting an age-related decline in GSH levels both in the brain and the liver of SAM mice, along with other antioxidant molecules [194].”

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Authors
Liu, J., & Mori, A.
Affiliations
Okayama University (JP)
Corresponding author
Mori, Akitane
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
1993-10
Volume
71
Issue
1-2
Pages
23-30
ISSN
0047-6374 (ISSN-L)
OpenAlex
W2029449819
Cited by
104
References
27
Citations by year
2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 1
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords
senescence-accelerated mice, ddY mice, superoxide dismutase, reduced glutathione, antioxidant defense, oxidative damage, oxidative stress, brain aging, liver aging, age-related changes
MeSH terms
Aging, Animals, Brain, Glutathione, Liver, Mice, Inbred Strains, Organ Specificity, Species Specificity, Superoxide Dismutase, Thiobarbiturates, Time Factors, Mice

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