Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory

Robbins pathologic basis of disease

Cotran, R. S., Kumar, V., & Collins, T. (1989) · Medical Entomology and Zoology · Cited by 1,944 · see citing works

A new murine model of accelerated senescence

Takeda, T., HOSOKAWA, M., TAKESHITA, S., Irino, M., Higuchi, K., Matsushita, T., Tomita, Y., Yasuhira, K., Hamamoto, H., & Shimizu, K. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90084-1 · Cited by 871 · see citing works

Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)

Miyamoto, M., Kiyota, Y., Yamazaki, N., Nagaoka, A., Matsuo, T., Nagawa, Y., & Takeda, T. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90112-5 · Cited by 375 · see citing works

Senescence‐Accelerated Mouse (SAM): A Novel Murine Model of Accelerated Senescence

Takeda, T., Hosokawa, M., & Higuchi, K. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb04460.x · Cited by 367 · see citing works

Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide

Hess, D. T., Patterson, S. I., Smith, D. S., & Skene, J. H. P. (1993) · Nature · doi:10.1038/366562a0 · Cited by 327 · see citing works

Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory

Yagi, H., Katoh, S., Akiguchi, I., & Takeda, T. (1988) · Brain Research · doi:10.1016/0006-8993(88)90671-3 · Cited by 241 · see citing works

Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis.

Matsushita, M., Tsuboyama, T., Kasai, R., Okumura, H., Yamamuro, T., Higuchi, K., Higuchi, K., Kohno, A., Yonezu, T., & Utani, A. (1986) · PubMed Central · Cited by 233 · see citing works

Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM)

Hosokawa, M., Kasai, R., Higuchi, K., Takeshita, S., Shimizu, K., Hamamoto, H., Honma, A., Irino, M., Toda, K., Matsumura, A., et al. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90168-4 · Cited by 222 · see citing works

Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor

Flood, J. F., Morley, J. E., & Lanthorn, T. H. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90709-d · Cited by 153 · see citing works

Spontaneous Spongy Degeneration of the Brain Stem in SAM-P/8 Mice, a Newly Developed Memory-Deficient Strain

Yagi, H., Irino, M., Matsushita, T., et al. (1989) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198909000-00008 · Cited by 122 · see citing works

Early Onset of Age-Related Impairment of Aversive and Appetitive Learning in the SAM-P/8 Mouse

Flood, J. F., & Morley, J. E. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.2.b52 · Cited by 111 · see citing works

The SAM Model of Senescence

Takeda, T. (1994) · Medical Entomology and Zoology · Cited by 111 · see citing works

Systemic senile amyloid in senescence-accelerated mice. A unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method.

Higuchi, K., Matsumura, A., Honma, A., et al. (1983) · PubMed · Cited by 110 · see citing works

Age-Associated Changes in Superoxide Dismutase Activity, Thiobarbituric Acid Reactivity and Reduced Glutathione Level in the Brain and Liver in Senescence Accelerated Mice (SAM): A Comparison with DdY Mice

Liu, J., & Mori, A. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90032-m · Cited by 104 · see citing works

Inbred SAM-P/10 as a Mouse Model of Spontaneous, Inherited Brain Atrophy

Shimada, A., Ohta, A., Akiguchi, I., & Takeda, T. (1992) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199207000-00006 · Cited by 103 · see citing works

Beta/A4 proteinlike immunoreactive granular structures in the brain of senescence-accelerated mouse.

Takemura, M., Nakamura, S., Akiguchi, I., Ueno, M., Oka, N., Ishikawa, S., Shimada, A., Kimura, J., & Takeda, T. (1993) · PubMed Central · Cited by 94 · see citing works

Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM)

Akiyama, H., Kameyama, M., Akiguchi, I., Sugiyama, H., Kawamata, T., Fukuyama, H., Kimura, H., Matsushita, M., & Takeda, T. (1986) · Acta Neuropathologica · doi:10.1007/bf00685973 · Cited by 84 · see citing works

Age-related deposition of glia-associated fibrillar material in brains of c57BL/6 mice

Jucker, M., Walker, L. C., Schwarb, P., Hengemihle, J. M., Kuo, H.-K., Snow, A. D., Bamert, F., & Ingram, D. K. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90269-0 · Cited by 76 · see citing works

Biochemical changes related to aging in the senescence-accelerated mouse

Nomura, Y., Wang, B.-X., Qi, S.-B., Namba, T., & Kaneko, S. (1989) · Experimental Gerontology · doi:10.1016/0531-5565(89)90034-x · Cited by 76 · see citing works

Immune responses in newly developed short-lived SAM mice. I. Age-associated early decline in immune activities of cultured spleen cells.

Hosokawa, T., Hosono, M., Higuchi, K., et al. (1987) · PubMed · Cited by 69 · see citing works

Age-related changes in transmitter glutamate and NMDA receptor/channels in the brain of senescence-accelerated mouse

Kitamura, Y., Zhao, X., Ohnuki, T., Takei, M., & Nomura, Y. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90396-o · Cited by 69 · see citing works

Age-related changes in the temporomandibular joint of the senescence accelerated mouse. SAM-P/3 as a new murine model of degenerative joint disease.

Chen, W. H., Hosokawa, M., Tsuboyama, T., et al. (1989) · PubMed · Cited by 68 · see citing works

Age-related deterioration in conditional avoidance task in the SAM-P/10 mouse, an animal model of spontaneous brain atrophy

Shimada, A., Ohta, A., Akiguchi, I., et al. (1993) · Brain Research · doi:10.1016/0006-8993(93)91467-7 · Cited by 64 · see citing works

Age-related changes in the pharmacological improvement of retention in senescence accelerated mouse (SAM)

Flood, J. F., Morley, J. E., & Reginna, M. L. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90092-p · Cited by 64 · see citing works

Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases

(1990) · Advances in behavioral biology · doi:10.1007/978-1-4684-5844-2 · Cited by 63 · see citing works

Localization of atrophy-prone areas in the aging mouse brain: Comparison between the brain atrophy model SAM-P/10 and the normal control SAM-R/1

Shimada, A., Hosokawa, M., Ohta, A., Akiguchi, I., & Takeda, T. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90290-9 · Cited by 60 · see citing works

Age‐related changes in uptake and release on l ‐[3H]noradrenaline in brain slices of senescence accelerated mouse

Zhao, X., & Nomura, Y. (1990) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(90)90032-w · Cited by 50 · see citing works

Ligand-binding characteristics of [3H]QNB, [3H]prazosin, [3H]rauwolscine, [3H]TCP and [3H]nitrendipine to cerebral cortical and hippocampal membranes of senescence accelerated mouse

Kitamura, Y., Zhao, X., Ohnuki, T., & Nomura, Y. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90186-9 · Cited by 45 · see citing works

Age‐related changes in NMDA‐induced [3H]acetylcholine release from brain slices of senescene‐accelerated mouse

Zhao, X., Kitamura, Y., & Nomura, Y. (1992) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(92)90040-7 · Cited by 44 · see citing works

Cataract in Senescence Accelerated Mouse (SAM) 2. Development of a new strain of mouse with late-appearing cataract

Hosokawa, M., Ashida, Y., Tsuboyama, T., et al. (1988) · Experimental Eye Research · doi:10.1016/0014-4835(88)90100-5 · Cited by 42 · see citing works

Increased Expression of Cathepsins E and D in Reactive Microglial Cells Associated with Spongiform Degeneration in the Brain Stem of Senescence-Accelerated Mouse

Amano, T., Nakanishi, H., Masuichiro, O. K. A., et al. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1094 · Cited by 41 · see citing works

Age-related changes in barrier function in mouse brain I. Accelerated age-related increase of brain transfer of serum albumin in accelerated senescence prone SAM-P/8 mice with deficits in learning and memory

Ueno, M., Akiguchi, I., Yagi, H., Naiki, H., Fujibayashi, Y., Kimura, J., & Takeda, T. (1993) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(93)90035-g · Cited by 39 · see citing works

Effect of aging on NADPH-diaphorase neurons in laterodorsal tegmental nucleus and striatum of mice

Kawamata, T., Nakamura, S., Akiguchi, I., Kimura, J., Kameyama, M., Kimura, H., & Takeda, T. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90544-a · Cited by 37 · see citing works

Early changes in glucose metabolism in the cerebrum of senescence accelerated mouse: involvement of glucose transporter

Sato, E., Inoue, A., Kurokáwa, T., & Ishibashi, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91226-2 · Cited by 29 · see citing works

Expression of neurotrophin genes in the brain of senescence-accelerated mouse (SAM) during postnatal development

Kaisho, Y., Miyamoto, M., Shiho, O., Onoue, H., Kitamura, Y., & Nomura, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91408-7 · Cited by 26 · see citing works

Differential Aging Pattern of Cerebral Accumulation of Radiolabeled Glucose and Amino Acid in the Senescence Accelerated Mouse (SAM), a New Model for the Study of Memory Impairment.

Fujibayashi, Y., Waki, A., Wada, K., et al. (1994) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.17.102 · Cited by 23 · see citing works

Accumulation of blood-borne horseradish peroxidase in medial portions of the mouse hippocampus

Ueno, M., Akiguchi, I., Hosokawa, M., et al. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb02748.x · Cited by 19 · see citing works

[Loss of dendritic spines in hippocampal CA1 pyramidal cells in senescence accelerated mouse (SAM)--a quantitative Golgi study].

Sugiyama, H., Akiyama, H., Akiguchi, I., Kameyama, M., & Takeda, T. (1987) · PubMed · Cited by 19 · see citing works

Monoamine oxidase-B-positive granular structures in the hippocampus of aged senescence-accelerated mouse (SAMP8)

Nakamura, S., Akiguchi, I., Seriu, N., et al. (1995) · Acta Neuropathologica · doi:10.1007/bf00318576 · Cited by 18 · see citing works

The persistence of high uptake of serum albumin in the olfactory bulbs of mice throughout their adult lives

Ueno, M., Akiguchi, I., Naiki, H., et al. (1991) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(91)90062-u · Cited by 18 · see citing works

Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice

Ohnishi, K., Tomimoto, H., Akiguchi, I., Seriu, N., Kawamata, T., Nakamura, S., Kimura, J., Nishio, T., Higuchi, K., & Hosokawa, M. (1995) · Acta Neuropathologica · doi:10.1007/bf00294454 · Cited by 18 · see citing works

Age-related changes in levels of the β-subunit of nerve growth factor in selected regions of the brain: comparison between senescence-accelerated (SAM-P8) and senescence-resistant (SAM-R1) mice

Katoh‐Semba, R., & Kato, K. (1994) · Neuroscience Research · doi:10.1016/0168-0102(94)90094-9 · Cited by 15 · see citing works

Age-related alteration of brain gangliosides in senescence-accelerated mouse (SAM)-P/8 9

Ohsawa, T., & Shumiya, S. (1991) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(91)90137-o · Cited by 13 · see citing works

Brain stem reticular formation neuronal correlates of stimulus significance and behavior during discriminative avoidance conditioning in rabbits.

Gabriel, M., & al., E. (1986) · Behavioral Neuroscience · doi:10.1037//0735-7044.100.2.171 · Cited by 11 · see citing works

Treatment of Primary Intracranial Germinomas

Sato, Y., Matsuoka, Y., & Nakamura, T. (1987) · Neurologia medico-chirurgica · doi:10.2176/nmc.27.841 · Cited by 5 · see citing works

Effect of Aging on NADPH-Diaphorase Neurons in Laterodorsal Tegmental Nucleus and Striatum of Senescence Accelerated Mouse (SAM)

Kawamata, T., Nakamura, S., Akiguchi, I., et al. (1990) · Advances in behavioral biology · doi:10.1007/978-1-4684-5844-2_143 · Cited by 4 · see citing works

Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain

Akiguchi, I., Kawamata, T., Yagi, H., et al. (1990) · Advances in behavioral biology · doi:10.1007/978-1-4684-5844-2_141 · Cited by 2 · see citing works

Tau protein kinases: Involvement in Alzheimer's disease

Martin, L., Latypova, X., Wilson, C. M., Magnaudeix, A., Perrin, M.-L., Yardin, C., & Terro, F. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.06.003 · Cited by 631 · see citing works

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)

Ramkumar, H. L., Zhang, J., & Chan, C.-C. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.02.002 · Cited by 163 · see citing works

Mechanisms of aging in senescence-accelerated mice

Carter, T. A., Greenhall, J. A., Yoshida, S., Fuchs, S., Helton, R., Swaroop, A., Lockhart, D. J., & Barlow, C. (2005) · Genome Biology · doi:10.1186/gb-2005-6-6-r48 · Cited by 64 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Initiation, Progression, and Genetic Manipulation of Leaf Senescence

Ali, A. A., Gao, X., & Guo, Y. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7672-0_2 · Cited by 27 · see citing works

Leaf senescence in rice plants: cloning and characterization of senescence up‐regulated genes

Lee, R., Wang, C., Huang, L., et al. (2001) · Journal of Experimental Botany · doi:10.1093/jexbot/52.358.1117 · Cited by 195 · see citing works

Brassinosteroids and Senescence

Çağ, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-6058-9_6 · Cited by 3 · see citing works

Gene expression during leaf senescence

Smart, C. M. (1994) · New Phytologist · doi:10.1111/j.1469-8137.1994.tb04243.x · Cited by 708 · see citing works