PGE2 and PGF2α release by human peritoneal macrophages in endometriosis

Karck, Ulrich; Reister, Frank; Schdfer, Wolfgang; Zahradnik, Hans-Peter; Breckwoldt, Meinert

doi:10.1016/0090-6980(95)00159-x

Cited by 75Endometriosis Research and TreatmentInflammatory mediators and NSAID effectsEctopic Pregnancy Diagnosis and Management

PGE2 and PGF2α release by human peritoneal macrophages in endometriosis

Karck, Ulrich, Reister, Frank, Schdfer, Wolfgang, Zahradnik, Hans-Peter, Breckwoldt, Meinert·1996·Prostaglandins

DOI 10.1016/0090-6980(95)00159-x

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Abstract

Objective To test for differences in the amount and activity of peritoneal macrophages present in the peritoneal fluid of women with, and without endometriosis using prostaglandin release by macrophages in culture as a marker. Patients Women of reproductive age undergoing laparoscopy for infertility or chronic pelvic pain with postoperative diagnosis of endometriosis and women undergoing laparoscopy for sterilization. Methods Peritoneal fluid was aspirated during laparascopy, volume was recorded, macrophages were isolated via a Ficoll Paque gradient and kept in primary culture. PGE2 and PGF2 alpha release of the cells were measured before and after stimulation with zymosan. Results Women with endometriosis had significantly more peritoneal macrophages than controls. Peritoneal macrophages of women with endometriosis released significantly more PGE2 than those of the control group: 8.4 +/- 2.0 versus 1.4 +/- 0.4 ng/ml/10(6) cells (mean +/- SEM, p = 0.0005) and PGF2 alpha: 10 +/- 4.3 (endometriosis) versus 1.8 +/- 0.4 (control) ng/ml/10(6) cells (mean +/- SEM, p = 0.045). Conclusion There is a significant increase in the amount of prostaglandins released by peritoneal macrophages from women with endometriosis. These prostaglandins might alter uterine and tubal contractility, thereby affecting fertility.

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TNFα and IL-1β have the capacity to stimulate expression of COX-2 and increase secretion of prostaglandin E2 by endometriotic cells and peritoneal macrophages.
“which have the capacity to stimulate expression of the prostaglandin synthesis enzyme COX-2 and increase secretion of prostaglandin E2 (PGE2) by endometriotic cells and peritoneal macrophages [72,73].”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [73]

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Authors: Karck, U., Reister, F., Schdfer, W., Zahradnik, H.-P., & Breckwoldt, M.
Affiliations: University Medical Center Freiburg (DE)
Corresponding author: Karck, Ulrich
ORCID: Reister, Frank
Venue: Prostaglandins
Publisher: Elsevier BV
Published: 1996-01
Volume: 51
Issue: 1
Pages: 49-60
ISSN: 0090-6980 (ISSN-L)
DOI: 10.1016/0090-6980(95)00159-x
OpenAlex: W1979401373
Cited by: 75
References: 29
Citations by year: 2025: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 3
FWCI: 2.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Prostaglandins (publishedVersion)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords: endometriosis, peritoneal macrophages, prostaglandin E2, prostaglandin F2alpha, prostaglandin release, peritoneal fluid, zymosan stimulation, infertility, chronic pelvic pain, uterine contractility
MeSH terms: Adult, Ascitic Fluid, Endometriosis, Extracellular Space, Female, Humans, Infertility, Thromboxane B2, 6-Ketoprostaglandin F1 alpha, Dinoprostone, Dinoprost, Macrophages, Peritoneal

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PGE2 and PGF2α release by human peritoneal macrophages in endometriosis

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