Aberrant Expression of Apoptosis-Related Molecules in Endometriosis: A Possible Mechanism Underlying the Pathogenesis of Endometriosis
Abstract
Endometriosis, a disease affecting 3% to 10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue under the influence of estrogen. It is also becoming recognized as a condition in which ectopic endometrial cells exhibit abnormal proliferative and apoptotic regulation in response to appropriate stimuli. Apoptosis plays a critical role in maintaining tissue homeostasis and represents a normal function to eliminate excess or dysfunctional cells. Accumulated evidence suggests that, in healthy women, endometrial cells expelled during menstruation do not survive in ectopic locations because of programmed cell death, while decreased apoptosis may lead to the ectopic survival and implantation of these cells, resulting in the development of endometriosis. Both the inability of endometrial cells to transmit a "death" signal and the ability of endometrial cells to avoid cell death have been associated with increased expression of antiapoptotic factors and decreased expression of preapoptotic factors. Further investigations may elucidate the role of apoptosis-associated molecules in the pathogenesis of endometriosis. Medical treatment with apoptosis-inducing agents may be novel and promising therapeutic strategy for endometriosis.
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Decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis.
“It is thought that the decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis.109,110”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [110]
Women with endometriosis are reported to have reduced endometrial apoptosis with increased expression of antiapoptotic and decreased expression of proapoptotic factors.
“Women with endometriosis are reported to have reduced endometrial apoptosis with increased expression of antiapoptotic and decreased expression of proapoptotic factors.”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [110]
Endometrial BCL-2 expression may be stimulated by estrogen and downregulated by progesterone.
“Endometrial BCL-2 expression may be stimulated by estrogen and downregulated by progesterone.110”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [110]
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Rogers, P. A. W., D’Hooghe, T. M., Fazleabas, A., Giudice, L. C., Montgomery, G. W., Petraglia, F., & Taylor, R. N. (2013) · Reproductive Sciences · doi:10.1177/1933719113477495 · Cited by 154 · see citing works
Endometriosis and adenomyosis: Similarities and differences
Donnez, J., Stratopoulou, C. A., & Dolmans, M.-M. (2024) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2023.102432 · Cited by 57 · see citing works
- Authors
- Nasu, K., Nishida, M., Kawano, Y., Tsuno, A., Abe, W., Yuge, A., Takai, N., & Narahara, H.
- Affiliations
- Oita University (JP)
- Corresponding author
- Nasu, Kaei
- Venue
- Reproductive Sciences
- Published
- 2011-03
- Volume
- 18
- Issue
- 3
- Pages
- 206-218
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- OpenAlex
- W2126371827
- Cited by
- 73
- References
- 166
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, apoptosis, endometrial cells, anti-apoptotic factors, endometriosis pathogenesis, apoptosis inducers, estrogen
- MeSH terms
- Endometriosis, Endometrium, Female, Gene Expression Regulation, Humans, Apoptosis, Protein Serine-Threonine Kinases, Genes, cdc, Genes, bcl-2
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