Cited by 73Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementReproductive System and Pregnancy

Aberrant Expression of Apoptosis-Related Molecules in Endometriosis: A Possible Mechanism Underlying the Pathogenesis of Endometriosis

Nasu, Kaei, Nishida, Masakazu, Kawano, Yukie, Tsuno, Akitoshi, Abe, Wakana, Yuge, Akitoshi, Takai, Noriyuki, Narahara, Hisashi·2011·Reproductive Sciences

Abstract

Endometriosis, a disease affecting 3% to 10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue under the influence of estrogen. It is also becoming recognized as a condition in which ectopic endometrial cells exhibit abnormal proliferative and apoptotic regulation in response to appropriate stimuli. Apoptosis plays a critical role in maintaining tissue homeostasis and represents a normal function to eliminate excess or dysfunctional cells. Accumulated evidence suggests that, in healthy women, endometrial cells expelled during menstruation do not survive in ectopic locations because of programmed cell death, while decreased apoptosis may lead to the ectopic survival and implantation of these cells, resulting in the development of endometriosis. Both the inability of endometrial cells to transmit a "death" signal and the ability of endometrial cells to avoid cell death have been associated with increased expression of antiapoptotic factors and decreased expression of preapoptotic factors. Further investigations may elucidate the role of apoptosis-associated molecules in the pathogenesis of endometriosis. Medical treatment with apoptosis-inducing agents may be novel and promising therapeutic strategy for endometriosis.

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Crossref · 10.1177/1933719110392059

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166 of 166 references verified0 citation errors · 0 not checkable

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Authors
Nasu, K., Nishida, M., Kawano, Y., Tsuno, A., Abe, W., Yuge, A., Takai, N., & Narahara, H.
Affiliations
Oita University (JP)
Corresponding author
Nasu, Kaei
Venue
Reproductive Sciences
Published
2011-03
Volume
18
Issue
3
Pages
206-218
ISSN
  • 1933-7191 (ISSN-L)
  • 1933-7205
OpenAlex
W2126371827
Cited by
73
References
166
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 3
FWCI
0.59
Type
journal article
Language
en
Open access
closed
Locations
  • Reproductive Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
endometriosis, apoptosis, endometrial cells, anti-apoptotic factors, endometriosis pathogenesis, apoptosis inducers, estrogen
MeSH terms
Endometriosis, Endometrium, Female, Gene Expression Regulation, Humans, Apoptosis, Protein Serine-Threonine Kinases, Genes, cdc, Genes, bcl-2

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