Suppressive effects of intraperitoneal and intraventricular injections of nicotine on muricide and shock-induced attack on conspecifics
Abstract
Rats were used to investigate the effect of nicotine on mouse-killing and foot shock-induced attack on conspecifics. It was found that intraperitoneal injections of nicotine (100-1000 micrograms/kg) suppressed mouse-killing in a dose dependent manner. The suppression of mouse-killing by nicotine was not blocked by hexamethonium (30 mg/kg), a peripheral nicotinic receptor blocking agent. Mecamylamine (30 mg/kg), a nicotinic blocking agent with central effects, did reduce the inhibition of attack produced by nicotine. Both intraperitoneal and intraventricular injections of nicotine suppressed shock-induced attack on conspecifics. Shock-elicited flinch, vocalization, and escape were not influenced by nicotine injections. These findings give further support to the view that muscarinic and nicotinic compounds produce antagonistic effects on certain types of attack behavior.
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Effects of nicotine in the muricide study did not stem from a general sedating effect, were not affected by peripheral nAChR blockade with hexamethonium, and were blocked by mecamylamine.
“effects of nicotine in the muricide study did not stem from a general sedating effect, were not affected by peripheral nAChR blockade with hexamethonium, and were blocked by mecamylamine (Waldbillig, 1980)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Waldbillig, 1980
Nicotine reduces aggression in rats in many different paradigms, including shock-induced fighting, frustrative non-reward, and a muricide model.
“Nicotine reduces aggression in rats in many different paradigms, including shock-induced fighting (Driscoll and Baettig, 1981; Rodgers, 1979; Waldbillig, 1980), frustrative non-reward (reaction to the inability to obtain rewards following repeated efforts; (Schechter, 1974), and a muricide model (Waldbillig, 1980).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Waldbillig, 1980
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Picciotto, M. R., Lewis, A. S., van Schalkwyk, G. I., & Mineur, Y. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.028 · Cited by 157 · see citing works
Effects of nicotine on target biting and resident-intruder attack
Johnson, S. K., Carlson, K. M., Lee, J., Burr, L. E., & Wagner, G. C. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00289-3 · Cited by 14 · see citing works
- Authors
- Waldbillig, R. J.
- Affiliations
- University of Florida (US)
- Corresponding author
- Waldbillig, Robert J.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1980-04
- Volume
- 12
- Issue
- 4
- Pages
- 619-623
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1989836735
- Cited by
- 24
- References
- 14
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 1 · 2015: 3
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, mouse-killing behavior, attack behavior, intraventricular injection, intraperitoneal injection, nicotinic acetylcholine receptors, muscarinic receptors, mecamylamine, hexamethonium, conspecific aggression, rats
- MeSH terms
- Aggression, Animals, Electroshock, Hexamethonium Compounds, Humans, Injections, Intraperitoneal, Injections, Intraventricular, Male, Mecamylamine, Nicotine, Vocalization, Animal, Mice, Rats
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