Effects of nicotine on target biting and resident-intruder attack
Abstract
The effects of acute administration of nicotine on target biting (defensive) and resident-intruder (offensive) attack of male mice were assessed. In the target biting procedure confined mice received tail shock on a fixed time, 2-min schedule. Under baseline conditions, biting attack directed toward an inanimate target occurred at three distinct rates. A high target biting rate (13.5 +/- 3.8 bites/15 sec) followed shock delivery, an intermediate biting rate (9.6 +/- 4.1 bites/15 sec) occurred during the inter-shock interval, and a low biting rate (1.0 +/- 0.5 bites/15 sec) occurred during a tone stimulus which signalled the impending shock. Nicotine (administered IP, 15 min presession) reduced post-shock and inter-shock interval target biting in a dose-dependent manner (ED50 values estimated at 0.13 and 0.14 mg/kg, respectively) but exerted more variable effects on target biting during the tone. In the resident-intruder paradigm the same mice were exposed to an intruder introduced into its home cage for a 10-min test session. Under baseline conditions, residents directed 20 +/- 3.2 biting attacks toward the intruder during the session with an average latency of 89 +/- 40 sec to the first attack. Nicotine caused a dose-dependent decrease in this attack behavior (ED50 values estimated to be 0.48 and 0.49 mg/kg, respectively). These observations are interpreted to indicate that nicotine has an increased potency at reducing "defensive" aggression.
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A more recent study assessing both target-biting and standard resident-intruder tests in mice found a dose-dependent reduction in aggression by nicotine.
“a more recent study assessing both target-biting and standard resident-intruder tests in mice, which found a dose-dependent reduction in aggression by nicotine in mice (Johnson et al., 2003)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Johnson et al., 2003
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Picciotto, M. R., Lewis, A. S., van Schalkwyk, G. I., & Mineur, Y. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.028 · Cited by 157 · see citing works
- Authors
- Johnson, S. K., Carlson, K. M., Lee, J., Burr, L. E., & Wagner, G. C.
- Affiliations
- University of North Carolina at Charlotte (US)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Wagner, George C.
- ORCID
- Wagner, George C.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 73
- Issue
- 3
- Pages
- 311-317
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2026920992
- Cited by
- 14
- References
- 15
- Citations by year
- 2019: 1 · 2018: 1 · 2017: 1 · 2015: 6 · 2014: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21ns043981-03)
- National Institute of Neurological Disorders and Stroke (NS 43981)
- National Institute of Environmental Health Sciences (ES 11256, ES-05022., P01ES011256, P30ES005022)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, defensive aggression, offensive aggression, tail shock, dose-response relationship
- MeSH terms
- Aggression, Animals, Bites and Stings, Dose-Response Relationship, Drug, Electroshock, Injections, Intraperitoneal, Male, Nicotine, Stress, Physiological, Mice
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